Sean McKinney

The patient had very mature cataracts with phacodonesis secondary to pseudoexfoliation syndrome. The dense cataracts had reduced her vision to counting fingers in one eye and hand motions in the other, causing her to be dependent on family for daily functions. A retinal specialist referred her to an anterior segment surgeon in a multispecialty tertiary care setting to assure appropriate retinal backup for this complex case.

Kathryn A. Colby, MD, PhD, reflects on the mid-1990s, when patients with a failing corneal endothelium had to wait for the onset of very poor vision before qualifying for penetrating keratoplasty, the only available treatment. “Fast forward 30 years, and we’re now talking about the potential use of medical therapy—without a wait for recovery from a procedure—for these same patients,” says Dr. Colby, Elizabeth J.

Keywords planarian niche stem cell regeneration Slide-seqV2 RNA-FACS-seq microenvironments spatial transcriptomics intestine CLEM Research topic(s) CP: Stem cell research Introduction Stem cells are defined by their ability to self-renew and differentiate into other cell types.