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Articles by Shumin Li
An LRR-truncated NLR natural variant confers dual resistance to drought and blast in rice
Abstract Climate change threatens global food security by imposing concurrent abiotic and biotic stresses on major crops such as rice. Genetic resources conferring dual resistance to drought and blast disease are rare, limiting the development of climate-resilient crops. Here, using a genome-wide association study, we identify NLR8-Hap2, a natural allele of the rice resistance gene NLR8 that enhances resistance to drought and blast disease.
The clinical effects of probiotic supplementations on metabolic syndrome: a systematic review and meta-analysis
Abstract Background/Objectives: Probiotics have attracted much attention due to their ability to modulate nutrient metabolism or immunomodulatory. This study aims to evaluate the efficacy of probiotic supplementation in the treatment of metabolic syndrome. Methods: PubMed, Web of Science, Embase, and Cochrane Library were systematically searched searched for eligible clinical trials published from database inception to July 2024. STATA/SE 14.0 software was used for statistical analysis.
Polyphyllin I Orchestrates Autophagy to Reprogram the Tumour Immune Microenvironment and Abrogate Cisplatin Resistance in Non-Small Cell Lung Cancer
Zongxu Liu and Yanping Li contributed equally to this study. Conflicts of Interest The authors declare no conflicts of interest. Data Availability Statement The data that support the findings of this study are available from the corresponding author upon reasonable request. Peer Review For transparency, the peer review documents associated with this article are available at https://doi.org/10.1111/1440-1681.70149.
Earliest mimicking of flowering plants by insects
Supporting Information Filename Description ins70323-sup-0001-SuppMat.docx1.1 MB Note S1 Visual defensive strategies in fossil insects. Note S2 Comparative evaluation of angiosperm leaf mimicry across the Principiala genus group from Kachin amber. Fig. S1 Photographs of leaf specimens collected from Kachin amber. Fig. S2 Dissimilarity values between insect mimics and their models. Fig. S3 Data distribution of the Feret's diameter of forewing cells. Fig.
Reply to Comment by Cao and Yu on “Tidal Modulation of the Fraser River Plume”
S., & Pawlowicz, R. (2026). Reply to comment by Cao and Yu on “tidal modulation of the Fraser River plume”. Journal of Geophysical Research: Oceans, 131, e2026JC024151. Li, https://doi.org/10.1029/2026JC024151 References , & (2025). Tidal modulation of the Fraser River plume. Journal of Geophysical Research: Oceans, 130(1), e2024JC021432. https://doi.org/10.1029/2024jc021432 , , , , & (2017). Advection, surface area, and sediment load of the Fraser River plume under variable wind and river forcing.
Gungnir codec enabling high error-tolerance and low-redundancy DNA storage through substantial computing power
Abstract DNA has emerged as a compelling archival storage medium, offering unprecedented information density and millennia-scale durability. Despite its promise, DNA-based data storage faces critical challenges due to error-prone processes during DNA synthesis, storage, and sequencing. In this study, we introduce Gungnir, a codec system using the proof-of-work idea to address substitution, insertion, and deletion errors in a sequence.
Dose-resolved control of somatic reprogramming by Rora
Keywords Rora nuclear receptors somatic cell reprogramming dose-dependent regulation Introduction Direct reprogramming of somatic cells to induced pluripotent stem cells (iPSCs) by transcriptional factors resets cell identity but remains constrained by cell-intrinsic barriers and incomplete control of chromatin and signaling (Chen et al., 2011; Takahashi et al., 2007; Takahashi and Yamanaka, 2006; Wang et al., 2019).
Determination of Ultrasound Reference Values for Diagnosing Low Muscle Mass in Older Chinese Adults
1 Introduction Sarcopenia, an age-related condition marked by a decline in muscle strength and function, significantly increases the risk of adverse health outcomes, including falls, disability and mortality [1]. The prevalence of sarcopenia among older adults worldwide has been estimated to range from 10% to 27%, with higher rates observed in hospital settings compared with community-dwelling populations [2].
Multi-ancestry genome-wide association analyses of polycystic ovary syndrome - Nature Genetics
Corneal epithelial thickness can reflect the stage of Parkinson’s disease and the severity of dry eye
Abstract Purpose: To systematically analyze corneal epithelial thickness (CET) distribution in Parkinson’s disease (PD) using anterior segment optical coherence tomography (AS-OCT) and investigate its correlation with disease stage and dry eye severity. Methods: This cross-sectional study enrolled 60 PD patients (120 eyes) and 29 age- and sex-matched healthy controls (58 eyes).
