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Shilei Bi

As seen in: Nature, Wiley Online Library, The BMJ
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Articles

Prophylactic tranexamic acid for the prevention of postpartum haemorrhage in women with placenta praevia: multicentre, double blind, randomised, placebo controlled, phase 3 trial

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By Lizi Zhang, Shilei Bi, Lian Chen
| The BMJ Verified
Intended for healthcare professionals Research Prophylactic...
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Caspase‐3/GSDME‐Mediated Trophoblast Pyroptosis and Reciprocal Macrophage Polarization Contribute to Inflammation in Early‐Onset Preeclampsia

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By Baoying Huang, Weinan Deng, Shilei Bi, Yifan Wang Verified
| Wiley Online Library Verified
1 Introduction Preeclampsia (PE) stands as a significant contributor to maternal and perinatal morbidity and mortality, afflicting 2 to 4 out of every 100 pregnancies worldwide [1-4]. It manifests in two distinct forms delineated by gestational age at the time of diagnosis or delivery: early-onset PE (EOPE, < 34 weeks) and late-onset PE (LOPE, ≥ 34 weeks) [5].
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KAT8-mediated H4K16ac is essential for sustaining trophoblast self-renewal and proliferation via regulating CDX2 - Nature Communications

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By Shilei Bi, Baoying Huang, Lizi Zhang, Lili Du, Haibin Wang, Dunjin Chen, Fengchao Wang
| Nature Verified
Abstract Abnormal trophoblast self-renewal and differentiation during early gestation is the major cause of miscarriage, yet the underlying regulatory mechanisms remain elusive. Here, we show that trophoblast specific deletion of Kat8, a MYST family histone acetyltransferase, leads to extraembryonic ectoderm abnormalities and embryonic lethality.
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