Shun Wang
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Articles by Shun Wang
Decoupling Flavor From Spoilage: A Microbial and Chemical Framework for Volatile Sulfur Compounds and Biogenic Amines in Washed-Rind and Aged Cheeses
1 Introduction Few foods embody a paradox as sharply as ripened cheese.
Disruption of ACTG1 potentiates anti-TIM-3 immunotherapy by reprogramming the immunosuppressive microenvironment via the CSF3/CSF3R axis in pancreatic cancer
Abstract Background: The limited immune infiltration observed in pancreatic ductal adenocarcinoma (PDAC) is a major factor contributing to immunotherapy resistance and the consistently poor prognosis. Hence, identifying novel therapeutic targets and developing effective combination strategies to overcome immunotherapy resistance represent urgent and unmet clinical needs. Methods: The gene expression datasets and corresponding clinical information were collected from TCGA, GEO and ICGC.
Hippocampal AdipoR1 regulates the microglial response and delays disease progression in a mouse model of Alzheimer’s disease
Abstract Adiponectin, a key regulator of peripheral lipid metabolism, exhibits a positive correlation between its reduced peripheral and central levels and cognitive function in Alzheimer’s disease (AD). Previous studies suggest that adiponectin primarily crosses the blood–brain barrier to exert its neuroprotective and anti-inflammatory effects within the brain. However, the detailed mechanisms through which adiponectin improves cognitive function in AD remain unclear.
Evolution of Microstructure and Thermal Properties of GAO–GZO TBC After Annealing at 1300°C
Conflicts of Interest The authors declare no conflicts of interest. References 1, , and , “Thermal Barrier Coatings for Gas-Turbine Engine Applications,” Science 296, no. 5566 (2002): 280–284, https://doi.org/10.1126/science.1068609. 2, , , et al., “Design Principles of Composite Oxides for High-Temperature Thermal and Environmental Barrier Coatings: A Review,” Journal of the American Ceramic Society 109, no. 6 (2026): e70887, https://doi.org/10.1111/jace.70887.
Deep learning predicts gene rearrangements from histopathology in large B-cell lymphoma
Abstract Large B-cell lymphomas are molecularly heterogeneous mature B-cell neoplasms in which assessment of MYC, BCL2, and BCL6 rearrangement status contributes to integrated diagnosis, risk stratification, and treatment planning. Fluorescence in situ hybridization (FISH) remains the standard method for detecting these rearrangements but can be time-consuming, tissue-consuming, and resource-intensive.
The ketogenic diet in Parkinson’s disease: mechanisms, evidence, and clinical practice
Abstract Parkinson’s disease (PD) represents the second most common neurodegenerative disorder across the globe. Conventional levodopa treatment can only alleviate disease-related symptoms and fails to restrain the progressive deterioration of PD.
Gut-brain immune dysregulation in Parkinson’s disease: a hypothesis-forming narrative review of trained immunity
Abstract Parkinson’s disease (PD) is increasingly understood as a multisystem disorder in which gastrointestinal dysfunction, immune remodeling, protein aggregation, and central neurodegeneration interact across the disease course. Although gut microbiota alterations are repeatedly reported in PD, taxonomic differences alone do not explain how peripheral ecological signals acquire neurological relevance.
Van der Waals surface reconstruction for oriented epitaxial growth of two-dimensional metallic oxides
Abstract Hybrid integration of two-dimensional single-crystalline metal oxides, including semiconductors, dielectrics, ferroelectrics and ferromagnetics, with silicon circuits enables functionalities such as spintronics and neuromorphic and quantum computing, forming a key part of the ‘More-than-Moore’ roadmap. However, synthesizing two-dimensional metal oxide single-crystal films has remained challenging.
Flame-Retardant Quasi-Solid-State Electrolytes From Self-Assembled Azolate Hybrid Frameworks for Highly Safe Lithium Batteries
1 Introduction With the accelerating global energy transition, lithium-ion batteries (LIBs) have become indispensable for electric vehicles and grid-scale energy storage [1-4]. However, the increasing prevalence of high-temperature and extreme operating environments has exposed fundamental limitations in conventional battery technologies, making the development of thermally robust and intrinsically safe lithium batteries an urgent challenge [5, 6].