The adoption paradox for veterinary professionals in China: high use of artificial intelligence despite low familiarity
Abstract Introduction: The global integration of artificial intelligence (AI) into veterinary medicine is advancing, yet its adoption in major markets like China remains uncharacterized. This study aimed to provide the first exploratory analysis of AI perception and adoption among veterinary professionals in China. Methods: A cross-sectional survey was administered to 455 veterinary professionals in China from May to July 2025.
TaGW2-TaVOZ1 module regulates wheat salt tolerance via both E3 ligase-dependent and -independent pathways
Abstract Wheat production is limited by the rapid expansion of salinized arable land worldwide. Identification of the molecular mechanisms that underlie the salt stress response is of great importance. Here, we uncovered the NAC-type transcription factor, TaVOZ1, as a positive regulator of wheat salt tolerance. Its overexpression could enhance yield and biomass production under salt stress, while TaVOZ1 knockdown attenuates salt tolerance.
Targeting Cystine Metabolism in the Lung Cancer Environment Enhances the Efficacy of Immune Checkpoint Inhibition
1 Introduction Non-small cell lung cancer (NSCLC) is the most common histologic subtype of lung cancer, accounting for ≈80–85% of all cases.[1] In recent years, with the rapid advancement and application of immune checkpoint inhibitors (ICIs) represented by PD-1/PD-L1 antibodies in cancer treatment, many patients with advanced NSCLC have achieved a long-term survival.[2, 3] Several clinical studies have shown that ≈20% of patients with advanced lung cancer show a long-term clinical benefit...
Architecture of genome-wide transcriptional regulatory network reveals dynamic functions and evolutionary trajectories in Pseudomonas syringae
eLife assessment This work advances our understanding of transcriptional regulation of virulence and metabolic pathways in plant pathogenic bacteria. Solid evidence for the claims is provided by computational analysis of newly generated data on the genome-wide binding of 170 transcription factors to their target genes, together with experimental validation of the biological functions of some of these transcription factors.
Tidal Modulation of the Fraser River Plume
Supporting Information References , , & (2020). Modeling the dynamics of small-scale river and creek plumes in tidal waters. Journal of Geophysical Research: Oceans, 125(7), e2019JC015737. https://doi.org/10.1029/2019jc015737 , , , , , & (2019). Using overlapping VIIRS scenes to observe short term variations in particulate matter in the coastal environment. Remote Sensing of Environment, 233, 111367. https://doi.org/10.1016/j.rse.2019.111367 (2012).
The E3 ubiquitin ligase TaGW2 facilitates TaSnRK1γ and TaVPS24 degradation to enhance stripe rust susceptibility in wheat
INTRODUCTION Wheat (Triticum aestivum L.) is a staple food for nearly 40% of the global population and serves as a primary source of carbohydrates and proteins for humans. As the global population is predicted to reach 10 billion by 2050, a minimum 60% increase in wheat production will be necessary to meet food demands. Therefore, safe and efficient wheat production is crucial to ensure food security in China and worldwide (Acevedo-Garcia et al., 2017; Eckardt et al., 2023; Hickey et al., 2019).
AutoPM3: Enhancing Variant Interpretation via LLM-driven PM3 Evidence Extraction from Scientific Literature
Abstract Rare diseases, affecting 300 million people globally, often result from genetic variants. Whole-genome sequencing has made variant detection more cost-effective, but interpreting these variants remains challenging. Current clinical practice combines quantitative evidence and literature, which is complex and time-consuming.
1413 An integrated tumor, immune and genetic landscape of pleural mesothelioma to unleash effective immunotherapy avenues
http://creativecommons.org/licenses/by-nc/4.0/ This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial.
Global transcription factors analyses reveal hierarchy and synergism of regulatory networks and master virulence regulators in Pseudomonas aeruginosa
Abstract The transcription factor regulatory network in Pseudomonas aeruginosa is complex and involves multiple regulators that respond to various environmental signals and physiological cues by regulating gene expression. However, the biological functions of at least half of its 373 putative transcription factors (TFs) remain uncharacterised. Herein, chromatin immunoprecipitation sequencing (ChIP-seq) was used to investigate the binding sites of 172 TFs in the P. aeruginosa PAO1 strain.
