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Articles by Shumin Sun
Chemo-metallo nanodrivers for spatiotemporally controlled in situ vaccination
Abstract INTRODUCTION RESULTS DISCUSSION MATERIALS AND METHODS Acknowledgments Supplementary Materials REFERENCES Information & Authors Metrics & Citations View Options References Figures Tables Media Share This article has 0 eLetter . Abstract In situ cancer vaccines exhibit promising therapeutic potential; however, their efficacy is constrained by limited antigen release, suboptimal spatiotemporal immune coordination, and adaptive immune resistance.
Ferroptosis in kidney disease
Abstract Kidney disease is a growing global public health concern that is associated with high rates of severe morbidity and mortality. Accumulating preclinical and clinical evidence suggests that ferroptosis, an iron-dependent form of regulated cell death characterized by lethal lipid peroxidation, drives the pathogenesis and progression of diverse kidney disorders, including acute kidney injury, chronic kidney disease, renal cell carcinoma and autosomal-dominant polycystic kidney disease.
Zinc accumulation in macrophages exacerbates metabolic dysfunction-associated steatotic liver disease progression
Abstract Metabolic dysfunction-associated steatotic liver disease (MASLD) affects over 1 billion people globally, yet the role of trace elements in its progression remains poorly defined. Here, we identify “macrophage zinc trapping” (i.e., selective zinc accumulation in hepatic macrophages despite systemic zinc depletion) as a critical driver of MASLD. In a cohort of 1069 individuals with MASLD, we found that serum zinc levels were inversely correlated with the disease severity.
A Universal Precipitation-Transformation Strategy Toward Low-Defect Prussian Blue Analogs for High-Performance Sodium-Ion Batteries
Conflicts of Interest The authors declare no conflict of interest. Data Availability Statement The data that support the findings of this study are available from the corresponding author upon reasonable request. Supporting Information Filename Description smll75088-sup-0001-SuppMat.docx26.4 MB Supporting File: smll75088-sup-0001-SuppMat.docx. References 1, , , et al., “Prussian Blue Analogs for Sodium-Ion Batteries: Past, Present, and Future,” Advanced Materials 34 (2022): 2108384.
Network pharmacology and experimental analysis of Paeoniae radix Rubra and moutan cortex for SLE treatment
Abstract Paeoniae Radix Rubra (Chishao, CS) and Moutan Cortex (Mudanpi, MDP) are frequently utilized in the clinical management of SLE, yet the molecular mechanisms underlying their therapeutic effects in SLE remain to be fully elucidated. This study aims to investigate the mechanism of CS-MDP in treating SLE using a network pharmacology and experimental approach. The potential active ingredients and targets of CS-MDP were obtained through screening the TCMSP database.
Lactate‐Modulating Nanoreactors Facilitate Self‐Amplifying Pyroptosis and the cGAS‐STING Cascade for Potentiated Catalytic‐Immunotherapy
1 Introduction Hepatocellular carcinoma (HCC) represents a significant cause of cancer-related mortality globally, with its disease burden remaining consistently high.[1] Local treatments such as transcatheter arterial embolization (TAE) or transarterial chemoembolization (TACE) are the preferred therapeutic modalities for patients with intermediate to advanced stage HCC.[2] TAE/TACE involves percutaneous superselective catheterization of the hepatic arteries supplying hepatocellular...
Detachable Fluorinated Phthalocyanine Aggregates for Carrier‐Free PDT: Effect of Axial Symmetry on Dynamic Morphological Adjustment and Photodynamic Efficiency
Conflict of Interest The authors declare no conflict of interest. Supporting Information Filename Description adfm70959-sup-0001-SuppMat.docx12 MB Supporting Information References 1a) , , , , ACS Nano 2023, 17, 7979; b) , , , , , Coordin. Chem. Rev. 2024, 507, 215756; c) , , , , , , , , , , J. Am. Chem. Soc. 2025, 147, 3161; d) , , , , Exploration 2023, 3, 20220001. 2a) , , , , , , Chem. Soc. Rev. 2020, 49, 1041; b) , , , , , , Coordin. Chem. Rev. 2024, 510, 215863. c) , , , , , , , , BMEMat 2023, 1, 12006.
Degradation of patulin in aqueous solution and apple juice by titanium dioxide/graphitic carbon nitride: efficiency, quality and safety
Abstract A titanium dioxide/graphitic carbon nitride composite (TiO2/g-C3N4; TOCN) was utilized for the degradation of patulin (PAT). The introduction of carbon nitride into TOCN narrowed the band gap of titanium dioxide (TiO2), thereby enhancing the utilization of the composite with visible light. Patulin at a concentration of 250 μg/kg in aqueous solution and apple juice was degraded respectively by 100% and 85.4% under visible light.
