Sherry Wu

Abstract The ability to rapidly detect and evaluate potential threats is essential for survival and requires the integration of sensory information with internal state and previous experience. The lateral septum (LS)—an inhibitory structure in the limbic forebrain—is thought to integrate these higher-order cognitive signals to regulate defensive responses1,2. However, the cellular, circuit and computational mechanisms fundamental to this process remain unknown.

Abstract High-grade serous ovarian cancer (HGSOC) is characterized by elevated replication stress and an immunosuppressive microenvironment. A synergistic combination of checkpoint kinase 1 inhibitor (CHK1i) with low-dose hydroxyurea (LDHU) promotes a unique ATR-independent moderate replication stress response with potent anti-tumour effects.

Abstract Ensuring safe and effective use of artificial intelligence (AI) requires understanding and anticipating its performance on new tasks, from advanced scientific challenges to transformed workplace activities1,2,3. So far, benchmarking has guided progress in AI but has offered limited explanatory and predictive power for general-purpose AI systems4,5,6,7,8, attributed to limited transferability across specific tasks9,10,11.