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Steffi Oesterreich on Muck Rack

Steffi Oesterreich

Blawnox, Pittsburgh
As seen in: Nature, Wiley Online Library, BioRxiv, Cell Press, HemOnc Today, OncLive, Oncology Tube, Pharma Focus Asia
Proud mother, wife, and Breast cancer researcher. @UPMCHillmanCC @PittTweet @UPMCnews @MageeWomens @AdrianVLee #lobmob All views are my own.
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Articles

Quantitative and qualitative patient-reported analysis of misdiagnosis and/or late diagnosis of metastatic lobular cancer

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By Morgan Cody, Hung-Ching Chang, Julia Foldi, Rachel C. Jankowitz, Marija Balic, Tracy Cushing, Carla S. Donnelly, Julia Levine, Nancy Ryan, Claire Turner, George Tseng, Christine Desmedt, Steffi Oesterreich, Adrian Lee, Siobhán Freeney, Lori Petitti, Kirstin Spencer
| Nature Verified
Abstract Invasive lobular breast cancer (ILC), the most common special histologic subtype of breast cancer, may metastasize to atypical sites, including the peritoneum, gastrointestinal tract, ovaries, urinary tract, and orbit. Because metastatic ILC (mILC) is often less FDG-avid and may present after a long disease-free interval with nonspecific symptoms, diagnosis may be delayed or mistaken for other conditions.
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The chemotherapy-induced senescence-associated secretome promotes cell detachment and metastatic dissemination through metabolic reprogramming

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By Aidan Cole, Raquel Buj, Apoorva Uboveja, Evan Levasseur, Alexander Tom, Hui Wang, Katarzyna M. Kedziora, Adam Chatoff, Andrea Andress Huacachino, Mariola M. Marcinkiewicz, Amandine Amalric, Baixue Yang, Naveen Kumar Tangudu, Emily Noonan, Jeff Danielson, Miho Naruse, Amal Taher Elhaw, Sierra White, Danyang Li, Callen T. Wallace, Felicia Lazure, Esther Elishaev, Lauren Borho, Hope A Townsend, Robin Dowell, Aaron Clauset, Matthew Laird, Huda I. Atiya, Denarda Dangaj, Lan G Coffman, George Tseng, Steffi Oesterreich, Andrew V. Kossenkov, Qin Liu, Ana Gomes, Aditi U. Gurkar, Francisco J. Schopfer, Francesmary Modugno, Simon Watkins Verified, Ioannis K. Zervantonakis, Benjamin G. Bitler, Wayne Stallaert, Nadine Hempel, Nathaniel Snyder, Katherine M. Aird, Frederick Keeney, Dorota E. Jazwinska
| Nature Verified
Abstract Cellular senescence is a consequence of many chemotherapeutics that plays context-dependent roles in cancer. Senescent cells secrete an array of factors collectively known as the senescence-associated secretory phenotype (SASP). Here we show that the cisplatin-induced SASP enhances the detachment of high-grade serous ovarian cancer (HGSOC) cells in vitro and dissemination in vivo.
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RET signaling as a mediator of estrogen receptor positive breast cancer brain metastasis

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By Simeng Liu, Geoffrey L. Pecar, Ye Cao, Fangyuan Chen, Abdalla Wedn, Jennifer Atkinson, Jagmohan Hooda, Steffi Oesterreich, Adrian Lee, Osama S. Shah
| Nature Verified
Abstract Brain metastasis (BrM) occurs in 10–15% of patients with estrogen receptor–positive breast cancer (ER + BC) and remains a major clinical challenge with limited therapeutic options. Median survival after BrM diagnosis is approximately 18 months, underscoring the need for new druggable targets. We previously identified recurrent overexpression of the receptor tyrosine kinase RET in BrM relative to matched primary tumors.
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