Is this you? As a journalist, you can create a free Muck Rack account to customize your profile, list your contact preferences, and upload a portfolio of your best work.
Claim your profile
Articles by Si Sun
PRC2 governs HR proficiency and chemosensitivity in ovarian cancer via SQSTM1-mediated chromatin ubiquitination
Abstract Platinum and poly (ADP-ribose) polymerase (PARP) inhibitors are cornerstone therapies for ovarian cancer (OC), and their efficacy relies on homologous recombination deficiency (HRD), leaving more than 50% of HRD-negative OC patients with limited treatment options. This study investigated the epigenetic regulator, Polycomb Repressive Complex 2 (PRC2), as both a potential modulator of homologous recombination (HR) status and a candidate therapeutic target in ovarian cancer.
Genetically modulating the RNA-binding protein Regnase-1 reveals its critical role in regulatory T cell homeostasis and function in vivo
Abstract Regnase-1 is a CCCH-type RNA-binding protein that constantly degrades mRNA species via its ribonuclease domain to maintain immune quiescence. But how and by what mechanisms Regnase-1 regulates Foxp3+ Tregs remains poorly studied. Here, we generated a conditional knock-in strain in which a degradation-resistant Regnase-1 mutant (R111A) was selectively expressed in Foxp3+ Tregs as a transgene (Foxp3YFP-CreLSL-R111Afl/fl) to investigate the roles of Regnase-1 in Tregs.
A Phase II study of SHR-A1921, a TROP2-targeted antibody–drug conjugate, in patients with recurrent or metastatic salivary gland carcinoma
Abstract Advanced salivary gland carcinoma (SGC) lacking both human epidermal growth factor receptor 2 (HER2) and androgen receptor (AR) expression has limited treatment options. In this single-center, phase II trial, patients with recurrent/metastatic HER2-negative/AR-negative SGC received SHR-A1921, a TROP-2-directed antibody-drug conjugate, every 3 weeks until disease progression or unacceptable toxicity.
Built-in electric field activates endogenous redox couple for self-sustained Fenton-like reaction
Abstract Heterogeneous catalyst systems hold significant potential for advanced water treatment, yet achieving sustainable catalytic processes capable of continuously generating reactive species remains a substantial challenge. In this work, we develop an integrated oxidation-reduction system that synergistically couples peracetic acid (PAA) with H2O2 under the guidance of an interfacial built-in electric field (BEF).
Liquid-liquid phase separation of CBX2 regulates lipid raft-mediated extracellular vesicle biogenesis to facilitate ovarian carcinoma metastasis
Abstract Extracellular vesicles (EVs) play a vital role in ovarian carcinoma (OvCa) metastasis, yet the mechanisms regulating EV biogenesis remain unclear. Here, we identify CBX2 as a key driver of omental metastasis, with elevated expression in metastatic lesions and association with poor prognosis.
CBX2 phase-separation contributes to homologous recombination repair and drug resistance in ovarian cancer
Abstract Drug resistance jeopardizes the prognosis of high-grade serous ovarian carcinoma (HGSOC) patients via DNA damage repair-coupled mechanism. The role of biomolecular phase separation in DNA damage repair has loomed. Here we find that CBX2 condensates are associated with drug resistance and contribute to DNA double-strand break (DSB) repair in HGSOC. Specifically, CBX2 condensates facilitate the recruitment of key DSB repair factors PARP1, 53BP1, and BRCA1 to chromatin.
Associations of triglyceride-glucose-related indices and cardiovascular health with retinal arteriosclerosis: a cross-sectional study
Abstract Objective: Retinal arteriosclerosis (RA) is a visible marker of early microvascular injury largely driven by cardiovascular risk factors. Insulin resistance, represented by the triglyceride-glucose (TyG) related indices, may serve as a key mediator linking cardiovascular health (CVH) to RA.
DDX41 facilitates PD-L1-mediated immune escape in OSCC via the phase separation and activation STING pathway - npj Precision Oncology
Abstract DEAD-box helicase 41 (DDX41) functions as an oncogene in multiple cancers and is associated with immune response. However, the specific role of DDX41 in oral squamous cell carcinoma (OSCC) has not yet been elucidated. The data from public databases show that DDX41 protein expression is elevated in OSCC tumor tissues and linked to poor prognosis. Loss of DDX41 in OSCC cells leads to an inhibition in the ability of tumor proliferation and invasion.
