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Suluxan Mohanraj on Muck Rack

Suluxan Mohanraj

As seen in: Nature, BioRxiv
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Articles

A pan-cancer compendium of 1,294 plasma cell-free DNA methylomes and fragmentomes enabling multicancer detection - Nature Cancer

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By Yong Zeng, Dor D Abelman, Althaf Singhawansa, Nicholas Cheng, Yuanchang Fang, Sasha C. Main, Emma J Bell, Wenbin Ye, Ping Luo, Samantha Wilson, Eric Y. Stutheit-Zhao, Derek Wong, Nadia Znassi, Kui Chen, Suluxan Mohanraj, Enrique Sanz-Garcia, Faiyaz Notta, anand Ghanekar, Philip Awadalla, Benjamin H. Lok, Michael Hoffman, Raymond Kim, Gelareh Zadeh, Scott V. Bratman, Mathieu Lupien, Trevor J. Pugh, Housheng Hansen He
| Nature Verified
Abstract Cell-free DNA analysis via methylation and fragmentation profiling has advanced minimally invasive cancer detection; however, broader application has been limited by small cohorts and inconsistent data processing. Here we collated 1,074 cfMeDIP-seq profiles across 9 studies, comprising cancer samples from 11 cancer types, carriers of Li-Fraumeni syndrome and healthy controls. We developed a uniform computational workflow to mitigate technical and biological confounders across cohorts.
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Immunogenomic profiling of circulating T cells in pediatric cancer patients during standard-of-care

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By Arash Nabbi, Yiyue Jiang, Osvaldo García, Suluxan Mohanraj
| BioRxiv
Abstract While pediatric cancer patients receive intensive chemotherapy, its impact on peripheral T cells and subsequently to disease outcomes are not fully characterized. Here, we assessed T-cell dynamics during treatment, identifying associations with outcomes through immune phenotyping and T-cell Receptor (TCR) sequencing in pediatric solid and hematologic malignancies.
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A comparison of data integration methods for single-cell RNA sequencing of cancer samples

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By Laura Richards, Mazdak Riverin, Suluxan Mohanraj, Shamini Ayyadhury
| BioRxiv
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