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Smitha Rose Georgy

As seen in: Nature, Wiley Online Library, PNAS
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Articles

Non-apoptotic caspase-8 is critical for orchestrating exaggerated inflammation during severe SARS-CoV-2 infection - Nature Communications

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By Stefanie Bader, Liana Mackiewicz, Jan Schaefer, Pradeep Rajasekhar, Lachlan W. Whitehead, Smitha Rose Georgy, Rory Bowden, Kerstin Brinkmann, Marie-Liesse Asselin-Labat, Belinda Phipson, Maria C. Tanzer, Marco J Herold, André Samson, James Vince, Andreas Strasser
| Nature Verified
Abstract Inflammation and excess cytokine release are hallmarks of severe COVID-19. While programmed cell death is known to drive inflammation, its role in SARS-CoV-2 pathogenesis remains unclear. Using gene-targeted murine COVID-19 models, we here find that caspase-8 is critical for cytokine release and inflammation. Loss of caspase-8 reduces disease severity and viral load in mice, and this occurs independently of its apoptotic function.
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Morphological Investigation of Superficial Fascia Relationships With the Skin and Underlying Tissues in the Canine Hindlimb

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By Zeeshan Akbar, Smitha Rose Georgy, Christina Murray, Oday A. Al-Juhaishi
| Wiley Online Library Verified
Conflicts of Interest The authors declare no conflicts of interest. References , , , , and . 2006. “The Membranous Layer of Superficial Fascia: Evidence for Its Widespread Distribution in the Body.” Surgical and Radiologic Anatomy 28: 606–619. 2015. “Fascial Eponyms May Help Elucidate Terminological and Nomenclatural Development.” Journal of Bodywork and Movement Therapies 19: 516–525. , , , , and . 2017. “Defining the Fascial System.” Journal of Bodywork and Movement Therapies 21: 173–177.
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