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Articles by Simeng Ma
Data-driven dissection of heterogeneity: a computational framework for identifying depression subtypes through multi-omics and explainable AI
Abstract Modern psychiatry is shifting from unitary diagnostic models toward identifying biologically distinct depression subtypes. Despite the potential of multi-omics and AI, the field is hindered by non-standardized pipelines and poor reproducibility.
Higher frequencies of CNV deletions in bipolar disorder among Chinese Population
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Abstract Although copy number variants (CNVs) represent well-established genetic contributors to schizophrenia (SCZ), their role in bipolar disorder (BD), especially within non-European ancestries, has been inadequately explored. We evaluated the genome-wide load of rare CNVs, encompassing deletions and duplications, in a Han Chinese sample of 3915 BD cases and 7820 ethnically matched controls.
By Yong Wu, Xiangyu Li, YaoYao Sun, Yaoyao Sun, Chuyi Zhang, Ping Sun, Li Hui, Ying Zhao, Xiaoyang Feng, Baokun Wang, Jianzhong Yang, Nan Zhang Verified, Jing Yuan, Hongyan Jiang, Yuqi Cheng, Simeng Ma, Qian Gong, Yongfeng Yang, Wenqiang Li, Luxian Lv, Dongsheng Zhou, Xingxing Li, Xiaogang Chen, Chen Zhang, Xueqin Song, Wenxin Tang, Zhongchun Liu, Yongyong Shi, Xiao Xiao, Weihua Yue, Zhiqiang Li, Ming Li, Xuyuan Yin
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Nature
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Towards precision psychiatry: Metabolomics identifies three biological subtypes of depression
Loading metrics Open Access Peer-reviewed Research Article Citation: Ma S, Nie Z, Zhang M, Mei J, Zhou E, Hu Z, et al. (2025) Towards precision psychiatry: Metabolomics identifies three biological subtypes of depression. PLOS Digit Health 4(12): e0001125.
Creating large 60Co-γ populations for functional genomics and breeding in wheat
1 Introduction Wheat is one of the oldest and most widely cultivated crops. As a vital staple food, it supplies a large share of the daily energy, fiber, and essential micronutrients required for human nutrition. Globally, the dynamics of wheat production and trade significantly influence the international political and economic landscapes.
Trans-ancestry genome-wide analyses of bipolar disorder in East Asian and European populations improve genetic discovery - Nature Neuroscience
Abstract Genome-wide association studies (GWASs) of bipolar disorder (BD) have predominantly included individuals of European (EUR) ancestry, underrepresenting non-EUR populations and limiting insight into disease mechanisms.
The relationship between vitamin D levels and depression: a genetically informed study - Nutrition Journal
At the genome-wide level, LDSC and HDL analyses revealed a significant negative genetic correlation between depression and vitD levels (LDSC: rg = −0.079, se = 0.017, p = 2.27E-06; HDL: rg = −0.082, se = 0.021, p = 7.57E-05). Bivariate MiXeR demonstrated shared genetic overlap between depression and vitD beyond genetic correlation, irrespective of the direction of variant effects.
Multi-omics insights in major depressive disorder: Dysfunction of Neurons.
The authors have declared no competing interest. This study was funded by grants from the National Natural Science Foundation of China (U21A20364) and National Key Research and Development Project of China (Grant No. 2024YFC3308400). I confirm all relevant ethical guidelines have been followed, and any necessary IRB and/or ethics committee approvals have been obtained.
Intranasal Treatment with Cannabinoid 2 Receptor Agonist HU-308 Ameliorates Cold Sensitivity in Mice with Traumatic Trigeminal Neuropathic Pain
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Characterizing Aircraft Exhaust Emissions and Impact Factors at Tianjin Binhai International Airport via Open-Path Fourier-Transform Infrared Spectrometer
All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.
The Genetic Relationships Between Post-Traumatic Stress Disorder and Its Corresponding Neural Circuit Structures
The authors have declared no competing interest. This study was funded by the National Natural Science Foundation of China (U21A20364) and the National Key R&D Program of China (2018YFC1314600) I confirm all relevant ethical guidelines have been followed, and any necessary IRB and/or ethics committee approvals have been obtained.
The Mediation Role of Sleep Disturbances between Vitamin D and Depressive Symptoms: A Cross-Sectional Study
1. Introduction Depression is a common mental disorder with high disability and suicidality [1]. The burden of depression ranks second, being only surpassed by that of cardiovascular disease. The World Health Organization Global Burden of Disease Survey estimates that by 2030, depression will rank first in the number of disability cases experienced by sufferers [2].
Screening Children’s Intellectual Disabilities with Phonetic Features, Facial Phenotype and Craniofacial Variability Index
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