Sofia Ramalho
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Articles by Sofia Ramalho
Mechanism of RACK1-dependent ZAKα activation at stalled and collided ribosomes
ArticleVolume 86, Issue 12p2341-2357.e10Open access Affiliations & Notes 1Center for Gene Expression, Department of Cellular and Molecular Medicine, University of Copenhagen, Blegdamsvej 3, 2200 Copenhagen, Denmark 2Department of Molecular Biology and Genetics, Aarhus University, Aarhus, Denmark 3Randall Centre for Cell and Molecular Biophysics, King’s College London, London SE1 1UL, UK 4Center for Integrative Genomics, University of Lausanne, 1015 Lausanne, Switzerland Article Info...
Quem tem medo da avaliação psicológica?
Nos últimos dias, muito se tem falado sobre os testes aplicados aos candidatos a magistrados. Entre manchetes, comentários nas redes e reações políticas apressadas, assistimos à divulgação, sem pudor, ética ou respeito pelos direitos de autor, de itens de testes psicológicos tratados como se fossem perguntas, ora bizarras, ora de cultura geral.
Ninguém deve ficar para trás: A urgência de cuidar da saúde mental na Europa
A psicologia tem um papel insubstituível na promoção da paz, na reconstrução social e na mitigação de traumas Há 12 minutos Por toda a Europa, há quem espere meses por um apoio que pode fazer a diferença entre viver, sobreviver ou desistir. Há quem não tenha sequer acesso. Há quem sofra em silêncio numa fila invisível de um sistema de cuidados de saúde mental que tarda a chegar. Artigo Exclusivo para subscritores Aproveite 27% desconto: subscreva por apenas 1,83€/semana!
Sanctuary for vulnerable Arctic species at the Borealis Mud Volcano - Nature Communications
Abstract Borealis is a recently discovered submerged mud volcano in the Polar North Atlantic, differing from the numerous methane seepages previously identified in the region. Here we show in situ observations from a remotely operated vehicle (ROV), capturing the release of warm (11.5 °C) Neogene sediments and methane-rich fluids from a gryphon at Borealis. The surrounding seafloor within the mud volcano features extensive carbonate deposits, indicating prolonged diffuse methane migration.
Infection-induced lysine lactylation enables herpesvirus immune evasion
Published In Science Advances Volume 11 | Issue 2 January 2025 Article versions Submission history Received: 27 August 2024 Accepted: 4 December 2024 Permissions Request permissions for this article. Acknowledgments We thank G. Laevsky and S. Wang from the Princeton University Microscopy Facility for technical support. We thank the following members of the Cristea Lab: J. Hutton for MS maintenance and support, T. Greco for input on a lactyl-IP protocol and data searching, and J. Justice and K.
Three-dimensional nonreciprocal transport in photonic topological heterostructure of arbitrary shape
Research Article PHYSICS INTRODUCTION Topological materials have garnered notable attention from researchers due to their remarkable properties, in particular the unidirectional boundary transport (1–15), which makes them highly promising for applications such as optical communications, energy transport, and quantum computing.
A spatial code for temporal information is necessary for efficient sensory learning
Research Article NEUROPHYSIOLOGY INTRODUCTION Many stimuli that drive selective behavioral decisions, such as phonemes and vocalizations (1–3), tactile textures and shapes (4, 5), or the coherent motion of a moving animal (6), are identified based on the temporal structure of the sensory inputs. This can be directly experienced when listening to time-reversed renditions of common sounds such as words that are perceptually highly distinct from the original.
Crossing exceptional points in non-Hermitian quantum systems
Research Article PHYSICS INTRODUCTION Exceptional points (EPs) are remarkable singularities occurring in non-Hermitian systems, signaling a branch point in parameter space (1–3). At an EP, two or more eigenvalues and their associated eigenstates coalesce, creating fascinating dynamics. Classes of non-Hermitian systems of particular interest are quantum systems obeying parity-time symmetry, since they can exhibit real eigenvalues despite their non-Hermiticity.
