Soo Lim
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Articles by Soo Lim
Development of Pentaplex Reverse Transcription Droplet Digital PCR Assay for Simultaneous Detection and Absolute Quantification of HIV-1, HIV-2, HCV, and HBV With Internal Control
BLAST basic local alignment search tool CI confidence interval CV coefficient of variation ddPCR droplet digital polymerase chain reaction dPCR digital polymerase chain reaction HBV hepatitis B virus HCV hepatitis C virus HIV human immunodeficiency virus HIV-1 human immunodeficiency virus type 1 HIV-2 human immunodeficiency virus type 2 IC internal control ISO International Organization for Standardization IVD in vitro diagnostics LLoQ lower limit of quantification LoD limit of detection NCBI...
Clinical obesity in Asian people: bridging the gap between adiposity and disease
Abstract This Perspective argues for a reconceptualization of clinical obesity in Asian populations, moving beyond BMI-centric definitions towards an adiposity-based and function-based framework.
ASC4OPT: asciminib treatment optimization study in patients with chronic myeloid leukemia in chronic phase previously treated with two or more tyrosine kinase inhibitors
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Abstract The ASC4OPT non-comparative phase 3b study (NCT04948333) evaluates asciminib once daily (QD) or twice daily (BID) in chronic myeloid leukemia in chronic phase (CML-CP) treated with ≥2 tyrosine kinase inhibitors (TKIs). This study enrolled 169 patients not in major molecular response (MMR), with unsatisfactory response (intolerant, warning or failure) as defined by European LeukemiaNet (ELN) 2020 criteria.
By Andreas Hochhaus Verified, Philipp le Coutre, Dragana Milojkovic, Soo Lim, Carolina Pavlovsky, Thanh Nguyen, Thanh Trúc Nguyễn, Thành Dương Nguyễn, Franck Nicolini, Beatriz Moiraghi, Sebastian Grosicki, Gabriel Etienne, Massimo Breccia, Charles Chuah, Himanshu Pokhriyal, Carla Boquimpani, Fernando Marco de Lucas, Roberto Abi Rached, Aswin IC, Peter Schuld, Virginia Pilipovic, Franz Alisch
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Nature
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Type 2 diabetes mellitus
Abstract Type 2 diabetes mellitus (T2DM) is a chronic, progressive disease driven by a complex interplay of genetic, biological, behavioural and social factors. The epidemiology of T2DM has shifted considerably, largely attributable to increasing obesity rates.
A Robust Spectro-Histopathological Diagnostic Method for Improved Gastric Cancer Detection
Cite Jump to ExpandCollapse ArticleMarch 4, 2026 A Robust Spectro-Histopathological Diagnostic Method for Improved Gastric Cancer Detection Click to copy article linkArticle link copied! Jin Il Jang Jin Il Jang Department of Chemistry, Kookmin University, 77, Jeongneung-ro, Seongbuk-gu, Seoul 02707, Republic of Korea Myeong-Cherl Kook Myeong-Cherl Kook Department of Pathology, National Cancer Center Hospital, 323 Ilsan-ro, Ilsandong-gu, Goyang-si, Gyeonggi-do 10408, Republic of Korea Soo...
Dose‐Escalation Regimens for Incretin Mimetics in Type 2 Diabetes Are Associated With Tolerance for Nausea and Vomiting
1 Introduction Incretin mimetics are glucose-lowering medications for the treatment of Type 2 diabetes, originally developed based on the glucose- and body-weight-lowering effects of glucagon-like peptide-1 (GLP-1).
Utility of continuous glucose monitoring in people with type 2 diabetes on insulin-based regimens in clinical practice: A case series and expert opinion
Keywords Glucose monitoring Continuous glucose monitoring Expert opinion Insulin Type 2 diabetes mellitus Get full text access Log in, subscribe or purchase for full access. References 1. International Diabetes Foundation. IDF Diabetes Atlas, 11th Edition 2025 [cited 2025 September 04]. Available from: https://diabetesatlas.org/resources/idf-diabetes-atlas-2025. 2. American Diabetes Association Professional Practice Committee. 9.
Obesity phenotypes and atherogenic dyslipidemias
Corresponding Author Ian J. Neeland Department of Medicine, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA Division of Cardiovascular Medicine, University Hospitals Harrington Heart and Vascular Institute, University Hospitals Cleveland Medical Center, Cleveland, Ohio, USA Correspondence Ian J.
