Soode Moghadas Jafari

Fab–Fc and Fab–Fab interactions of variable strength and valency contribute to the high concentration viscosity of IgG1 antibodies Edited by Anthony A. Kossiakoff, The University of Chicago, Chicago, IL; received September 19, 2025; accepted February 23, 2026 Significance Subcutaneous injection is increasingly favored over intravenous infusion for antibody therapies such as IgG for multiple reasons including faster administration and greater convenience for patients.

Abstract Germinal centers (GCs) are specialized lymphoid structures in which activated B cells undergo clonal selection and B cell receptor (BCR) somatic hypermutation to generate high-affinity antibodies. Previous work has shown that T cells expressing choline acetyltransferase (ChAT), the enzyme that synthesizes acetylcholine (ACh), are linked to the production of high-affinity antibodies in the GC response.