An 80-year-old man with a history of hypertension, gastroesophageal reflux disease, and stage 4 chronic kidney disease presented with 2 days of anuria. He felt well until 6 days prior, when he awoke with diffuse muscle cramps following a strenuous day of moving boxes. He subsequently developed oliguria that progressed to anuria. His only medication was omeprazole (20 mg daily). His usual fluid intake had not changed.
Genes in the liver, pancreas and other tissues (not just the brain) keep the various parts of the body in sync. Timing miscues may lead to diabetes, depression and other illnesses Anyone who has ever flown east or west at 500 knots for more than a few hours has experienced firsthand what happens when the body's internal clock does not match the time zone in which it finds itself.