Lattice-guided growth of dense arrays of aligned transition metal dichalcogenide nanoribbons with high catalytic reactivity
Research Article MATERIALS SCIENCE INTRODUCTION Transition metal dichalcogenides (TMDs), a family of two-dimensional (2D) semiconducting materials, have been gaining interest for their potential in post-Si electronic devices to extend Moore’s law (1, 2). In particular, TMDs are expected to play an important role in future logic circuits, such as gate-all-around and nanosheet transistors, offering ultrathin 2D channels with high carrier mobility, in contrast to conventional Si electronics (3).
Eight-electron Pt/Cu superatom encapsulating three “electron-donating” hydrides
INTRODUCTION The pursuit of atomically precise metal nanoclusters relies on the knowledge that not only can their size, composition, structure, and properties be precisely tailored but also substantial atomistic insight into structure-property relationships can be gained (1, 2). Over the past few decades, various gold and silver nanoclusters have been reported, benefiting from their high stability.
Small-molecule organic ice microfibers
Published In Science Advances Volume 11 | Issue 2 January 2025 Article versions Submission history Received: 5 August 2024 Accepted: 3 December 2024 Permissions Request permissions for this article. Acknowledgments We thank L. Y. Wu in the Center of Cryo-Electron Microscopy (CCEM), Zhejiang University for the technical assistance on cryo-TEM; J. B. Zhang for the helpful discussion on the measurement of propagation loss; and K. Y. Liu for assistance on the refractive index measurement.
Plasticity of human resilience mechanisms
Research Article COGNITIVE NEUROSCIENCE INTRODUCTION Resilience is a fundamental aspect of human nature, reflecting the dynamic, plastic, and adaptive response of the brain to mitigate the damaging effects of stress. Maintenance or development of resilience mechanisms precedes recovery from trauma exposure (1–4). Resilience is not merely the opposite of vulnerability or a static trait but a dynamic process.
A DNA origami-based enzymatic cascade nanoreactor for chemodynamic cancer therapy and activation of antitumor immunity
INTRODUCTION Chemodynamic therapy (CDT), which centers on the disruption of redox homeostasis, has been rapidly emerging as an efficient and promising treatment for cancer (1–4). The higher sensitivity of cancer cells to oxidative stress than normal cells renders tumors more susceptible to reactive oxygen species (ROS)–mediated damages (5). CDT is usually triggered by Fenton-type reactions to generate highly cytotoxic ROS (6–9).
Virtual Gram staining of label-free bacteria using dark-field microscopy and deep learning
Research Article OPTICS INTRODUCTION Gram staining, one of the fundamental techniques frequently used in microbiology for the past century, enables cost-effective classification of bacterial species into Gram-positive and Gram-negative groups based on their cell wall structure (1–4). This differentiation has been crucial in many applications across diagnostics, food safety, and environmental monitoring, demonstrating its broad utility in various fields (5, 6).
Adaptive sampling-based structural prediction reveals opening of a GABAA receptor through the αβ interface
Published In Science Advances Volume 11 | Issue 2 January 2025 Article versions Submission history Received: 10 May 2024 Accepted: 4 December 2024 Permissions Request permissions for this article. Acknowledgments We thank M. Zimmerman, R. Hibbs, W. Chojnacka, and the Molecular Biophysics Stockholm environment for valuable feedback and discussion.
Non-adapted bacterial infection suppresses plant reproduction
INTRODUCTION A close connection exists between bacteria and host plants, and bacteria can evolve a variety of mechanisms to enhance their ability to infect, colonize, and interact with host plants. For nonhost plants, plants resist bacterial infection through pattern-triggered immunity (PTI), effector-triggered immunity, and hypersensitive response (1, 2). However, the specific effects of non-adapted pathogen infection on nonhost plants and the response of nonhost plants remain unclear.
