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Stephen-John Sammut

As seen in: Nature, Genome Medicine, Science Magazine, Cell Reports, Cell Press, Cell Reports Medicine
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Articles

AI-predicted spatial transcriptomics unlocks breast cancer biomarkers from pathology

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By Eldad D. Shulman, Emma M Campagnolo, Roshan Lodha, Youngmin Chung, Amos Stemmer, Thomas Cantore, Beibei Ru, Tian-Gen Chang, Sumona Biswas, Saugato Rahman Dhruba, Sumeet Patiyal, Sushant Patkar, Andrew Wang, Ranjan Barman, Chuhan Wang, Rohit Paul, Tom Hu, MacLean P. Nasrallah, Ellis Patrick, Jean Yang, Yuan Yuan, Karine Shahen Sargsyan, Padma Sheila Rajagopal, Stephen-John Sammut, Stanley Lipkowitz, Peng Jiang, Carlos Caldas, Kenneth Aldape, Joo Sang Lee, Danh-Tai Hoang, Eytan Ruppin, Sarath Chandra Kalisetty, Amy Plotkin, Simon R.V. Knott
| Cell Press Verified
Keywords digital pathology artificial intelligence deep learning breast cancer spatial transcriptomics spatial biomarkers histopathology treatment response prediction HER2 tumor microenvironment Get full text access Log in, subscribe or purchase for full access. References 1. Wu, S.Z. ∙ Al-Eryani, G. ∙ Roden, D.L. ... A single-cell and spatially resolved atlas of human breast cancers Nat. Genet. 2021; 53:1334-1347 2. Wang, X. ∙ Wang, Z. ∙ Liao, Q. ...
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The tumor microenvironment of 14,837 breast cancers is associated with clinical outcome independently of genomic subtypes

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By Kevin Tu, Daniel Guerrero-Romero, Raquel Garcia, Raquel García, Soo-Hwang Teo, Long Nguyen, Long Nguyễn, Stephen-John Sammut, Florian Markowetz, Oscar M. Rueda, Òscar Rueda, Carlos Caldas, Kate Eason, Jia Wern
| Cell Reports Medicine Verified
ArticleOnline now102450Open access 1Cancer Research UK Cambridge Institute, University of Cambridge, Cambridge, UK 2University of Maryland School of Medicine, Baltimore, MD, USA 3Cancer Research Malaysia, No. 1, Jalan SS12/1A, Subang Jaya 47500, Malaysia 4University Malaya Cancer Research Institute, Faculty of Medicine, University Malaya, Kuala Lumpur, Malaysia 5Department of Medicine, University of Toronto, Toronto, ON, Canada 6Breast Cancer Now Toby Robins Research Centre, Institute of...
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Predictability of B cell clonal persistence and immunosurveillance in breast cancer - Nature Immunology

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By Stephen-John Sammut, Bo Sun, Suet-Feung Chin, Leticia De Mattos-Arruda, Joan Seoane, Carlos Caldas
| Nature Verified
Abstract B cells and T cells are important components of the adaptive immune system and mediate anticancer immunity. The T cell landscape in cancer is well characterized, but the contribution of B cells to anticancer immunosurveillance is less well explored. Here we show an integrative analysis of the B cell and T cell receptor repertoire from individuals with metastatic breast cancer and individuals with early breast cancer during neoadjuvant therapy.
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