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Shaoyang Ge on Muck Rack

Shaoyang Ge

As seen in: Nature
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Articles

Bifidobacterium animalis subsp. lactis BL-99 ameliorates age-related intestinal hypomotility in older adults: a randomized controlled trial

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By Wen Zhao, Shaoqi Shi, Limian Zhou, Liang Zhao, Juan Chen, Yinghua Liu, Qi Zhang, Hao Zhang, Zhi Zhao, Chengying Zhang, Yixuan Li, Wei-Lian Hung, Rong Liu, Dekui Jin, Ming Zhang, Guang Li, Xinjuan Liu, xiaoxia Li, Zhaozhong Zeng, Yong Zhang, Hanglian Lan, Qiuyue Jiang, Yanling Hao, Jie Guo, Huiyuan Guo, Yuyang Zhao, Wei Xiong, Xiaokang Niu, Liwei Zhang, Jian He, Jingjing He, Ran Wang, Fazheng Ren, Shaoyang Ge
| Nature Verified
Abstract The decay of smooth muscle contractility is a major trigger of aging-related intestinal hypomotility, which imposes a substantial healthcare burden. Despite this, effective targeted therapy for this condition remains unavailable. Here, we identified the probiotic Bifidobacterium animalis subsp. lactis BL-99 as a microbiota modulator that restores gut motility through the bile acid (BA)-mediated rescue of smooth muscle contractile function.
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