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Sladjana Zagorac on Muck Rack

Sladjana Zagorac

As seen in: Nature, Gut Journal, European Journal of Cancer
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Articles

FXR–YAP signalling maintains biliary epithelial cell identity and preserves liver homeostasis

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By Zhaoshuo Wang, Sladjana Zagorac, Maria Dominguez, Jasminka Boskovic, Ajay Nair Verified, Andrea Macías-Camero, Alma Villaseñor, Robert Schwabe, Nabil Djouder, Paula Sánchez-Sánchez
| Nature Verified
Abstract Bile acids (BAs) flow through ducts lined by biliary epithelial cells (BECs), which preserve ductal integrity and liver homeostasis. Failure of this barrier causes BA accumulation in the liver parenchyma, and ultimately fibrosis. Here we show that BECs safeguard biliary barrier integrity and restrain BA-induced fibrogenesis through a cell-intrinsic mechanism involving farnesoid-X-receptor (FXR)–YAP signalling.
Open in Who Shared Issue with article?

Macrophages harness hepatocyte glutamate to boost liver regeneration - Nature

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By Sladjana Zagorac, Ruth Álvarez-Díaz
| Nature Verified
Abstract Liver regeneration after hepatectomy follows accurate coordination with the body’s specific requirements1,2,3. However, the molecular mechanisms, factors and particular hepatocyte population influencing its efficiency remain unclear. Here we report on a unique regeneration mechanism involving unconventional RPB5 prefoldin interactor 1 (URI1), which exclusively colocalizes with, binds to and activates glutamine synthase (GS) in pericentral hepatocytes.
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GATA4 and GATA6 loss-of-expression is associated with extinction of the classical programme and poor outcome in pancreatic ductal adenocarcinoma

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By Richard Jackson, Irene Felipe, Sladjana Zagorac, Christian Pilarsky
| Gut Journal Verified
Abstract Objective GATA6 is a key regulator of the classical phenotype in pancreatic ductal adenocarcinoma (PDAC). Low GATA6 expression associates with poor patient outcome. GATA4 is the second most expressed GATA factor in the pancreas. We assessed whether, and how, GATA4 contributes to PDAC phenotype and analysed the association of expression with outcome and response to chemotherapy.
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