Cardiometabolic and renal benefits of sodium–glucose cotransporter 2 inhibitors - Nature Reviews Endocrinology
Abstract The therapeutic scope of sodium–glucose cotransporter 2 (SGLT2) inhibitors has expanded beyond glycaemic regulation in the management of diabetes mellitus. Studies published in the past few years highlight their substantial effect on cardiovascular outcomes, notably in decreasing mortality and the need for heart failure-related hospitalization. These agents also lead to pronounced improvements in a range of renal outcomes.
Once-weekly semaglutide 2·4 mg in an Asian population with obesity, defined as BMI ≥25 kg/m2, in South Korea and Thailand (STEP 11): a randomised, double-blind, placebo-controlled, phase 3 trial
aDepartment of Internal Medicine, Seoul National University College of Medicine and Seoul National University Bundang Hospital, Seongnam, South Korea bSection of Endocrinology, Department of Internal Medicine, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand cNovo Nordisk Pharmaceuticals, Beijing, China dNovo Nordisk, Copenhagen, Denmark eDepartment of Family Medicine, Hallym University Sacred Heart Hospital, Anyang-si, South Korea fDepartment of Family Medicine, Konyang...
Clinical characteristics and treatment outcomes of bilateral myopic macular neovascularization in high myopic patients
1 INTRODUCTION High myopia is one of the leading causes of irreversible vision loss worldwide; this is especially relevant in East Asia, where the prevalence of myopia is increasing (Wong & Saw, 2016).
Comparative efficacy and tolerability of currently approved incretin mimetics: A systematic analysis of placebo‐controlled clinical trials
1 INTRODUCTION Incretin mimetics are glucose-lowering medications widely used for the management of type 2 diabetes mellitus (T2D), originally developed based on the glucose- and weight-reducing effects of glucagon-like peptide-1 (GLP-1).1-3 The newest addition to this class is tirzepatide, the first unimolecular co-agonist acting on both GLP-1 and glucose-dependent insulinotropic polypeptide (GIP) receptors.4-6 While the additive effect of GIP receptor agonism is still being explored, newer...
Preoperative predictors of worsened respiratory status after patent ductus arteriosus ligation in preterm infants
Background Preterm infants with hemodynamically significant patent ductus arteriosus (PDA) may require surgical ligation. Following the surgery, some infants may encounter a deterioration in respiratory status. This study aimed to evaluate the risk factors that can predict worsened respiratory outcomes after PDA surgical ligation.
Timing for a surgically safe and oncologically prompt pancreatoduodenectomy after preoperative biliary drainage in patients with bile duct cancer
Corresponding Author Sang Hyun Shin Division of Hepatobiliary-Pancreatic Surgery, Department of Surgery, Samsung Medical Center, Sungkyunkwan University College of Medicine, Seoul, Republic of Korea Correspondence Sang Hyun Shin, Division of Hepatobiliary-Pancreatic Surgery, Department of Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, 81, Irwon-ro, Gangnam-gu, Seoul 06351, Republic of Korea.
Metabolic syndrome - Nature Reviews Disease Primers
Abstract The metabolic syndrome (MetS) is a multiplex modifiable risk factor for cardiovascular disease, type 2 diabetes mellitus and other health outcomes, and is a major challenge to clinical practice and public health. The rising global prevalence of MetS, driven by urbanization, sedentary lifestyles and dietary changes, underlines the urgency of addressing this syndrome.
Association of pitavastatin use with bone markers and bone mineral density in postmenopausal women
The authors have declared no competing interest. Trial registration: NCT06359353 This work was supported, in part, by grants from Seoul National University Bundang Hospital (B-1902-320-004) and JW Pharmaceutical (06-2019-0128). I confirm all relevant ethical guidelines have been followed, and any necessary IRB and/or ethics committee approvals have been obtained.
Development of a MATLAB‐based graphical user interface to illustrate Coulomb's law and Gauss's law
CONFLICT OF INTEREST STATEMENT None of the authors has a conflict of interest to disclose. REFERENCES 1, , , and , A new educational software package for photovoltaic system feasibility: PVGUI, Int. J. Electr. Eng. Educ. 60 (2023), no. 2, 119–129.
In Between the Cracks
© 2024 HMP Global. All Rights Reserved. Any views and opinions expressed are those of the author(s) and/or participants and do not necessarily reflect the views, policy, or position of the Journal of Invasive Cardiology or HMP Global, their employees, and affiliates. J INVASIVE CARDIOL 2024. doi:10.25270/jic/24.00113. Epub May 7, 2024.