Multi‐Core Functional Microspheres for Osteoporotic Bone Defects Therapy: From Local Treatment to Systematic Relief
Conflict of Interest The authors declare no conflict of interest. Supporting Information Filename Description adfm202500115-sup-0001-SuppMat.docx6.2 MB Supporting Information References 1a) , , , , , , , , Bone Res. 2024, 12, 4; b) , , N. Engl. J. Med. 2016, 374, 254; c) , , , , Nat. Rev. Endocrinol. 2014, 10, 338. 2a) , , , , , , , Angew. Chem. Int. Ed. Engl. 2024, 63, 202318459; b) , , , , , , , , , , , , , ACS Nano 2023, 17, 6466. 3, , , , , , , , , , ACS Nano 2021, 15, 13041.
Optimal Scheduling of Integrated Energy System Based on Carbon Capture-Power to Gas Combined Low-Carbon Operation
1. Introduction To reduce the impact of global warming caused by carbon emissions, energy conservation and emission reduction in industrial parks are important [1,2,3]. Therefore, it is essential to realize the energy transformation of industrial parks. Integrated energy systems (IES) improve energy efficiency by coupling various energy sources to achieve multi-energy complementarity [4,5,6,7].
Self-Cascaded Pyroptosis-STING Initiators for Catalytic Metalloimmunotherapy
1. Introduction Click to copy section linkSection link copied! Immunotherapy, exemplified by immune checkpoint blockade (ICB) therapy, has revitalized cancer treatments. (1,2) Unfortunately, there are still challenges impeding response rates and treatment outcomes, such as an immunosuppressive network within the tumor microenvironment (TME) and inadequate tumor immunogenicity.
Manganese Galvanic Cells Intervene in Tumor Metabolism to Reinforce cGAS‐STING Activation for Bidirectional Synergistic Hydrogen‐Immunotherapy
Conflict of Interest The authors declare no conflict of interest. Supporting Information Filename Description adma202414929-sup-0001-SuppMat.docx3.3 MB Supporting Information References 1a) , , Nat. Rev. Immunol. 2024, 24, 399; b) , , , , , , , , , , Nat. Rev. Clin. Oncol. 2023, 20, 116. 2a) , , , , Nat. Cancer 2024, 5, 557; b) , , Nat. Rev. Bioeng. 2023, 1, 125; c) , , , , , , , , , , ACS Nano 2024, 18, 19756. 3a) , , , , , , , , , , Nature 2024, 625, 585; b) , , Nat. Cancer 2022, 3, 1452.
The zinc transporter Slc30a1 (ZnT1) in macrophages plays a protective role against attenuated Salmonella
Editor's evaluation The important work described in this manuscript reveals a new pathway in nutritional immunity: the zinc transporter SLC30A1 in the antimicrobial function of macrophages. Authors provide convincing evidence that zinc homeostasis promotes macrophage cell function that is not conducive to the intracellular proliferation of Salmonella, specifically attenuated Salmonella. This will be of interest to readers involved in pathogenesis, immunity, and bacteriology.
The Intestinal Transporter SLC30A1 Plays a Critical Role in Regulating Systemic Zinc Homeostasis
1 Introduction As an essential trace element, zinc regulates a wide range of cellular processes, including cell proliferation, DNA synthesis, gene transcription, and protein synthesis. According to the World Health Organization,[1] zinc deficiency is a global public health problem, causing diverse symptoms such as impaired growth and/or development, immune system disorders, and impaired neurological function.[2, 3] Zinc homeostasis is therefore critical for maintaining health.
Modulating the Electronic Structure of MnNi2S3 Nanoelectrodes to Activate Pyroptosis for Electrocatalytic Hydrogen‐Immunotherapy
Conflict of Interest The authors declare no conflict of interest. Supporting Information Filename Description adma202412925-sup-0001-SuppMat.docx13.2 MB Supporting Information References 1a) , , , , , ACS Nano 2019, 13, 8505; b) , , , Science 1975, 190, 152; c) , , , Adv. Healthcare Mater. 2019, 8, 1900463. 2a) , , , , Biochem. Biophys. Res. Commun. 2020, 522, 965; b) , , , , , , , , , , , Adv. Mater. 2023, 35, 2209589. 3a) , , , , , , , , , , , Nat. Commun.
High fat intake aggravates hyperlipidemia and suppresses fatty liver symptoms induced by a high-sucrose diet in rats
High fat intake aggravates hyperlipidemia and suppresses fatty liver symptoms induced by a high-sucrose diet in rats† Overconsumption of sucrose or fat is widely acknowledged as a prominent feature of unhealthy dietary patterns. Both factors commonly co-occur and are recognized as hallmarks of the Western diet, which is an important contributor to non-communicative diseases. In this study, we investigated the hazards of high sucrose or fat intake, either alone or in combination.