Atomically Precise Clusterzymes: A Programmable Optoelectronic Platform for Neuroscience
1 Introduction Enzymes, the quintessential biocatalysts, orchestrate nearly all biochemical processes in living systems with extraordinary efficiency and stereochemical precision. From oxidoreductases that manage cellular redox states to hydrolases that cleave biomolecular bonds, these specialized proteins are indispensable for sustaining life.
Systematic Comparison and Distribution Patterns of Bioactive Metabolites in Different Polarity Fractions of Gentiana scabra Bunge Ethanol‐Water Extract
Conflicts of Interest The authors declare no conflicts of interest. Data Availability Statement All data generated or analyzed during this study are included in this published article (and its ). Supporting Information Filename Description bmc70378-sup-0001-Table_S1.docxWord 2007 document , 18.4 KB Table S1: Complete LC–MS spectral parameters of identified compounds. bmc70378-sup-0001-Table_S2.xlsxExcel 2007 spreadsheet , 16.9 KB Table S2: Supporting information. References , , and . 2007.
Metabolic Enzyme‐Inspired Molecular Clusters for Advanced Type 2 Diabetic Complications by Alleviating Immunosuppression
Opens in a new window Opens an external website Opens an external website in a new window To improve your experience, we (and our partners) store and/or access information on your terminal (cookie or equivalent) with your consent for all our websites and applications, on your connected terminals.
The cyclin-dependent kinase inhibitor p27 facilitates chemosensitivity by promoting ferroptosis in epithelial ovarian cancer
Keywords Ovarian carcinoma chemoresistance Iron-dependent cell death CDKN1B cytochrome b-245 heavy chain Introduction Epithelial ovarian cancer (EOC) is the second most lethal gynecologic malignancy and ranks as the eighth leading cause of cancer-related deaths among women globally (1). The standard treatment for EOC patients consists of primary debulking surgery followed by platinum-based chemotherapy (2).
LEF1 confers resistance to DNA-damaging chemotherapies through upregulation of PARP1 and NUMA1 in ovarian cancer - Oncogene
Abstract Resistance to platinum-based drugs and PARP inhibitors (PARPi) is the leading cause of treatment failure in epithelial ovarian cancer (EOC). This study aimed to identify resistance mechanisms shared by both. Using bioinformatic analyses, EOC tissues, primary tumor cells and organoids, and chemoresistant cell lines, we identified lymphoid enhancer-binding factor 1 (LEF1) as a candidate, whose expression was increased in both platinum-resistant and PARPi-resistant tumors.
EZH2 activates CHK1 signaling to promote ovarian cancer chemoresistance by maintaining the properties of cancer stem cells
Department of Obstetrics and Gynecology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China. #These authors contributed equally to this article. Received 2020-5-12; Accepted 2020-10-18; Published 2021-1-1 Citation: Wen Y, Hou Y, Yi X, Sun S, Guo J, He X, Li T, Cai J, Wang Z. EZH2 activates CHK1 signaling to promote ovarian cancer chemoresistance by maintaining the properties of cancer stem cells. Theranostics 2021; 11(4):1795-1813.
Crown Castle to Sell Fiber Segment to Zayo and Small Cells Business to EQT for a Combined $8.5 Billion
The Firm is representing the Zayo Group (“Zayo”), a leading communications infrastructure provider backed by DigitalBridge and EQT, in connection with the announced acquisition of Crown Castle’s Fiber Solutions business, valued at approximately $4.25 billion.
Apex1 safeguards genomic stability to ensure a cytopathic T cell fate in autoimmune disease models
ResearchAutoimmunityImmunology Open Access | 10.1172/JCI183671 J Clin Invest. https://doi.org/10.1172/JCI183671. Copyright © 2024, Xiao et al. This work is licensed under the Creative Commons Attribution 4.0 International License. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. View PDF Abstract T cells have a remarkable capacity to clonally expand, a process that is intricately linked to their effector activities.
Association Between Low Triglyceride-Glucose Index and Mortality in Ac
Back to Journals » Journal of Multidisciplinary Healthcare » Volume 18 Authors Zhang Q , Xu Y, Sun S, Ding X, Wang G, Jiang S, Zheng J, Gao P, Lin J, Wu Y Received 31 December 2024 Accepted for publication 14 March 2025 Published 20 March 2025 Volume 2025:18 Pages 1711—1719 DOI https://doi.org/10.2147/JMDH.S513948 Checked for plagiarism Yes Review by Single anonymous peer review Peer reviewer comments 2 Editor who approved publication: Professor Charles Victor Pollack Qingqing Zhang,1,2,*...