Depression and Longitudinal Frailty Trajectories in Middle-Aged and Older Adults with Chronic Pain: A 8-Year National Cohort Study in China
Back to Journals » Psychology Research and Behavior Management » Volume 19 Authors Zhang H, Wang A, Wang S , Feng G, Wang L, Deng L Received 10 June 2026 Accepted for publication 7 September 2026 Published 16 September 2026 Volume 2026:19 630081 DOI https://doi.org/10.2147/PRBM.S630081 Checked for plagiarism Yes Review by Single anonymous peer review Peer reviewer comments 2 Editor who approved publication: Professor Mei-Chun Cheung Haotian Zhang, Aiqi Wang, Shun Wang, Guoyan Feng, Lu Wang,...
Effect of retaining wall on soil moisture and temperature distribution in open pit coal mine dump: experiment and simulation
Abstract In ecologically fragile arid and semi-arid mining regions, open-pit mining has created extensive spoil dumps characterized by extreme soil moisture and temperature regimes, constituting the primary challenge for vegetation restoration and ecological rehabilitation. To address this challenge, there is an urgent need to explore novel rehabilitation approaches that reconcile energy development with ecological conservation.
A compatible gravity-driven organoid perfusion (GDOP) platform for drug screening with sensitivity and toxicity process evaluation
Abstract High-throughput experiments, unidirectional fluid replacement, real-time process monitoring, and simultaneous drug sensitivity and toxicity tests are hard to achieve on most existing tumor organoid chips. Here, we developed a gravity-driven organoid perfusion (GDOP) platform facilitating scalable throughput and supporting drug sensitivity and toxicity assessment on organoids.
Dual-mode superconducting diode effect enabled by in-plane and out-of-plane magnetic field
Abstract The discovery of the superconducting diode effect (SDE) is recognised as a step forward in the development of superconducting electronics. Despite the diversity in the hosting materials and device designs, SDE is usually operated in a single mode which is enabled by either out-of-plane or in-plane magnetic field/magnetization.
Grain ultra-refinement–induced multilayer co-enrichment of Cr and Si in the rust layer enhances corrosion resistance of weathering steel
Abstract In this work, the formation and evolution of the rust layer on coarse-grained (25.0 µm) and ultrafine-grained (0.5 µm) weathering steels were investigated through wet/dry cyclic corrosion test in 3.5 wt% NaCl solution, aiming to elucidate the synergistic effect of alloying elements Cr and Si on the corrosion resistance of weathering steel.
Monotonic and Cyclic Shear Behaviors of EPS Geofoam: Experiments and Hypoplastic Modeling
Data Availability Statement The data that support the findings of this study are available from the corresponding author upon reasonable request. References 1 and , “ Full-Scale Testing of an EPS Geofoam Cover System to Protect Pipelines at Locations of Lateral Soil Displacement,” in Pipelines 2014: From Underground to the Forefront of Innovation and Sustainability (ASCE, 2014): 605–615, https://doi.org/10.1061/9780784413692.056.
Exosomes Regulate the NLRP3/Caspase-1/IL-1β Signaling Pathway in Park
Back to Journals » Neuropsychiatric Disease and Treatment » Volume 22 Authors Zhang T, Du H, Wang S Received 10 December 2025 Accepted for publication 19 February 2026 Published 28 February 2026 Volume 2026:22 Pages 1—16 DOI https://doi.org/10.2147/NDT.S587802 Checked for plagiarism Yes Review by Single anonymous peer review Peer reviewer comments 3 Editor who approved publication: Dr Roger Pinder Tieru Zhang,1 Hao Du,2 Shun Wang3 1Graduate School, Heilongjiang University of Chinese Medicine,...
