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CXCR2 Inhibition Profoundly Suppresses Metastases and Augments Immunotherapy in Pancreatic Ductal Adenocarcinoma

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By Colin Steele, Peter Bailey, Sheila Bryson, John Connelly, Saadia A. Karim, Joshua D. G. Leach, Rosanna Upstill-Goddard, Loveena Rishi, Mona Foth, Karen McDaid, Zena Wilson, Catherine Eberlein, Juliana B. Candido, Mairi Clarke, Colin Nixon, Nigel Jamieso, Garscube Estate
| Cell Press Verified
CXCR2 Signaling at the Tumor Border Is Associated with Poor Outcome in Human PDAC KPC Mice Recapitulate the Microenvironment and CXCR2 Expression Profile of Human PDAC Depletion of Ly6G+ Cells Recapitulates the Effects of Cxcr2 Deletion CXCR2 Inhibition Results in Failure to Set up a Metastatic Niche Clinically Relevant Targeting of CXCR2 Reduces Metastases and Prolongs Survival in KPC Mice To investigate the importance of CXCR2 in human pancreatic cancer we analyzed the expression of CXCR2...
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