xiaoxia Li

Abstract To analyze the results and trends of common eye diseases from full-term neonatal eye screenings conducted between 2016 and 2023. A retrospective study was conducted on 17,378 full-term neonates screened for eye diseases at CiXi Maternity&Child Health Care Hospital from January 2016 to December 2023. Statistical analysis and Joinpoint regression were used to assess trends in eye disease incidence, measured by the Average Annual Percent Change (AAPC).

Methods Primary objectives To evaluate the safety/tolerability of YSCH-01 injections for the treatment of patients with recurrent/refractory advanced solid tumors. To preliminarily determine the recommended clinical dose of YSCH-01 injection. Secondary objectives To observe the pharmacokinetics (PKs)/pharmacodynamics (PDs) in patients who received YSCH-01 injection. To preliminarily evaluate the efficacy of YSCH-01 injection in the treatment of recurrent/refractory advanced solid tumors.

Abstract Histone methylation plays a crucial role in various cellular processes. We previously reported the in vitro function of histone lysine demethylase 7 A (KDM7A) in osteoblast and adipocyte differentiation. The current study was undertaken to investigate the physiological role of KDM7A in bone homeostasis and elucidate the underlying mechanisms. A conditional strategy was employed to delete the Kdm7a gene specifically in osterix-expressing osteoprogenitor cells in mice.