A positive feedback loop between germ cells and gonads induces and maintains sexual reproduction in a cnidarian
Published In Science Advances Volume 11 | Issue 2 January 2025 Article versions Submission history Received: 1 June 2024 Accepted: 4 December 2024 Permissions Request permissions for this article. Acknowledgments We thank members of the Frank laboratory for inspiration and discussion. P. Cartwright and M. Travert are acknowledged for providing Podocoryna sequences. All microscopy work was conducted at the Microscopy and Imaging Core Facility of the University of Galway.
Tgfβ signaling stimulates glycolysis to promote the genesis of synovial joint interzone in developing mouse embryonic limbs
MATERIALS AND METHODS All mouse work was approved by the Children’s Hospital of Philadelphia Animal Care and Use Committee (IACUC approval number IAC 21-001296). Mice were housed at 22°C with a 12-hour light cycle (6 a.m. to 6 p.m.) and free access to food and water. Both male and female mice were analyzed in the study. Prx1Cre, Col2Cre (line 3), Gdf5Cre, Glut1f/f, Tgfβr2f/f, Ihh−/−, and β-cateninf/f mouse lines are as previously described (13, 26, 27, 32–35).
Blocking the isoflavone chemoreceptor in Phytophthora sojae to prevent disease
Research Article PLANT SCIENCES INTRODUCTION Chemotaxis is crucial for flagellated pathogens to initiate infection, as this process permits these pathogens to find their hosts. Blocking chemotaxis process, which is currently in the proof-of-concept stage, is a promising strategy to reduce disease pressure (1, 2). Oomycetes belong to the Stramenopila and produce biflagellated zoospores as the primary source of infection, which show chemotaxis toward exudates of host plants (3, 4).
NAC regulates metabolism and cell fate in intestinal stem cells
METHODS All mouse experiments were carried out with the approval of the NKI Animal Welfare Body and the NKI-AVL Institutional Review Board, according to the ethical and procedural guidelines established by Dutch law. Experiments in this study included female and male C57BL/6 mice with ages between 8 and 12 weeks old, all bred in-house at the Netherlands Cancer Institute. The animals were generated as described previously (15).
Photophysics-informed two-photon voltage imaging using FRET-opsin voltage indicators
Published In Science Advances Volume 11 | Issue 2 January 2025 Article versions Submission history Received: 1 April 2024 Accepted: 4 December 2024 Permissions Request permissions for this article. Acknowledgments We thank D. Itkis, J. Xu, M. Howell, R. F. Hayward, Y. Wang, A. Preecha, S. Begum, C. Bodden, D. Wong-Campos, B. H. Lee, and E. Perets for technical assistance and helpful discussions.
Tunable in-plane conductance anisotropy in 2D semiconductive AgCrP2S6 by ion-electron co-modulations
Research Article MATERIALS SCIENCE INTRODUCTION Two-dimensional (2D) materials (1, 2) are characterized by anisotropic structures and properties between in-plane and out-of-plane directions (3). Anisotropy within the in-plane is also found in some 2D materials, giving an additional degree of freedom to tune their electrical, optical, and thermal behaviors, which is not possible for in-plane isotropic 2D materials.
The initial solar system abundance of 60Fe and early core formation of the first asteroids
INTRODUCTION Short-lived radioactive (SLR) systems (e.g., 26Al-26Mg, 53Mn-53Cr, 60Fe-60Ni, 182Hf-182W, and 146Sm-142Nd) are key to establish a relative chronology of events that took place during the early solar system (ESS), such as condensation processes, chondrule formation, core-mantle differentiation, and crystallization of magma oceans in planetary bodies [e.g., (1)]. 26Al is an SLR isotope (T1/2 = 0.705 ± 0.024 Myr) (2) of a major element making terrestrial planets.
Spin caloritronics as a probe of nonunitary superconductors
Research Article CONDENSED MATTER PHYSICS INTRODUCTION Classification of superconducting states and identification of unusual superconductivity underlie both the efforts to understand mechanisms of electron pairing and applications of superconducting materials.