GDH1 exacerbates renal fibrosis by inhibiting the transcriptional activity of peroxisome proliferator‐activated receptor gamma
Introduction Chronic kidney disease (CKD) affects 10–13% of the population worldwide and is one of the leading causes of death. According to associated studies, by 2040 it's predicted to overtake all other causes of mortality to rank fifth. CKD treatment is limited to delaying progression, preventing sequelae and complications, and consists primarily of conservative or alternative treatments (peritoneal dialysis, hemodialysis, and kidney transplantation) [[1-3]].
Arbuscular Mycorrhizal Fungal Interacted with Biochar and Enhanced Phosphate-Solubilizing Microorganism Abundance and Phosphorus Uptake in Maize
All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.
Establishment of Canine Oral Mucosal Melanoma Cell Lines and Their Xenogeneic Animal Models
All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.
Exploring the Multi-Sensory Coupling Relationship of Open Space on a Winter Campus
All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.
Sustainability | Free Full-Text | Response of Soil Nitrogen-Cycling Genes to the Coupling Effects of Arbuscular Mycorrhizal Fungi Inoculation and Biochar Application in Maize Rhizosphere
All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.
A Study of the Effects of Historical Block Context on Soundscape Perception
All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.
Architecture of genome-wide transcriptional regulatory network reveals dynamic functions and evolutionary trajectories in Pseudomonas syringae
Abstract The model Gram-negative plant pathogen Pseudomonas syringae utilises hundreds of transcription factors (TFs) to regulate its functional processes, including virulence and metabolic pathways that control its ability to infect host plants. Although the molecular mechanisms of regulators have been studied for decades, a comprehensive understanding of genome-wide TFs in P. syringae remains limited. Here, we investigated the binding characteristics of 170 of 301 annotated TFs through ChIP-seq.
The effects of budesonide inhalation treatment
Back to Journals » International Journal of General Medicine » Volume 17 Original Research General Medicine Authors Niu Y, Cao M, Li S, Mo J, Zhu Z, Wang H Received 20 December 2023 Accepted for publication 26 March 2024 Published 29 March 2024 Volume 2024:17 Pages 1253—1261 DOI https://doi.org/10.2147/IJGM.S455872 Checked for plagiarism Yes Review by Single anonymous peer review Peer reviewer comments 2 Editor who approved publication: Dr Woon-Man Kung Yueying Niu,1 Mengqing Cao,1 Shumin...
ClusterV-Web: A User-Friendly Tool for Profiling HIV Quasispecies and Generating Drug Resistance Reports from Nanopore Long-Read Data
Abstract Summary: Third-generation long-read sequencing is an increasingly utilized technique for profiling HIV quasispecies and detecting drug resistance mutations due to its ability to cover the entire viral genome in individual reads. Recently, the ClusterV tool has demonstrated accurate detection of HIV quasispecies from Nanopore long-read sequencing data. However, the need for scripting skills and a computational environment may act as a barrier for many potential users.
CellContrast: Reconstructing Spatial Relationships in Single-Cell RNA Sequencing Data via Deep Contrastive Learning
Abstract A vast amount of single-cell RNA-seq (SC) data has been accumulated via various studies and consortiums, but the lack of spatial information limits its analysis of complex biological activities. To bridge this gap, we introduce cellContrast, a computational method for reconstructing spatial relationships among SC cells from spatial transcriptomics (ST) reference.
Multi-Trip Vehicle Routing Problem with Time Windows and Resource Synchronization on Heterogeneous Facilities
Abstract : Inspired by long-distance road transport in industrial logistics in China, this paper studies a simultaneous loading scheduling and vehicle routing problem over a multi-workday planning horizon. Industrial cargo often requires specialized facilities, and these facilities vary in performance and quantity and are subject to available time constraints. Consequently, achieving coordinated optimization of vehicle routing and loading scheduling becomes a significant challenge in practice.
Carleman estimates and some inverse problems for the coupled quantitative thermoacoustic equations by partial boundary layer data. Part II: Some inverse problems
Introduction We investigate the so called quantitative thermoacoustic tomography process (e.g., [ 1-4 ] and the references therein).
Lactobacillus rhamnosus GG Promotes Recovery of the Colon Barrier in Septic Mice through Accelerating ISCs Regeneration
Open AccessArticle by Lufang Chen 1,2, Shumin Li 1, Chunting Peng 1, Qifeng Gui 1,2, Jinyou Li 1,2, Zherong Xu 1 and Yunmei Yang 1,2,* 1 Department of Geriatrics, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310003, China 2 Key Laboratory of Diagnosis and Treatment of Aging and Physic-Chemical Injury Diseases of Zhejiang Province, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310003, China * Author to whom correspondence...
