Shige H. Yoshimura

Special Issue Published as part of ACS Chemical Biology special issue “Lipids and Lipidation”. Introduction Click to copy section linkSection link copied! Cellular spatiotemporal control of proteins is a key determinant of protein function in signaling. (1) Crucial phenomena such as signal integration, propagation, and crosstalk are managed by the sequential recruitment of higher-order protein assemblies.

Main text (Cell Reports 43, 115048; December 24, 2024) In the originally published version of this article, the microscope image in Figure 2C “H2B cOE” was rotated and cropped to maximize the resolution of a single nucleus. However, only the Ch1 Hoechst image was rotated, inadvertently leaving all other channel images unrotated and cropped, resulting in an incorrectly merged image. Therefore, the authors have replaced the incorrectly merged image with the correctly merged image.

Keywords heterochromatin nuclear shape mechanical stress cardiomyocyte heart failure aging higher-order genomic structures cGAS/STING histone H1 chromatin compaction Research topic(s) CP: Cell biology Introduction The heart is responsible for human life by circulating blood throughout the body. Among the multiple types of cells in the heart, cardiomyocytes (CMs) play a central role in the mechanics of the heart.