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Abstract How mammals mount an effective immune response against infectious agents remains unresolved. Here we identify microbial adhesion to myeloid cells as a critical initiating event that precedes pattern recognition receptor (PRR) engagement. Using a skin infection model with pathogenic bacteria and fungi, we demonstrate that neutrophil recruitment occurs in two sequential phases.
1School of Medicine, Westlake University, Hangzhou, Zhejiang, China 2Shanghai Immune Therapy Institute, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China 3Department of Neuroscience and Biomedical Sciences, Universidad Carlos Ⅲ de Madrid, Madrid, Spain 4Department of Medicine, Section of General Pathology, University of Verona, Verona, Italy 5Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD, USA 6Institute of...
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