Stéfanie Primon Muraro

1 Introduction The coronavirus disease 2019 (COVID-19) is characterised by high morbidity and mortality rates in populations with comorbidities, including people with obesity, cardiovascular disease, hypertension, advanced age and type 2 diabetes mellitus (T2D) [1-4]. Obesity is a complex and multifactorial condition and a worldwide public health concern. In individuals with obesity, the imbalance between energy intake and expenditure leads to elevated circulating FFA levels.

Abstract : The COVID-19 pandemic was triggered by the coronavirus SARS-CoV-2, whose peak occurred in the years 2020 and 2021. The main target of this virus is the lung, and the infection is associated with an accentuated inflammatory process involving mainly the innate arm of the immune system.

Abstract Visceral adiposity is a risk factor for severe COVID-19, and a link between adipose tissue infection and disease progression has been proposed. Here we demonstrate that SARS-CoV-2 infects human adipose tissue and undergoes productive infection in fat cells. However, susceptibility to infection and the cellular response depends on the anatomical origin of the cells and the viral lineage.