Thermo-Alkali-Tolerant Recombinant Laccase from Bacillus swezeyi and Its Degradation Potential against Zearalenone and Aflatoxin B1
Download Hi-Res ImageDownload to MS-PowerPointCite This:J. Agric. Food Chem. 2024, XXXX, XXX Terms & Conditions Most electronic Supporting Information files are available without a subscription to ACS Web Editions. Such files may be downloaded by article for research use (if there is a public use license linked to the relevant article, that license may permit other uses).
Weighted Pseudo-θ-Almost Periodic Sequence and Finite-Time Guaranteed Cost Control for Discrete-Space and Discrete-Time Stochastic Genetic Regulatory Networks with Time Delays
1. Introduction Genetic regulatory networks (GRNs) have been widely recognized due to their possible usages [ 1 ]. GRNs are actually a complex dynamical system that describes the regulatory mechanisms of DNA, mRNA, and protein interactions in biological systems at the molecular level [ 2 , 3 ].
The zinc transporter Slc30a1 in macrophages plays a protective role against Salmonella infection
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An Enhanced Enzyme-Linked Aptamer Assay for Detection of Zearalenone Based on Gold Nanoparticles
An Enhanced Enzyme-Linked Aptamer Assay for Detection of Zearalenone Based on Gold Nanoparticles A novel enhanced enzyme-linked aptamer assay （ELAA）for detection of zearalenone (ZEN) was developed based on gold nanoparticles (AuNPs) modified with aptamer and horseradish peroxidase(HRP). In this assay, the aptamer was used as recognition probe to competitively bind with coated ZEN-BSA on microplate and ZEN in samples.
Circadian rhythm-dependent induction of hepatic lipogenic gene expression in rats fed a high-sucrose diet
Shumin Sun‡1, Fumiaki Hanzawa§, Daeun Kim‡, Miki Umeki¶, Syunsuke Nakajima‡, Kumiko Sakai‖, Saiko Ikeda§, Satoshi Mochizuki** and Hiroaki Oda‡2 ‡Laboratory of Nutritional Biochemistry, Nagoya University, Nagoya 464-8601, Japan §Department of Nutritional Science, Nagoya University of Arts and Sciences, Nisshin 470-0196, Japan ¶Faculty of Food Science and Nutrition, Beppu University, Beppu 874-8501, Japan ‖Faculty of Medicine, Oita University, Yufu 879-5593, Japan **Faculty of Education, Oita...
Circadian rhythm-dependent induction of hepatic lipogenic gene expression in rats fed a high-sucrose diet
Shumin Sun1, Fumiaki Hanzawa2, Daeun Kim1, Miki Umeki3, Syunsuke Nakajima1, Kumiko Sakai4, Saiko Ikeda2, Satoshi Mochizuki5 and Hiroaki Oda1* 1Laboratory of Nutritional Biochemistry, Nagoya University, Japan 2Department of Nutritional Science, Nagoya University of Arts and Sciences, Japan 3Faculty of Food Science and Nutrition, Beppu University, Japan 4Faculty of Medicine, Oita University, Japan 5Faculty of Education, Oita University, Japan ↵* Corresponding author; email:...
Delayed first active-phase meal, a breakfast-skipping model, led to increased body weight and shifted the circadian oscillation of the hepatic clock and lipid metabolism-related genes in rats fed a high-fat diet
The circadian clock is closely related to human health, such as metabolic syndrome and cardiovascular disease. Our previous study revealed that irregular feeding induced abnormal lipid metabolism with disruption of the hepatic circadian clock. We hypothesized that breakfast skipping induces lipid abnormalities, such as adiposity, by altering the hepatic circadian oscillation of clock and lipid metabolism-related genes.
Asymmetric supercapacitors based on NiCo2O4/three dimensional graphene composite and three dimensional graphene with high energy density
A NiCo2O4 nanoparticle/three dimensional porous graphene (NiCo2O4/3D-G) composite was synthesized through a facile hydrothermal method without precipitant combined with subsequent annealing treatment. X-ray diffraction, X-ray photoelectron spectroscopy, and transmission electron microscopy analyses indicate that the NiCo2O4 nanoparticles were tightly anchored on the graphene sheets in the NiCo2O4/3D-G composite.
Time and temperature dependent multiple hierarchical NiCo2O4 for high-performance supercapacitors
A multiple hierarchical NiCo2O4 (denoted as P-100), which was constructed of nanosheets covered with nanowires, was obtained by a facial hydrothermal method with the combination of annealing treatment at 300°C. The hydrothermal temperature and reaction time play key roles in the formation of the unique hierarchical NiCo2O4 based on the morphology evolution. As a supercapacitor electrode material, the obtained P-100 displays a high specific capacitance of 1393 F•g−1 at 0.5 A•g−1.
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