Advances in engineering nanoparticles for magnetic particle imaging (MPI)
Review HEALTH AND MEDICINE INTRODUCTION Modern medical science has progressed rapidly for the benefit of humanity; however, proper diagnosis remains a necessity before treatment (1). Medical imaging has a rich history of using contrast agents and tracers to facilitate diagnosis and treatment; however, efficacy is heavily dependent on the quality of the image.
Subthreshold repetitive transcranial magnetic stimulation induces cortical layer-, brain region-, and protocol-dependent neural plasticity
Research Article NEUROSCIENCE INTRODUCTION Repetitive transcranial magnetic stimulation (rTMS) is an extremely attractive tool in both basic and clinical neuroscience as there are very few tools that can noninvasively alter neural activity and neural plasticity in the human brain.
Open-set deep learning-enabled single-cell Raman spectroscopy for rapid identification of airborne pathogens in real-world environments
Research Article APPLIED SCIENCES AND ENGINEERING INTRODUCTION Bacterial infections are a leading cause of global mortality and are responsible for >7.7 million deaths annually (1, 2). Bio-aerosols are critical vehicles for airborne pathogen transmission between the environment and humans (3–5).
Electrical signaling and coordinated behavior in the closest relative of animals
Research Article ORGANISMAL BIOLOGY INTRODUCTION Animals move through and interact with their environments in ways unique to life on earth. Calcium signaling is at the crux of this sensory-behavioral integration, playing a role in every modality from initial signal detection to downstream responses. This is achieved through dynamic control of free cytoplasmic calcium concentrations, and modulation of entry, release, and clearance.
Retraction
Information & Authors Information Published In Science Advances Volume 11 | Issue 1 January 2025 Copyright © 2025 American Association for the Advancement of Science. Article versions Authors Affiliations Department of Molecular Bacteriology, Research Institute for Microbial Diseases, Osaka University, 3-1 Yamada-oka, Suita, Osaka 565-0871, Japan. Department of Molecular Bacteriology, Research Institute for Microbial Diseases, Osaka University, 3-1 Yamada-oka, Suita, Osaka 565-0871, Japan.
NAC-mediated ribosome localization regulates cell fate and metabolism in intestinal stem cells
Abstract Intestinal stem cells (ISCs) face the challenge of integrating metabolic demands with unique regenerative functions. Studies have shown an intricate interplay between metabolism and stem cell capacity, however it is still not understood how this process is regulated. Combining ribosome profiling and CRISPR screening in intestinal organoids, we show that RNA translation is at the root of this interplay.
Earliest directly dated rock art from Patagonia reveals socioecological resilience to mid-Holocene climate
Published In Science Advances Volume 10 | Issue 7 February 2024 Article versions Submission history Received: 26 August 2023 Accepted: 11 January 2024 Permissions Request permissions for this article. Acknowledgments We thank L. A. Borrero for insights and comments on the manuscript, C. Llano for suggestions on the macrobotanical record, and A. Tessone for the discussion on the isotope results. The paper was improved by the incisive comments from the reviewers.
Quando a ansiedade é financeira
Faço parte de uma família numerosa de classe média, sem formação superior, que repetia muitas vezes que o dinheiro não cai das árvores. Que só se consegue com muito trabalho e que, portanto, ele custa a ganhar. Também se comentava à mesa sobre a vida dos outros que iam bem, reforçando que “o dinheiro abre todas as portas”. Ou sobre a nossa própria vida “ruidosa”, justificando as discussões permanentes com o ditado “numa casa em que não há pão todos ralham e ninguém tem razão”.
Carbonate compensation depth drives abyssal biogeography in the northeast Pacific - Nature Ecology & Evolution
Abstract Abyssal seafloor communities cover more than 60% of Earth’s surface. Despite their great size, abyssal plains extend across modest environmental gradients compared to other marine ecosystems. However, little is known about the patterns and processes regulating biodiversity or potentially delimiting biogeographical boundaries at regional scales in the abyss.