LincRNA-p21: a double-edged sword in ethanol-induced liver damage and | IJN
Back to Journals » International Journal of Nanomedicine » Volume 21 Authors Wang S, Nie ZC, Liu Y, Zhang ZY, Feng YM, Wang C, Jiang J Received 2 December 2025 Accepted for publication 4 February 2026 Published 14 February 2026 Volume 2026:21 Pages 1—16 DOI https://doi.org/10.2147/IJN.S577455 Checked for plagiarism Yes Review by Single anonymous peer review Peer reviewer comments 2 Editor who approved publication: Professor Eng San Thian Shun Wang,1 Zhao-Chao Nie,1 Yang Liu,2 Zhi-Yue Zhang,2...
Durable acidic water oxidation ruthenium based electrocatalyst by fluorination induced symmetry breaking - Nature Communications
Abstract Ru–based materials exhibit high electrocatalytic activity for the acidic oxygen evolution reaction, but they are prone to transform into soluble RuO4 species via traditional lattice oxygen mechanism at high oxidation potentials, resulting in rapid inactivation.
Neoadjuvant ctDNA-MRD monitoring uncovers occult progression despite radiologic response in locally advanced hypopharyngeal carcinoma: a case report
Abstract Background: The assessment of treatment response during neoadjuvant therapy for head and neck squamous cell carcinoma (HNSCC) relies largely on radiographic and endoscopic evaluations, which may fail to detect minimal residual disease (MRD). Circulating tumor DNA (ctDNA)-based MRD monitoring has emerged as a sensitive biomarker capable of revealing molecular disease activity that is not captured by imaging. Evidence supporting its use in the neoadjuvant setting of HNSCC remains limited.
A Balanced Partitioning Method for Big Graphs via Coarsen‐Partition‐Refining Steps With Preserving Atomic Subgraphs
Conflicts of Interest The authors declare no conflicts of interest. References 1, , , et al., “More Recent Advances in (Hyper) Graph Partitioning,” ACM Computing Surveys 55, no. 12 (2023): 1–38. 2, , and , “An Investigation of Big Graph Partitioning Methods for Distribution of Graphs in Vertex-Centric Systems,” Distributed and Parallel Databases 38, no. 1 (2020): 1–29. 3, , , , and , “Recent Advances in Graph Partitioning,” Lecture Notes in Computer Science 24 (2016): 117–158.
The effects of acute carbohydrate supplementation on inflammatory cytokines in individuals performing different exercise intensities: a systematic review and meta-analysis
Abstract Objective: This study aims to conduct a systematic review and meta-analysis to examine the effects of carbohydrate supplementation on inflammatory cytokines under different exercise intensities, and to explore the interaction between carbohydrate types and exercise intensity in the regulation of inflammation. Methods: A systematic search of PubMed, EBSCOhost, Cochrane, Web of Science and CNKI.
A Systematic Computational Framework for Practical Identifiability Analysis in Mathematical Models Arising from Biology
1 Introduction In systems biology, mathematical modeling is a widely used and powerful tool for analyzing biological processes across multiple scales.
Closed‐Form Hypoplastic Solutions for Normally Consolidated Soil in Element Tests
1 Introduction Within the framework of continuum mechanics, a constitutive model serves as a crucial link between stress and strain [1, 2]. While elastoplastic theory offers advanced models emphasizing features like strain softening, anisotropic hardening, and endochronic intrinsic time [3, 4], their enhanced performance often comes at the cost of simplicity.
Engineering 4‐Connecting 3D Covalent Organic Frameworks with Oriented Li+ Channels for High‐Performance Solid‐State Electrolyte in Lithium Metal Battery
Conflict of Interest The authors declare no conflict of interest. Supporting Information Filename Description smll202502407-sup-0001-SuppMat.docx11.2 MB Supporting Information smll202502407-sup-0002-MovieS1.mp411.1 MB Supplemental Movie 1 References 1, , , , , , , , , , , , , , Nat. Commun. 2024, 15, 10045. 2, , , , , , , Adv. Mater. 2023, 35, 2206625. 3, , , , , , , , , , , Nat. Commun. 2024, 15, 10015. 4, , , , Nat. Rev. Mater. 2020, 5, 229. 5, , , , , , , , , , , , , , Nat. Commun. 2024, 15, 4454.
