Shifaan Thowfeequ

Loading metrics Open Access Peer-reviewed Research Article ? This is an uncorrected proof. Citation: Stower MJ, Tyser RCV, Thowfeequ S, Zhou F, Portela M, Miti K, et al. (2025) Calcium signaling is required for anterior patterning in the mouse embryo. PLoS Biol 23(10): e3003430.

Abstract Anterior-Posterior axis formation in the mouse embryo requires the active migration of the DVE cell population at E5.5. While intracellular Ca2+ signalling has been shown to control cell migration in multiple cell contexts, it is unknown whether it is required for DVE migration. The pattern of Ca2+ activity in the mouse embryo at early peri-implantation stages is also unknown.

Introduction Ischemic heart disease is the leading causes of death worldwide.1 Much of this morbidity and mortality is attributed to the heart’s limited regenerative ability.