Loss of Control over Eating, Inhibitory Control, and Reward Sensitivity in Children and Adolescents: A Systematic Review
Abstract : Overview: In recent years, there has been increasing clinical and empirical interest in the concept of pediatric loss of control over eating, particularly about its link with the executive functions related to the concept of impulsivity, such as inhibitory control and reward sensitivity. However, there has yet to be a comprehensive literature synthesis about the associations between these variables.
Volcanically hosted venting with indications of ultramafic influence at Aurora hydrothermal field on Gakkel Ridge - Nature Communications
Abstract The Aurora hydrothermal system, Arctic Ocean, hosts active submarine venting within an extensive field of relict mineral deposits.
“Não gosto da minha cara.” Os adolescentes que não querem deixar cair a máscara
Tem acesso livre a todos os artigos do Observador por ser nosso assinante. Primeiro veio o medo do vírus invisível, mas também a rejeição das máscaras estranhas e desconfortáveis.
COP26 e a esperança no fator humano
Tem acesso livre a todos os artigos do Observador por ser nosso assinante. Neutralizar as emissões de carbono, conter o aumento da temperatura em 1,5 graus ou mobilizar financiamento são metas ambiciosas colocadas em cima da mesa na COP26, em Glasgow. Mas, e onde fica o fator Humano?
Chicotadas no Macaquinho do Chinês: professores contam casos na Bélgica e no Brasil inspirados no Squid Game. O que dizem os especialistas?
Obrigado por ser nosso assinante. É com o seu apoio que escrevemos estes e outros artigos de fundo, exclusivos a assinantes. Tal como uma criança copia um desenho com papel vegetal, as situações parecem decalcadas uma da outra. Ou, entrando no espírito da série Squid Game, um jogo de Dalgona — com um alfinete, é preciso picotar uma forma dentro de um biscoito de açúcar, sem deformar o desenho original. Pelo meio, as duas histórias têm o Atlântico a separá-las. De um lado Brasil, do outro, Bélgica.
Uma Agenda da Juventude para a Saúde 2030 na voz dos jovens
A Agenda da Juventude para a Saúde 2030 foi entregue e apresentada pelo Conselho Nacional de Saúde à Sra. Ministra da Saúde, ao Sr. Ministro da Educação e ao Sr. Presidente da Assembleia da República no passado dia 21 de maio, num claro incentivo a que os decisores políticos deem o seu voto de confiança à voz ativa dos jovens, às suas propostas e soluções objetivas, transformadoras e operacionalizáveis.
O que leva uma criança a tornar-se um bully? Quais são os sinais? E o que pode um pai fazer?
É um fenómeno que está presente na vida de muitas crianças e adolescentes, por vezes com contornos mais graves. O vídeo divulgado recentemente, que mostra um jovem a ser atropelado no Seixal depois de fugir das colegas que o insultavam, voltou a chamar a atenção para um problema muitas vezes escondido, mas que, segundo dados da GNR, afetou mais de 5.600 crianças em 2020.
Para quando a avaliação de riscos psicossociais nas escolas portuguesas?
O foco desta semana vai para o bem-estar dos professores portugueses no trabalho! Com a publicação do Relatório da Comissão Europeia sobre a carreira, o desenvolvimento e o bem-estar dos professores na Europa, coloca-se uma vez mais a escrutínio público a já conhecida exposição dos professores a fatores de stress psicossocial, nomeadamente ao nível das condições e da organização do seu trabalho, ou até das relações que estabelecem com as diferentes estruturas e intervenientes nas escolas.
10 sugestões para ajudar o seu filho a recuperar da perda de aprendizagens no confinamento
i ▲Em casa, o foco dos pais deve ser na parte emocional do processo de aprendizagem Getty Images ▲Em casa, o foco dos pais deve ser na parte emocional do processo de aprendizagem Getty Images A primeira regra para os pais é que não tentem ser professores, mas há muitas formas de ajudar as crianças a passar pela pandemia com menos efeitos negativos nas aprendizagens. 13 Mar 2021, 21:09 Esqueça a tabuada. Esqueça a dinastia Afonsina. Esqueça a conjugação do verbo “sein” em alemão.
