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Yingyan Chen

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Articles

Everolimus destabilizes thymidylate synthase via suppressing its O-GlcNAcylation and sensitizes HER2-negative breast cancer to fluorouracil

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By Xiao-Ting Jiang, Shaoyi Wang, Linghan Wang, Zijie Cai, Jingru Wang, Mengdi Zhu, Nianqiu Liu, Wang Yang, Yujie Liu, Liang Jin, Yudong Li, Shunying Li, Qianfeng Shi, Jinna Lin, Keyang Qian, Qi Wang, Xin Yang, Yingyan Chen, Yinxia Wu, Qiang Liu, Huipei Gan, Zhuangqiu Yang
| Nature Verified
Abstract 5-Fluorouracil (5-FU) and its prodrugs are widely used drugs for chemotherapy in various cancers. However, their effectiveness in breast cancer is limited. mTORC1 pathway, as a known mediator of therapy resistance in breast cancer, presents a compelling target for combination approaches.
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“The unseen struggle” - Nurses' perspectives on challenges to quality of death in rural Chinese cancer patients: A qualitative study

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By Frances Lin, Yingyan Chen, Mi Hu, Michael Phillips
| ScienceDirect Verified
Section snippets What is already known • Most studies on the quality of death and palliative care for cancer patients in China focus on urban settings, leaving rural populations understudied. • Patients with advanced cancer in rural China may face distinct challenges, including low health literacy, culturally influenced health beliefs, limited cancer knowledge, and restricted access to healthcare services.
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Effectiveness of abdominal massage on chronic constipation in adults: A systematic review and meta-analysis

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By Jin Yang, Qi Lu, Frances Lin, Yingyan Chen
| ScienceDirect Verified
Section snippets What is already known • Chronic constipation is a prevalent and distressing symptom. • There are different types of abdominal massage techniques, which may be safe and noninvasive ways to relieve constipation symptoms. • The literature does not provide a clear understanding of the effectiveness of abdominal massage in constipation symptoms, limiting its' clinical application.
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