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Angelo Lombardo on Muck Rack

Angelo Lombardo

As seen in: Nature, Control Engineering Magazine, Ontario OUT OF DOORS Magazine
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Articles

Microbial adhesion promotes Piezo1 activation to initiate innate immunity

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By Giulia Stucchi, Marco Galli, Stefano Cozzi, Anna Celant, Laura Marongiu, Giuseppe Rocca, Alessandra Polissi, Giampiero Pietrocola, Marina Vai, Iván Rabinovich Orlandi, Renato Ostuni, Angelo Lombardo, Metello Innocenti, Francesca Granucci, Francesca Colnaghi, Maria Rita Chelazzi, Alessandra Maria Martorana, Simona Barresi
| Nature Verified
Abstract How mammals mount an effective immune response against infectious agents remains unresolved. Here we identify microbial adhesion to myeloid cells as a critical initiating event that precedes pattern recognition receptor (PRR) engagement. Using a skin infection model with pathogenic bacteria and fungi, we demonstrate that neutrophil recruitment occurs in two sequential phases.
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Selection of human hematopoietic stem cells bearing the intended functional edit by transient AND-gate reporters

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By Daniele Canarutto, Martina Fiumara, Vigneshwaran Venkatesan, Chiara Gaddoni, Kohei Shiroshita, Angelica Varesi, Luisa Albano, Gabriele Pelosi, Alfredo Silva, Claudia Firrito, Giulia Schiroli, Deborah Cipria, Stefano Beretta, Angelo Amabile, Anna Villa, Erika Zonari, Bernhard Gentner, Angelo Lombardo, Pietro Genovese, Samuele Ferrari, Luigi Naldini
| Nature Verified
Abstract Targeted genomic integration of gene-sized cassettes into hematopoietic stem and progenitor cells (HSPCs) for genetic disease treatment is constrained by the low efficiency of homology-directed repair (HDR) and frequent unintended genetic changes at the editing site.
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A potent epigenetic editor targeting human PCSK9 for durable reduction of low-density lipoprotein cholesterol levels - Nature Medicine

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By Frédéric Tremblay, Erica M Hildebrand, Angelo Lombardo, Ari E. Friedland
| Nature Verified
Abstract Epigenetic editing holds the promise of durable therapeutic effects by silencing disease-causing genes without changing the underlying DNA sequence. In this study, we designed an epigenetic editor to target human PCSK9 and thereby induce DNA methylation at this locus. A single administration of lipid nanoparticles encapsulating mRNA encoding this epigenetic editor was sufficient to drive near-complete silencing of human PCSK9 in transgenic mice.
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