Experimental Investigation on Heat Transfer Enhancement of Phase Change Materials by Fractal Fins
All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.
Cisplatin induces acute kidney injury by downregulating miR‐30e‐5p that targets Galnt3 to activate the AMPK signaling pathway
CONFLICT OF INTEREST STATEMENT The authors declare that they have no competing interests. Supporting Information Filename Description tox24054-sup-0001-Excel 1.xlsxExcel 2007 spreadsheet , 62 KB Data S1. Excel 1. tox24054-sup-0002-Excel 2.xlsxExcel 2007 spreadsheet , 290.2 KB Data S2. Excel 2. tox24054-sup-0003-Supinfo.docxWord 2007 document , 12.5 MB Data S3. Supporting Information. REFERENCES 1, , , et al. World incidence of AKI: a meta-analysis. Clin J Am Soc Nephrol. 2013; 8(9): 1482-1493.
An anti‐abrasion sandwich structured membrane for highly efficient oil/water separation
CONFLICT OF INTEREST STATEMENT The authors declare no conflict of interest. Supporting Information Filename Description pat6171-sup-0001-Figures.docxWord 2007 document , 228.9 KB FIGURE S1. The contact angle of (A) unmodified mesh and (B) PAM modified mesh. FIGURE S2. The contact angle of PAM modified mesh after abrasion (A) with and (B) without cotton fabric protection. pat6171-sup-0002-Movie_1.m4vvideo/m4v, 3.6 MB MOVIE 1. Supporting Information.
Optical system design of double-sided telecentric microscope with high numerical aperture and long working distance
Save citation to file Format: Add to My Bibliography Your saved search Name of saved search: Search terms: Frequency: Which day? Which day? Report format: Send at most: Send even when there aren't any new results Optional text in email: Create a file for external citation management software
A Trisulfide Bond Containing Biodegradable Polymer Delivering Pt(IV) Prodrugs to Deplete Glutathione and Donate H2S to Boost Chemotherapy and Antitumor Immunity
Download Hi-Res ImageDownload to MS-PowerPointCite This:ACS Nano 2024, XXXX, XXX Terms & Conditions Most electronic Supporting Information files are available without a subscription to ACS Web Editions. Such files may be downloaded by article for research use (if there is a public use license linked to the relevant article, that license may permit other uses).
An Efficient Improved Harris Hawks Optimizer and Its Application to Form Deviation-Zone Evaluation
Abstract : Evaluation of the deviation zone based on discrete measured points is crucial for quality control in manufacturing and metrology. However, deviation-zone evaluation is a highly nonlinear problem that is difficult to solve using traditional numerical optimization methods. Swarm intelligence has many advantages in solving this problem: it produces gradient-free, high-quality solutions and is characterized by its ease of implementation.
The attitudes about life-sustaining treatment among cardiac surgery ICU patients and their families
Skip to main page content Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation Save citation to file Format: Add to My Bibliography Your saved search Name of saved search: Search terms: Frequency: Which day? Which day? Report format: Send at most: Send even when there aren't any new results Optional text in email: Create a file for external citation management software doi: 10.3389/fsurg.2023.1079337.
Robust and Fast Normal Mollification via Consistent Neighborhood Reconstruction for Unorganized Point Clouds
This is an early access version, the complete PDF, HTML, and XML versions will be available soon.
Prognostic analysis of antibody typing and treatment for antiphospholipid syndrome‐related recurrent spontaneous abortion
Abstract Objective To determine the efficacy of antibody typing and treatment on live birth rate in Chinese patients with antiphospholipid syndrome (APS)-related recurrent spontaneous abortion (RSA). Methods A retrospective study analyzed 4542 Chinese patients who experienced spontaneous abortion, of whom 314 had APS (272 primary and 42 secondary). Type of antibodies was tested. Anticoagulant and anti-inflammatory treatments were adopted according to the titer and type of antibodies.
Show More
loading
Actions
Is this you?
As a journalist, you can create a free Muck Rack account to customize your profile, list your contact preferences, and upload a portfolio of your best work.Get in touch with Si
Contact Si, search articles and posts on X, monitor coverage, and track replies from one place.
Learn more about Muck Rack