Pancreatic beta‐cell mass and function and therapeutic implications of using antidiabetic medications in type 2 diabetes
INTRODUCTION Type 2 diabetes mellitus is a multifaceted metabolic disorder principally characterized by insulin resistance and a progressive impairment in insulin secretion1. At the core of type 2 diabetes mellitus pathogenesis lies a dynamic interplay between insulin resistance and pancreatic β-cell dysfunction1. In the early stages of type 2 diabetes mellitus, pancreatic β-cells undergo compensatory hyperplasia and enhanced insulin secretion to offset rising metabolic demands2.
Transcatheter Closure of a Coronary Artery to Pulmonary Artery Fistula With Two Sequential Giant Aneurysms
J INVASIVE CARDIOL 2024. doi:10.25270/jic/24.00024. Epub March 4, 2024. A 73-year-old female presented with exertional dyspnea and was found to have a coronary artery to pulmonary artery (PA) fistula with 2 sequential giant aneurysms. Her chest radiograph (Figure, A) showed a mass (#) above the cardiac silhouette.
A 21-years experiences with resected solid pseudopapillary neoplasm in single center.
Background: Although the incidence of solid pseudopapillary neoplasm(SPN) is less than 2% of total pancreas mass, the prevalence appears to be increasing. Most of its prognosis is benign, but it also shows malignant features. This study was conducted to reveal the clinical outcomes of patients who underwent surgery for SPN at a single center.
Development of new platforms for predicting early recurrence and survival in resected gallbladder cancer
Samsung Medical Center, Division of Hepatobiliary-Pancreatic Surgery- Department of Surgery, Seoul, Korea Republic of
Preoperative Prognostic Factors for Intrahepatic Cholangiocarcinoma: Implications for Risk Assessment
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Actual 5-year survival of perihilar cholangiocarcinoma: a retrospective single institutional study
Background: Hilar cholangiocarcinoma (HCCA) is known for its poor prognosis due to the late diagnosis. In order for the long-term survival, curative resection is necessary. However, after surgical resection, the 5-year survival rates vary depending on various literature from 14∼48%. The aim of this study is to evaluate the prognostic factors for long term survival in HCCA
The Role of Cilostazol, a Phosphodiesterase-3 Inhibitor, in the Development of Atherosclerosis and Vascular Biology: A Review with Meta-Analysis
All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.
Cancers | Free Full-Text | Survival Comparison of Different Operation Types for Middle Bile Duct Cancer: Bile Duct Resection versus Pancreaticoduodenectomy Considering Complications and Adjuvant Treatment Effects
All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.
Thermally induced atomic reconstruction into fully commensurate structures of transition metal dichalcogenide layers - Nature Materials
Abstract Twist angle between two-dimensional layers is a critical parameter that determines their interfacial properties, such as moiré excitons and interfacial ferro-electricity. To achieve better control over these properties for fundamental studies and various applications, considerable efforts have been made to manipulate twist angle.
Prognosis of pancreaticoduodenectomy in octogenarians for pancreatic ductal adenocarcinoma with propensity score matched analysis
Corresponding Author Sang Hyun Shin Division of Hepatobiliary-Pancreatic Surgery, Department of Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea Correspondence Professor Sang Hyun Shin, Division of Hepatobiliary-Pancreatic Surgery, Department of Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, 81, Irwon-Ro, Gangnam-gu, Seoul, South Korea.
Cardiovascular efficacy and safety of antidiabetic agents: A network meta‐analysis of randomized controlled trials
Table S1. Search strategy in detail. Table S2. Definition of cardiovascular events. Table S3. Definition of renal outcomes. Table S4. Definition of hypoglycaemia. Table S5. Evaluation of global inconsistency by design-by-treatment interaction model. Table S6. Evaluation of local inconsistency by node-splitting analysis. Figure S1. PRISMA flow diagram for studies included in our meta-analysis. Figure S2. Risk-of-bias among trials included in our network meta-analysis. Figure S3.
Survival Benefit after Shifting from Upfront Surgery to Neoadjuvant Treatment in Borderline Resectable Pancreatic Cancer
1. Introduction Pancreatic cancer is an aggressive malignant tumor, and its incidence has increased by 1% annually since the 2000s. However, the 5-year survival rate has increased by only 6–11% over the past few decades, showing a stagnant outcome compared to other cancers, including gastric cancer and colorectal cancer [1]. Surgical resection provides an opportunity for curative potential, but resectable cases account for only 20–25% at the time of diagnosis [2].
