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Articles by Siling Du
Priming of CD8 + T cells by peripheral dendritic cells exacerbates tau-mediated neurodegeneration
Abstract Alzheimer’s disease and primary tauopathies are marked by changes in adaptive immunity, with increased brain CD8+ T cells correlating with tau pathology severity. However, how peripheral T cells get primed to enter the brain and contribute to tau-mediated neurodegeneration remains unclear. In different disease conditions, conventional type 1 dendritic cells (cDC1s) cross-present antigens to prime CD8+ T cells into effector cells.
ID2 secures cDC1 specification by antagonizing E proteins at a pleiotropic Zeb2 enhancer
Abstract The transcriptional regulator ID2 is required for type 1 classical dendritic cell (cDC1) specification, yet the mechanism has remained obscure. We previously identified the Zeb2 −165-kb enhancer as key to normal hematopoiesis, controlled by competing CEBP and NFIL3 inputs during myeloid dendritic cell divergence.
Functional role of skull lymphoid structures in CNS immunosurveillance
Abstract Accumulating evidence demonstrates that the central nervous system (CNS) is not disconnected from the peripheral immune system; however, precisely how the adaptive immune system surveils the CNS remains a critical question. Recent findings reveal that channels between the skull and the dura mater facilitate the exchange of cerebrospinal fluid and immune cells between the CNS and skull bone marrow of mice under both homeostatic and disease conditions1,2,3,4,5,6.
Diversity and Immune Dynamics of Choroid Plexus Macrophages Are Shaped by Distinct Developmental Origins
Publication Date 3-1-2026 Journal Nature Neuroscience DOI 10.1038/s41593-025-02158-z PubMedCentral® Posted Date 7-21-2026 PubMedCentral® Full Text Version Author MSS Abstract The choroid plexus forms a key barrier and signaling interface between the brain and peripheral circulation, yet its immune landscape remains incompletely understood.
Brain perivascular macrophages regulate endothelial cell function via a cMAF-dependent transcriptional program in mouse and human
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Keywords perivascular macrophages microglia cMAF arteries immune-vascular axis cerebrospinal fluid cerebral blood flow IGF1 APOE4 Alzheimer's disease Introduction Brain macrophages are implicated in maintaining CNS homeostasis and immune defense.
By Simone Brioschi, Julia A. Belk, Steffen E. Storck, Yue Wu, Zhuoying Wang, Ziang Feng, Lynn van Olst, Josie L. Emery, Raki Sudan, Junjie Wu, Siling Du, Marco Genua, Federica La Terza, ALEX EDWARDS, Khai Nguyen, Jessie Sanford, Daniel Lee, Mattia Bugatti, Yun Chen, Zuoxu Wang, Silvia Penati, Patrick Rodrigues, Alina Ulezko Antonova, Igor G. Smirnov, Susan Gilfillan, Carmen M. Halabi, Jennifer Ponce, Jun Yan, Howard Chang, Gwendalyn J. Randolph, William Vermi, Marina Cella, Michael Meers, Renato Ostuni, David Gate, AiVi Nguyen, Carlos Cruchaga, Song Hu, Jonathan Kipnis, Marco Colonna, Arnold J. Federico, Hui Qi Loo
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Cell Press
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Brain-Engrafted Monocyte-Derived Macrophages From Blood and Skull-Bone Marrow Exhibit Distinct Properties
10.1016/j.neuron.2026.01.032 macrophage ontogeny, microglia, monocyte, monocyte-derived macrophages, skull-bone marrow yes Du, Siling; Ou, Feiya; Drieu, Antoine; et al., "Brain-Engrafted Monocyte-Derived Macrophages From Blood and Skull-Bone Marrow Exhibit Distinct Properties" (2026). The Brown Foundation: Institute of Molecular Medicine. 43. https://digitalcommons.library.tmc.edu/molecular_med/43
Brain-engrafted monocyte-derived macrophages from blood and skull-bone marrow exhibit distinct properties
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Keywords microglia monocyte monocyte-derived macrophages skull-bone marrow macrophage ontogeny Introduction Microglia, the major immune cell type situated in the central nervous system (CNS) parenchyma, account for 5%–20% of total glial cells in the CNS.1,2 During CNS development, microglia play important roles in various processes such as neurogenesis, synaptic pruning, and the establishment and rewiring of neural circuits.3,4,5,6,7 Fate-mapping studies demonstrated that microglia originate...
