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Sridevi Challa on Muck Rack

Sridevi Challa

As seen in: MDPI, BioRxiv, Cell Chemical Biology, Cell Press, Annals of Allergy, Asthma & Immunology
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Articles

RBN-2397, a PARP7 Inhibitor, Synergizes with Paclitaxel to Inhibit Proliferation and Migration of Ovarian Cancer Cells

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By Alexandra N. Spirtos, Marwa W. Aljardali, Sridevi Challa, Sneh Koul
| BioRxiv
Abstract Objectives: Mono(ADP-ribosyl)ation (MARylation), a post translational modification of proteins, is emerging as an important regulator of the biology of cancer cells. PARP7 (TiPARP), a mono (ADP-ribosyl) transferase (MART), MARylates its substrate α-tubulin in ovarian cancer cells, promoting destabilization of microtubules, cell growth, and migration.
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Biological Functions and Therapeutic Potential of NAD+ Metabolism in Gynecological Cancers

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By Anh Nguyen Verified, Sridevi Challa, Anh Quynh, Subin Myong
| MDPI
Nicotinamide phosphoribosyl transferase (NAMPT) regulates the intracellular NAD + levels crucial for cellular redox reactions and NAD + -dependent enzyme function, and it also exhibits cytokine-like activity [ 19 ]. NAMPT influences metabolic disorders and cancer by modulating oxidative stress, apoptosis, lipid metabolism, inflammation, and insulin resistance [ 10 ].
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A PARP14/TARG1-Regulated RACK1 MARylation Cycle Drives Stress Granule Dynamics in Ovarian Cancer Cells

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By Sridevi Challa, Amy Gong, Charles Renshaw, Hyung Bum Kim
| BioRxiv
Abstract Mono(ADP-ribosyl)ation (MARylation), a post-translational modification (PTM) of proteins, is emerging as a critical regulator of ribosome function and translation. Herein, we demonstrate that RACK1, a member of the tryptophan-aspartate repeat (WD-repeat) family of proteins and an integral component of the ribosome, is MARylated by the mono(ADP-ribosyl) transferase (MART) PARP14 in ovarian cancer cells.
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