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Shunying Li on Muck Rack

Shunying Li

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Articles

Everolimus destabilizes thymidylate synthase via suppressing its O-GlcNAcylation and sensitizes HER2-negative breast cancer to fluorouracil

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By Xiao-Ting Jiang, Shaoyi Wang, Linghan Wang, Zijie Cai, Jingru Wang, Mengdi Zhu, Nianqiu Liu, Wang Yang, Yujie Liu, Liang Jin, Yudong Li, Shunying Li, Qianfeng Shi, Jinna Lin, Keyang Qian, Qi Wang, Xin Yang, Yingyan Chen, Yinxia Wu, Qiang Liu, Huipei Gan, Zhuangqiu Yang
| Nature Verified
Abstract 5-Fluorouracil (5-FU) and its prodrugs are widely used drugs for chemotherapy in various cancers. However, their effectiveness in breast cancer is limited. mTORC1 pathway, as a known mediator of therapy resistance in breast cancer, presents a compelling target for combination approaches.
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