Precision Medicine in Erythropoietin Deficiency and Treatment Resistance: A Novel Approach to Management of Anaemia in Chronic Kidney Disease
1. Introduction Anaemia is a common complication of chronic kidney disease (CKD) and can significantly impact the quality of life of affected individuals. The cause of anaemia in patients with deteriorating kidney function is multifactorial. As the most common causes, when iron and nutrient deficiencies are ruled out, EPO deficiency is the most likely diagnosis. However, chronic inflammation, blood loss, and hyperparathyroidism are also taken into account.
Comparison of the effects of empagliflozin and sotagliflozin on a zebrafish model of diabetic heart failure with reduced ejection fraction - Experimental & Molecular Medicine
Abstract The sodium-glucose cotransporter 2 (SGLT2) inhibitor empagliflozin (EMPA) and dual SGLT1/2 inhibitor sotagliflozin (SOTA) are emerging as heart failure (HF) medications in addition to having glucose-lowering effects in diabetes mellitus (DM). However, the precise mechanism underlying this cardioprotective effect has not yet been elucidated. Here, we evaluated the effects of EMPA and SOTA in a zebrafish model of DM combined with HF with reduced ejection fraction (DM-HFrEF).
Asia-Pacific consensus recommendations for application of continuous glucose monitoring in diabetes management
Table 6Consensus statements for optimizing the use of CGM in people with type 2 diabetes and on treatment with oral GLDs alone or with basal/premix insulin with or without other GLDs. *‘Continual use’ refers to the use of CGM in a consistent manner based on the optimal number of recommended sensors, subject to patient factors, and availability of resources.
Effect of socioeconomic status and healthcare provider on post-transplantation care in Malaysia: A multi-centre survey of kidney transplant recipients
Loading metrics Open Access Peer-reviewed Research Article Abstract Introduction As the rate of end-stage kidney disease rises, there is an urgent need to consider the catastrophic health expenditure of post-transplantation care. Even a small amount of out-of-pocket payment for healthcare can negatively affect households’ financial security. This study aims to determine the association between socioeconomic status and the prevalence of catastrophic health expenditure in post-transplantation care.
Buerger’s Disease as a Cause of Post-Operative Skin Necrosis: A Case Report
This is an early access version, the complete PDF, HTML, and XML versions will be available soon. Open AccessCase Report by Jong Hyup Kim , Hoon Kim , In Chang Koh and Soo Yeon Lim * Department of Plastic and Reconstructive Surgery, Myunggok Medical Research Institute, Konyang University Hospital, College of Medicine, Konyang University, Daejeon 35365, Republic of Korea * Author to whom correspondence should be addressed. J. Pers. Med.
Pathological Response Predicts Survival after Pancreatectomy Following Neoadjuvant FOLFIRINOX for Pancreatic Cancer
This is an early access version, the complete PDF, HTML, and XML versions will be available soon. Open AccessArticle by Hyun Jeong Jeon , Hye Jeong Jeong , Soo Yeun Lim , So Jeong Yoon , Hongbeom Kim , In Woong Han , Jin Seok Heo and Sang Hyun Shin * Division of Hepatobiliary-Pancreatic Surgery, Department of Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul 06351, Republic of Korea * Author to whom correspondence should be addressed.
Clinical Outcome of Resected Non-Ampullary Duodenal Adenocarcinoma: A Single Center Experience
This is an early access version, the complete PDF, HTML, and XML versions will be available soon.
Type 2 diabetes
1. Chatterjee S Khunti K Davies MJ Type 2 diabetes. Lancet. 2017; 389: 2239-2251 2. Sun H Saeedi P Karuranga S et al. IDF diabetes atlas: global, regional and country-level diabetes prevalence estimates for 2021 and projections for 2045. Diabetes Res Clin Pract. 2022; 183109119 3. Ogurtsova K Guariguata L Barengo NC et al. IDF diabetes atlas: global estimates of undiagnosed diabetes in adults for 2021. Diabetes Res Clin Pract. 2022; 183109118 4.
Deadly Smoke: Feeding Children Kills Cafeteria Staff
Asia-Pacific, Education, Health, TerraViva United Nations, Youth Thought Leaders Opinion Reprint | | Print | Seoul, Sep 28 2022 (IPS) - During my summer break this year, I read a news article about five school cafeteria workers who had died of lung cancer. Due to these incidents, a union of cafeteria workers, wearing their aprons and holding their lunch trays, held a protest in front of the President’s office on a scorching summer day.