Improving the fast-charging capability of NbWO-based Li-ion batteries - Nature Communications
Abstract The discovery of Nb-W-O materials years ago marks the milestone of charging a lithium-ion battery in minutes. Nevertheless, for many applications, charging lithium-ion battery within one minute is urgently demanded, the bottleneck of which largely lies in the lack of fundamental understanding of Li+ storage mechanisms in these materials.
Parameter identification of the PV systems based on an adapted version of human evolutionary optimizer - Scientific Reports
Abstract Modelling the circuit model parameters of photovoltaic (PV) cells and modules is one of the significant encounters in the field of solar energy. Lately, with the advance of the application of optimization algorithms, approximating the PV module parameters can be changed into an optimization problem. This research offers an optimization pipeline for the optimal collection of the parameters in the PV systems.
Compact Multi-Channel Long-Wave Wideband Direction-Finding System and Direction-Finding Analysis for Different Modulation Signals
All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.
Integrating multiscale mathematical modeling and multidimensional data reveals the effects of epigenetic instability on acquired drug resistance in cancer
Loading metrics Open Access Peer-reviewed Research Article ? This is an uncorrected proof. Citation: Wang S, Lei J, Zou X, Jin S (2025) Integrating multiscale mathematical modeling and multidimensional data reveals the effects of epigenetic instability on acquired drug resistance in cancer. PLoS Comput Biol 21(2): e1012815.
Mechanistic Insights into CYP199A4-Catalyzed α-Hydroxyketone Formation and Hydrogen Bond-Assisted C-C Bond Cleavage Catalyzed by the CYP199A4 F182L Mutant
All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.
Numerical Simulation and Optimization Study on the Flow Field Characteristics of a Double-Slot Spillway
1. Introduction The spillway is a crucial component of high dam water-release structures [1,2,3,4], designed to discharge floodwaters that exceed the reservoir’s storage capacity and ensure the structural safety of the dam. Effective energy dissipation in spillway structures is a crucial factor ensuring the safe operation of hydraulic projects [5]. In steep terrain, conventional spillway designs often necessitate a broader chute cross section to accommodate large design flood discharges.
We propose and demonstrate a reconfigurable 4 × 4 multi-input multi-output (MIMO) all-optical unitary converter (OUC) based on non-uniform multimode interference (nMMI-OUC) on a lithium-niobate-on-insulator (LNOI) platform, which has the advantages of broadband operation, compactness, low loss, and fabrication-friendliness. To enhance the bandwidth, compact non-uniform multimode interference is utilized to replace uniform multimode interference, achieving the same cross talk and larger bandwidth.
Ru@MnO2 core@shell nanowires as bifunctional electrocatalyst for efficient solar-driven seawater splitting
Ru@MnO2 core@shell nanowires as bifunctional electrocatalyst for efficient solar-driven seawater splitting Seawater electrolysis technology for hydrogen production has attracted worldwide attention due to the abundant seawater resources. Herein, we proposed a core–shell Ru@MnO2 nanowires (NWs) with α/β–MnO2 NWs as core and amorphous Ru as shell, in which Ru@α–MnO2 NWs exhibited lower overpotential and better stability.
An interpretable disruption predictor on EAST using improved XGBoost and SHAP
ACCEPTED MANUSCRIPT • The following article is Open access An interpretable disruption predictor on EAST using improved XGBoost and SHAP Dongmei Liu, Xinli Zhu, Yusong Jiang, Shun Wang, Shuangbao Shu, Biao Shen, Bihao Guo and liangcheng Liu Accepted Manuscript online 11 July 2025 • © 2025 The Author(s).
Altered neuroplasticity in epilepsy is associated with neuroinflammati
Back to Journals » International Journal of Nanomedicine » Volume 20 Authors Wang S , Zhang H, Li R, Liu Z, Xiang D Received 27 December 2024 Accepted for publication 22 May 2025 Published 4 June 2025 Volume 2025:20 Pages 7185—7197 DOI https://doi.org/10.2147/IJN.S514559 Checked for plagiarism Yes Review by Single anonymous peer review Peer reviewer comments 2 Editor who approved publication: Prof.
