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Simona Barresi on Muck Rack

Simona Barresi

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Articles

Microbial adhesion promotes Piezo1 activation to initiate innate immunity

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By Giulia Stucchi, Marco Galli, Stefano Cozzi, Anna Celant, Laura Marongiu, Giuseppe Rocca, Alessandra Polissi, Giampiero Pietrocola, Marina Vai, Iván Rabinovich Orlandi, Renato Ostuni, Angelo Lombardo, Metello Innocenti, Francesca Granucci, Francesca Colnaghi, Maria Rita Chelazzi, Alessandra Maria Martorana, Simona Barresi
| Nature Verified
Abstract How mammals mount an effective immune response against infectious agents remains unresolved. Here we identify microbial adhesion to myeloid cells as a critical initiating event that precedes pattern recognition receptor (PRR) engagement. Using a skin infection model with pathogenic bacteria and fungi, we demonstrate that neutrophil recruitment occurs in two sequential phases.
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