Depois da Covid, o bullying. O que deve fazer se o seu filho for posto de parte na escola?
i ▲Os serviços do Ministério da Educação não têm registo de queixas de crianças que tenham sido vítimas de bullying depois de regressarem de quarentena AFP via Getty Images ▲Os serviços do Ministério da Educação não têm registo de queixas de crianças que tenham sido vítimas de bullying depois de regressarem de quarentena AFP via Getty Images É uma preocupação que toma conta dos pais de crianças infetadas: e se, no regresso à escola, forem postas de parte?
Maternal Eating Behavior and Problematic Eating Behaviors of Children Undergoing Weight Loss Treatment: A Cluster Analysis
Introduction According to recent data from the Childhood Obesity Surveillance Initiative 2019 (COSI), 29.6% of Portuguese children between 6 and 8 years of age have overweight or obesity.1 Results from the Portuguese Generation XXI birth cohort study added critical information about the rising rates of obesity prevalence with age, from 10.6% at age 4 to 16.8% at age 10.2 Despite the genetic vulnerability being a well-established risk factor contributing to the development of obesity,...
Era uma Vez um Coronavírus contado às Crianças…
As células brancas do nosso sangue são como comandantes da polícia do corpo humano, sempre dispostos a combater e a matar a maioria dos germes, sejam eles vírus ou bactérias. Esses "matadores de germes" constituem o sistema imunitário. Ainda assim, alguns vírus, ainda que muito pequenos, alteram-se para evitar serem detetados e podem fazer as pessoas adoecer, sobretudo quando são mais fortes que o nosso sistema imunitário.
Já ouviu falar que Devagar se vai ao Longe?
De janeiro a abril são frequentes as preocupações e pedidos de rastreio e de avaliação pedagógica ou psicológica do que mais vulgarmente é designado de "prontidão escolar". Já lá vamos ao conceito… A idade é o critério principal de entrada para o 1º ano de escolaridade. É assim em Portugal e na generalidade dos países da Europa, definido num leque que varia entre a entrada aos 4 anos (e.g. Irlanda do Norte) e aos 7 anos (e.g. Finlândia).
Escolas SaudávelMente que Escrevem o Futuro
São hoje já alguns os exemplos de uma liderança efetiva e transformadora nas escolas, que envolvem políticas, planos e práticas inclusivas, que preveem modelos de trabalho em equipas multidisciplinares e a participação de todos - pais/cuidadores, alunos, docentes, assistentes operacionais e outros profissionais - nas tomadas de decisão da escola, que estão atentas à saúde psicológica e bem-estar dos seus próprios agentes educativos, que apostam na literacia em saúde psicológica e no...
Mais Psicologia, mais progresso humano
Saúde Autor Sofia RamalhoSeguirA seguir 4/9/2019, 0:10 Partilhe A Psicologia e os psicólogos são cada vez mais necessários, em todos os ciclos da vida humana, intervindo para ajudar a lidar com o impacto das mudanças pessoais, sociais, ecológicas ou culturais. Celebra-se a 4 de Setembro, e pela segunda vez, o Dia Nacional do Psicólogo, consagrado pela Assembleia da República na Resolução nº 147/2018.
Desenvolvimento, Cidadania, e Psicologia nas Escolas
43 dias para o final do ano letivo no Ensino Básico e Secundário, e 50 medidas de política educativa que serão avaliadas quanto ao respetivo grau de concretização e eficácia. No nosso país, cada Escola refletirá sobre a eficácia dos seus novos processos e projetos educativos, e imagino que, ainda este ano, serão elas próprias avaliadas no âmbito da Avaliação Externa das Escolas.
Psicologia e Sociedade?
"A ciência psicológica ocupa e ocupará as agendas humana, sociopolítica e económica e protagoniza a profissão para o século XXI".
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