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Snehlata Kumari on Muck Rack

Snehlata Kumari

As seen in: Nature, Frontiers, MDPI
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Articles

Using targeted therapy to promote a pro-inflammatory tumour microenvironment and anti-tumour immune response in high grade serous ovarian cancer

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By Zhen Zeng, Anastasia Gandini, Martina Proctor, Shivam Vora, Thomas Walsh, Sherry Wu, Jermaine I. Coward, Snehlata Kumari, Nikolas K. Haass, James Wells, Janet R. Hardy, Yaowu He, John Hooper Verified, Brian Gabrielli, Rituparna Bhatt, Nicole-Lisa Li-Ann Goh, Kaltin Ferguson, Lewis Perrin, Gwo-Yaw Ho, Jazmina L. Gonzalez Cruz
| Nature Verified
Abstract High-grade serous ovarian cancer (HGSOC) is characterized by elevated replication stress and an immunosuppressive microenvironment. A synergistic combination of checkpoint kinase 1 inhibitor (CHK1i) with low-dose hydroxyurea (LDHU) promotes a unique ATR-independent moderate replication stress response with potent anti-tumour effects.
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Innate Immune Sensors and Cell Death-Frontiers Coordinating Homeostasis, Immunity, and Inflammation in Skin

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By Snehlata Kumari, Ye Mon
| MDPI
All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.
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Dichotomous outcomes of TNFR1 and TNFR2 signaling in NK cell-mediated immune responses during inflammation - Nature Communications

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By Timothy McCulloch, Louisa Alim, Pui Yeng Lam, Elaina Coleborn, Snehlata Kumari, Marco J Herold, Christoph Wilhelm, Percy A. Knolle, Lawrence P Kane, Timothy Wells
| Nature Verified
Abstract Natural killer (NK) cell function is regulated by a balance of activating and inhibitory signals. Tumor necrosis factor (TNF) is an inflammatory cytokine ubiquitous across homeostasis and disease, yet its role in regulation of NK cells remains unclear. Here, we find upregulation of the immune checkpoint protein, T cell immunoglobulin and mucin domain 3 (Tim3), is a biomarker of TNF signaling in NK cells during Salmonella Typhimurium infection.
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