Mechanical Properties of a Stability‐Enhancing Honeycomb with Double‐Platform Stresses and Variable Stiffness
Conflict of Interest The authors declare no conflict of interest. References 1 , , , , , Int. J. Extreme Manuf. 2023, 5, 042003. 2 , , , , , Thin-Walled Struct. 2024, 198, 111757. 3 , , , , Thin-Walled Struct. 2022, 170, 108530. 4 , , Eng. Struct. 2022, 267, 114682. 5 , , , , Compos. Struct. 2021, 277, 114605. 6 , , , Int. J. Mech. Sci. 2023, 242, 108015. 7 , , , Int. J. Mech. Sci. 2024, 261, 108664. 8 , , , Mater. Today: Proc. 2022, 54, 690. 9 , , , Compos. Struct. 2021, 257, 113159. 10 , , J. Manuf. Syst. 2015, 37, 375.
The Formation of Rice Tillers and Factors Influencing It
All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.
Biomechanical Analysis of Limb Coordination in Front-Crawl Among Elite S10 and S12 Para Swimmers: Implications for Performance Optimization
All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.
Author Correction: Community assessment of methods to deconvolve cellular composition from bulk gene expression - Nature Communications
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Correction to: Nature Communications https://doi.org/10.1038/s41467-024-50618-0, published online 27 August 2024 The original version of this Article omitted from the Tumor Deconvolution DREAM Challenge consortium the members Aashi Jain, Shreya Mishra, and Vibhor Kumar from Department of Computer Science, Indraprastha Institute of Information Technology, Okhla Ph-3, New Delhi, India, Jiajie Peng and Lu Han from School of Computer Science, Northwestern Polytechnical University, Xi’an, Shaanxi,...
By Brian White, Aaron M. Newman, Joshua J. Waterfall, Florent Petitprez, Yating Lin, Rongshan Yu, Gianni Monaco, Verena Chung, Jineta Banerjee, Daniel Derrick, Xu Xiao, Shun Wang, Wenxian Yang, Benjamin Lang, Francesca Caruso, Michele Ceccarelli, Holden T Maecker, Caroline Duault, Julio Saez-Rodriguez, Laura M. Heiser
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Nature
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Hepatic angiosarcoma with eosinophilia：A case report and literature | IJWH
Back to Journals » International Journal of Women's Health » Volume 17 Authors Chen M, Chen X, Wang S, Lei D, Peng C Received 6 November 2024 Accepted for publication 8 March 2025 Published 14 March 2025 Volume 2025:17 Pages 785—791 DOI https://doi.org/10.2147/IJWH.S505065 Checked for plagiarism Yes Review by Single anonymous peer review Peer reviewer comments 2 Editor who approved publication: Professor Elie Al-Chaer Meiqin Chen,1 Xiguo Chen,2 Shun Wang,1 Dan Lei,1 Chunxian Peng1 1Department...
Development of a Real-Time NOx Prediction Soft Sensor Algorithm for Power Plants Based on a Hybrid Boost Integration Model
1. Introduction Nitrogen oxides, generally known as NOxs, are some of the most important hazardous air pollutants from industry [1,2]. In China, the NOx emission in the waste gas of industrial sources was about 8.957 million tons in 2022 [3]. When emitted into the atmosphere, NOx undergoes a series of photochemical reactions with volatile organic compounds under the UV light of sun radiation to generate irritating photochemical smog [4,5]. NOx also reacts with O2 and H2O to form acid rain [6].
In‐Plane Energy Absorption Properties of Novel Curved‐Ligaments Auxetic Cellular Structures with Dual‐Platform Performance
Conflict of Interest The authors declare no conflict of interest. References 1 , , , , , Mater. Des. 2016, 110, 705. 2 , , , Compos., B Eng. 2019, 164, 280. 3 , , , , Thin-Walled Struct. 2018, 133, 180. 4 , , , , , Compos. Struct. 2018, 187, 429. 5 , , , Thin-Walled Struct. 2020, 147, 106494. 6 , , , , , Compos., B Eng. 2017, 110, 72. 7 , , , , Mater. Des. 2017, 133, 154. 8 , , , , , Int. J. Mech. Sci. 2020, 168, 105307. 9 , , , , Mech. Sci. 2022, 216, 106986. 10 , Compos., B Eng. 2019, 166, 731. 11 , , Int. J. Mech. Sci.
