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Laura K. Mackay on Muck Rack

Laura K. Mackay

As seen in: Nature, Wiley Online Library, BMJ Open, Science Magazine, Pursuit, Cell Reports, Cell Press, Gay Times, techedge, SecEd and
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Articles

Tumor-resident T cells and dendritic cells form an in situ archetype during immunotherapy response in melanoma

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By Andrea Di Pietro, Lewis Au, Niko Thio, Angela Pizzolla, Thu Nguyen, Thu Nguyễn, Sean MacDonald, Hugh Chalmers, Ruiqing Zhu, Marina Bacac, Petra C. Schwalie, Mitchell Levesque, Karen L Winch, Joanna Chan, George Yeung, Lavinia Spain, Aparna Rao, Shahneen Sandhu, David E Gyorki, Grant McArthur Verified, Laura K. Mackay, Paul Neeson, Patrick Crock, Alessia Airaghi, Tristan Molden-Hauer, Ramona Schlenker, Sonia Mailer, Kristy Barnes-Cullen
| Nature Verified
Abstract Tumor-resident (TR) T cells, known as tissue-resident memory (TRM) T cells in mice, play a central role in melanoma immunosurveillance, yet their contribution to immune checkpoint inhibitor (ICI) therapy has not been comprehensively explored. We performed spatial and single-cell profiling on 32 metastatic melanoma lymph node samples, from treatment-naïve, ICI-resistant and ICI-responsive patients. Here we show that tumor areas in ICI-responders were enriched for both CD8+ and CD4+ TR.
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Spatial organization of tissue-resident memory T cells

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By Thomas N. Burn, Laura K. Mackay
| Cell Press Verified
Keywords tissue immunity T cell memory Introduction Immunological memory enables a faster and more robust immune response upon pathogen re-encounter. Memory of past threats is critical for survival, and all life forms have evolved strategies to retain it, from CRISPR-Cas systems in prokaryotes to adaptive immunity in jawed vertebrates.1,2,3 Two features define immunological memory: (1) specificity for an antigen that is no longer present and (2) rapid recall responses.
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Flt3L-mediated tumor cDC1 expansion enhances immunotherapy by priming stem-like CD8+ T cells in lymph nodes - Nature Immunology

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By Junyun Lai, Emily Derrick, Laura Carstensen, Christina Scheffler, Kevin Sek, Joelle S. Kim, Kah Min Yap, Isabelle Munoz, Dat Nguyen, Kirsten L. Todd, Maximilien Evrard, Jonathan Chee, Laura K. Mackay, Ian Parish, Anthony Bosco, Jason Waithman, Paul A. Beavis
| Nature Verified
Abstract Immune checkpoint blockade (ICB) evokes antitumor immunity through the reinvigoration of T cell responses. T cell differentiation status controls response, with less differentiated cells having an enhanced capacity to proliferate after ICB. Given that conventional type 1 dendritic cells (cDC1) maintain precursor exhausted T cells (TPEX), we hypothesized that expansion of cDC1s with Flt3L could enhance responses to ICB.
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