Controllable Synthesis of MOFs-derived Porous and Tubular Bimetallic Fe-Ni Phosphides for Efficient Electrocatalytic Water Splitting
Controllable Synthesis of MOFs-derived Porous and Tubular Bimetallic Fe-Ni Phosphides for Efficient Electrocatalytic Water Splitting Shumin Li, Jingyun Wang, Xiaoyu Lv, Song Zheng, Jin Wang and Zhengquan Li Abstract To boost the electrocatalytic performance, the efficient electrocatalysts generally call for an appropriate absorption/desorption intensity to the intermediates, and a favorable transportation capability of mass and electrons.
Symphonizing pileup and full-alignment for deep learning-based long-read variant calling
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Symphonizing pileup and full-alignment for deep learning-based long-read variant calling
Symphonizing pileup and full-alignment for deep learning-based long-read variant calling Zhenxian Zheng, Shumin Li, Junhao Su, Amy Wing-Sze Leung, Tak-Wah Lam, Ruibang Luo bioRxiv 2021.12.29.474431; doi: https://doi.org/10.1101/2021.12.29.474431
Metal‐Organic Frameworks Derived Titanium Oxides via Soft Interface Adaptive Transformation
Research Article Jing Wang, Jing Wang School of Chemistry and Molecular Engineering, East China Normal University, Shanghai, 200241 P. R. China Key Laboratory of Jiangsu Province for Chemical Pollution Control and Resources Reuse, School of Environmental and Biological Engineering, Nanjing University of Science and Technology, Nanjing, 210094 P. R.
Synthesis of Substrate-bound Seaweed-like Au Nanowires with Amino Silane Coupling Agents
Synthesis of Substrate-bound Seaweed-like Au Nanowires with Amino Silane Coupling Agents You have access to this article Please wait while we load your content... Something went wrong. Try again?
Nuclear receptor PXR targets AKR1B7 to protect mitochondrial metabolism and renal function in AKI
A nuclear option for acute kidney injury Acute kidney injury is a life-threatening health problem with many potential causes such as hypoxic injury, toxins, and sepsis. Patients can recover with supportive care, but they may have long-lasting kidney damage that increases the risk of chronic kidney disease, and there is no specific targeted treatment. Yu et al.
Correction: The hMLH1 −93G>A Polymorphism and Risk of Ovarian Cancer in the Chinese Population
After publication of this article [1], a reader noted that the description of Fig 1A findings in the Results section does not agree with the results reported in the figure. The authors clarified that there are errors in the Results section text such that allele references are incorrect.
Facile Generation of Carbon Quantum Dots in MIL-53(Fe) Particles as Localized Electron Acceptors for Enhancing Their Photocatalytic Cr(VI) Reduction
Metal-organic frameworks (MOFs) photocatalysts have shown promising application in photocatalytic Cr(VI) reduction, but their activities are still restrained by severe charge recombination. To overcome this limitation, herein we propose that the incorporation of cocatalysts as electron acceptors inside MOF pores can possess a better chance to separate photogenerated electrons, compared with traditional methods to cover cocatalysts on the MOF surface.
Plasmonic and photo-electrochemical enhancements of AuAg@Au/RGO-C3N4 nanocomposite for the detection of DA
Plasmonic photocatalyst has attracted tremendous attention due to its valuable theory study and promising practical application in solar cells, functional composites and sensors. Herein, an interesting RGO-C3N4 supported AuAg core-Au shell (AuAg@Au) nanocomposite has been reported.
Self-supported porous 2D AuCu triangular nanoprisms as model electrocatalysts for ethylene glycol and glycerol oxidation
Shape-controlled synthesis of self-supported metallic nanocrystals with abundant active surface areas is of vital importance in the design and fabrication of novel outstandingly excellent electrocatalysts. Motivated by this, we herein reported our works in the synthesis of self-supported porous 2D AuCu triangular nanoprisms via a facile wet-chemical method.
Nonenzymatic electrochemical detection of rutin on Pt nanoparticles/graphene nanocomposites modified glassy carbon electrode
In this article, a nonenzymatic electrochemical sensor based on chemically reduced graphene oxide (RGO) and Pt nanoparticles (PtNPs) modified glassy carbon electrode has been fabricated and used to determine rutin. The nanocomposites of PtNPs/RGO were characterized by transmission electron microscopy and X-ray diffraction, and the electrochemical behavior of rutin on PtNPs/RGO were demonstrated by cyclic voltammetry and different pulse voltammetry.
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