2LiBH4-MgH2 System Catalytically Modified with a 2D TiNb2O7 Nanoflake for High-Capacity, Fast-Response, and Long-Life Hydrogen Energy Storage
Energy, Environmental, and Catalysis ApplicationsSeptember 2, 2024 Zhenglong Li Institute of Science and Technology for New Energy, Xi’an Technological University, Xi’an 710021, PR China Kaicheng Xian State Key Laboratory of Silicon and Advanced Semiconductor Materials, School of Materials Science and Engineering, Zhejiang University, Hangzhou 310027, PR China * Mingxia Gao State Key Laboratory of Silicon and Advanced Semiconductor Materials, School of Materials Science and Engineering,...
Superior-Performance Lithium-Sulfur Battery: Face-Centered-Cubic-Structure High-entropy Alloy Improves the Bidirectional Catalytic Conversion of Polysulfide/Sulfide
Superior-Performance Lithium-Sulfur Battery: Face-Centered-Cubic-Structure High-entropy Alloy Improves the Bidirectional Catalytic Conversion of Polysulfide/Sulfide Herein, we demonstrate a face-centered cubic-structure cobalt-nickel-copper-manganese-molybdenum high-entropy alloy (CoCuMnMoNi-HEA) anchored on a reduced graphene oxide (rGO) substrate as a separator intercalation layer (CoCuMnMoNi-HEA@rGO) for lithium-sulfur batteries.
Community assessment of methods to deconvolve cellular composition from bulk gene expression - Nature Communications
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Abstract We evaluate deconvolution methods, which infer levels of immune infiltration from bulk expression of tumor samples, through a community-wide DREAM Challenge. We assess six published and 22 community-contributed methods using in vitro and in silico transcriptional profiles of admixed cancer and healthy immune cells. Several published methods predict most cell types well, though they either were not trained to evaluate all functional CD8+ T cell states or do so with low accuracy.
By Brian White, Aaron M. Newman, Joshua J. Waterfall, Florent Petitprez, Yating Lin, Rongshan Yu, Gianni Monaco, Jineta Banerjee, Daniel Derrick, Xu Xiao, Shun Wang, Wenxian Yang, Benjamin Lang, Francesca Caruso, Michele Ceccarelli, Holden T Maecker, Julio Saez-Rodriguez, Laura M. Heiser, Verena Chung, Caroline Duault
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Nature
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Multiagent trajectory prediction with global‐local scene‐enhanced social interaction graph network
CONFLICT OF INTEREST STATEMENT The authors declare no potential conflict of interests. REFERENCES 1, , . GameFormer: Game-theoretic modeling and learning of transformer-based interactive prediction and planning for autonomous driving. arXiv preprint, arXiv:230305760. 2023. 2, , , , , , et al. Multimodal trajectory predictions for autonomous driving using deep convolutional networks. ICRA. Montreal, Canada: IEEE; 2019. p. 2090–2096. 3, , .
Dual‐step Redox Engineering of Two‐Dimensional CoNi‐Alloy Embedded B, N‐Doped Carbon Layers towards Tunable Electromagnetic Wave Absorption and Light‐Weight Infrared Stealth Heat Insulation Devices
Supporting Information Filename Description adma202403322-sup-0001-SuppMat.docx9.8 MB Supporting Information adma202403322-sup-0002-VideoS1.mp42.7 MB Supplemental Video 1 adma202403322-sup-0003-VideoS2.mp42.8 MB Supplemental Video 2 adma202403322-sup-0004-VideoS3.mp42.2 MB Supplemental Video 3 adma202403322-sup-0005-VideoS4.mp42.6 MB Supplemental Video 4 adma202403322-sup-0006-VideoS5.mp42.9 MB Supplemental Video 5
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