Shany Dror

Abstract Conformational biasing (CB) is a rapid and streamlined computational method that uses contrastive scoring by inverse folding models to predict protein variants biased toward desired conformational states. We successfully validated CB across seven diverse datasets, identifying variants of K-Ras, SARS-CoV-2 spike, β2 adrenergic receptor, and Src kinase with improved conformation-specific functions, such as enhanced binding or enzymatic activity.

Abstract To reproduce observed galaxy properties, cosmological simulations require that massive galaxies experience feedback from active galactic nuclei, which regulates star formation within those galaxies. However, the energetics and timescales of these feedback processes are poorly constrained. We combine optical, infrared, sub-millimeter and radio observations of the active galaxy VV 340a, hosting a low-power jet launched from a supermassive black hole at its center.

Abstract Environmental adaptation often involves a shift in energy utilization toward mitochondrial fatty acid oxidation, which requires carnitine. Besides dietary sources of animal origin, carnitine biosynthesis from trimethyllysine (TML) is essential, particularly for those who consume plant-based diets; however, its molecular regulation and physiological role remain elusive. Here, we identify SLC25A45 as a mitochondrial TML carrier that controls carnitine biosynthesis and fuel switching.