By Siling Du, Feiya Ou, Antoine Drieu, Eric Xu, Yumeng Cheng, Steffen E. Storck, Tornike Mamuladze, Jay J Cao, Nora Abduljawad, Bishan Bhattarai, Justin Rustenhoven, Niall Mortimer, Simone Brioschi, Khai Nguyen, Patrick Rodrigues, Igor G. Smirnov, Daniel Gibson, J. Michael White, Wandy Beatty, David G. DeNardo, Qingyun Li, Michael Meers, Claudia Han, Na Sun, Florent Ginhoux, Marina Cella, Marco Colonna, Jonathan Kipnis
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Cell Press
Verified
Publisher Correction: Diversity and immune dynamics of choroid plexus macrophages are shaped by distinct developmental origins - Nature Neuroscience
Correction to: Nature Neuroscience https://doi.org/10.1038/s41593-025-02158-z, published online 21 January 2026. In the version of the article initially published, scaling of some of the y axes in Fig. 5h was incorrect. The figure has now been amended in the HTML and PDF versions of the article, as shown below in Fig. 1. Fig. 1 Original and corrected Fig. 5h. About this article Du, S., Nguyen, K.M., Ulezko Antonova, A. et al.
Diversity and immune dynamics of choroid plexus macrophages are shaped by distinct developmental origins - Nature Neuroscience
Abstract The choroid plexus forms a key barrier and signaling interface between the brain and peripheral circulation, yet its immune landscape remains incompletely understood. Using single-cell transcriptomics combined with lineage and spatial tracing methods, we identified three biologically distinct populations of choroid plexus macrophages, defined by differential expression of CD163, MHCII or CD9.
State-specific enhancer landscapes govern microglial plasticity
Tamoxifen delivery For Runx1-CreERT2 and Cdh5-CreERT2 lineage tracing experiments, a mixture of 1.5mg (Z)-4-Hydroxytamoxifen (Sigma H7904-25MG) and 0.75mg progesterone (to counteract estrogen agonist effects of tamoxifen) prepared in 500uL corn oil was intraperitoneally administered to a pregnant mouse carrying E7.0 or E6.5 embryos respectively. For PAM labeling, a single 10uL dose of 10mg/mL tamoxifen solution prepared in corn oil was subcutaneously injected into each P4 pup.
Transcription factor Maf promotes expression of repressor Zeb2 to drive microglia development in primitive hematopoiesis
Keywords tissue-resident macrophages microglia transcriptional regulation enhancer zinc finger E-box-binding homeobox 2 Zeb2 musculoaponeurotic fibrosarcoma oncogene homolog Maf Get full text access Log in, subscribe or purchase for full access. References 1. Ginhoux, F. ∙ Prinz, M. Origin of microglia: current concepts and past controversies Cold Spring Harb. Perspect. Biol. 2015; 7, a020537 2. Paolicelli, R.C. ∙ Sierra, A. ∙ Stevens, B. ...
Replacing microglia to treat a brain disease
Abstract Microglia, the brain’s resident macrophages, are essential for maintaining central nervous system homeostasis and orchestrating immune responses. Intrinsic microglial dysfunction can lead to a group of disorders known as primary microgliopathies.
Main text (Neuron 109, 4094–4108.e1–e5; December 15, 2021) We, the authors, recently realized in our published paper that certain images necessitate further clarification and that some were inadvertently misplaced during figure assembly. In Figure S3B, at the day 7 (D7) time point, the second (GFP, TUJ1, DAPI) and third (GFP, MAP2, DAPI) images appear to share overlapping fields of view.
Meningeal lymphatics-microglia axis regulates synaptic physiology
Keywords meningeal lymphatics E/I balance synapse microglia IL-6 aging VEGF-C VEGFR3 meningeas neuroimmunology Introduction Meningeal lymphatic vessels, located in the dura mater of the meninges, drain cerebrospinal fluid (CSF) together with its content of central nervous system (CNS)-derived waste primarily into deep cervical lymph nodes (dCLNs).1,2,3,4,5,6,7 Since the discovery of meningeal lymphatic vessels, accumulating evidence from mouse models and humans has linked their dysfunction to...
NeuroD1 induces microglial apoptosis and cannot induce microglia-to-neuron cross-lineage reprogramming
Highlights • Ectopic expression of NeuroD1 cannot induce microglia-to-neuron conversion in mice • Lentiviral leakage suggests labeling of cells other than microglia • Glia-to-neuron conversion by NeuroD1 should always be tested by rigid lineage tracing Summary recently reported NeuroD1-induced microglia-to-neuron conversion, aiming to provide an “unlimited” source to regenerate neurons.
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