Yinghua Liu
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Bifidobacterium animalis subsp. lactis BL-99 ameliorates age-related intestinal hypomotility in older adults: a randomized controlled trial
Abstract The decay of smooth muscle contractility is a major trigger of aging-related intestinal hypomotility, which imposes a substantial healthcare burden. Despite this, effective targeted therapy for this condition remains unavailable. Here, we identified the probiotic Bifidobacterium animalis subsp. lactis BL-99 as a microbiota modulator that restores gut motility through the bile acid (BA)-mediated rescue of smooth muscle contractile function.
Towards unified AI-driven fracture mechanics: the extended deep energy method (XDEM)
Abstract Physics-Informed Neural Networks (PINNs) have recently emerged as powerful tools for solving partial differential equations (PDEs), with the Deep Energy Method (DEM) proving especially effective in fracture mechanics due to its energy-based formulation. Despite these advances, existing DEM approaches require dense collocation near cracks, face stability challenges, and typically treat discrete and continuous fracture models separately.
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