Real world usage of sulphonylurea in Asian patients with type 2 diabetes using the Joint Asia Diabetes Evaluation (JADE) Register
Abstract Aims To explore the patterns of use of oral glucose lowering drugs (OGLDs) in Asian patients with type 2 diabetes (T2D) focusing on sulphonylureas (SU) and to describe the patient profiles according to treatment regimen. Methods We conducted a cross-sectional analysis of data from adults with T2D from 11 Asian countries/regions with structured assessment enrolled in the prospective Joint Asia Diabetes Evaluation (JADE) Register between November 2007 and December 2019.
Initial combination of metformin, sitagliptin, and empagliflozin in drug‐naïve patients with type 2 diabetes: Safety and metabolic effects
1 INTRODUCTION Compared with traditional stepwise add-on therapy, proactive combination therapy with antidiabetic agents having a different mode of action has shown high efficacy for glycaemic control in patients with type 2 diabetes (T2D).1 A study using an initial triple combination with metformin, pioglitazone, and exenatide showed significantly better long-term glycaemic control than a conventional stepwise approach.2 Similarly, in Korean patients, initial triple combination therapy with...
Comparison betweeen dapagliflozin add-on therapy and insulin dose escalation in patients with uncontrolled type 2 diabetes treated with insulin
Abstract Aim To assess the efficacy and tolerability of adjunct therapy with a sodium-glucose cotransporter-2 inhibitor, dapagliflozin, compared with insulin escalation for patients with uncontrolled type 2 diabetes on current insulin therapy. Methods A 12-month retrospective case–control study of patients with glycated hemoglobin (HbA1c) > 7% on insulin therapy.
Multicolor-Raman Analysis of Korean Paintworks: Emission-like Raman Collection Efficiency
Multicolor-Raman Analysis of Korean Paintworks: Emission-like Raman Collection Efficiency It has been reported that the scattering cross-sections of resonance Raman spectra strongly depend on the resonance between the laser's excitation energy and the electronic absorption band of pigments in solution. However, the actual collection of scattered photons is affected by diffuse scattering and self-absorption when studying painted colorants in artworks.
Reply to: Autonomic dyshomeostasis in patients with diabetes mellitus during COVID-19
My colleagues and I published a comprehensive Review on coronavirus disease 2019 (COVID-19) and diabetes mellitus in November 2020 (Lim, S., Bae, J. H., Kwon, H. S. & Nauck, M. A. COVID-19 and diabetes mellitus: from pathophysiology to clinical management. Nat. Rev. Endocrinol. 17, 11–30 (2021)1).
Effect of Increased Levothyroxine Dose on Depressive Mood
Abstract and Introduction Abstract Objective: Depressive mood consequent to hypothyroidism can be reversed with levothyroxine (LT4) replacement therapy. However, it is unclear whether increasing LT4 dose confers additional mood benefits. Design and Patients: A single-blinded before-and-after study of 24 patients with hypothyroidism who were aged 65 years or older and undergoing LT4 replacement therapy with stable doses.
International students and migrant workers turn to charity amid COVID economic collapse
International students and migrant workers turn to charity amid COVID economic collapse Desperate international students and migrant workers are queuing for up to two hours to receive food and basic household needs. BY SOO LIM A viral TikTok video which displays an extensive line of people, queuing to reach a food relief provider in Melbourne's CBD has highlighted the extent of struggling international students and workers.
Turkey's femicide victims framed out of Instagram selfie challenge
Participants in an Instagram self-challenge have found themselves at the centre of a misappropriation storm. BY SOO LIM A new trend capturing attention on Instagram has unwittingly revealed a toxic side of social media activism. From last week, dozens of black and white selfies flooded the popular social media site, containing captions promoting the empowerment of women.
Effect of cilostazol on carotid plaque volume measured by 3D ultrasound in patients with type 2 diabetes: FANCY study
ORIGINAL ARTICLE Dong‐Hwa Lee MD Department of Internal Medicine, Chungbuk National University Hospital, Cheongju, South Korea Department of Internal Medicine, Seoul National University College of Medicine and Seoul National University Bundang Hospital, Seongnam, South Korea The first two authors contributed to this study equally.
Face Masks and Containment of Coronavirus Disease 2019 (COVID-19): Experience from South Korea
Sir, A novel coronavirus (SARS-CoV-2) emerged in the city of Wuhan, China in December 2019 and has now spread worldwide. Since the end of February 2020, the COVID-19 spread to South Korea and there was a rapid increase in COVID-19 cases from the end of February to mid-March. Fortunately, due to the efforts from both government and private sectors, the spread of the disease has been declining rapidly and only a few cases were reported in May.
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