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RIDDEN: Data-driven inference of receptor activity from transcriptomic data
PLoS computational biology. 2025 Jun 16;21(6):e1013188. doi: 10.1371/journal.pcbi.1013188 Q13.82024 Szilvia Barsi 1 2, Eszter Varga 2, Daniel Dimitrov 3, Julio Saez-Rodriguez 3, László Hunyady 1 2, Bence Szalai 1 2 作者单位 +展开 作者单位 1 Institute of Molecular Life Sciences, Centre of Excellence of the Hungarian Academy of Sciences, HUN-REN Research Centre for Natural Sciences, Budapest, Hungary. 2 Department of Physiology, Faculty of Medicine, Semmelweis University, Budapest, Hungary.
RIDDEN: Data-driven inference of receptor activity from transcriptomic data
Citation: Barsi S, Varga E, Dimitrov D, Saez-Rodriguez J, Hunyady L, Szalai B (2025) RIDDEN: Data-driven inference of receptor activity from transcriptomic data. PLoS Comput Biol 21(6): e1013188. https://doi.org/10.1371/journal.pcbi.1013188 Editor: Joshua Welch, University of Michigan, UNITED STATES OF AMERICA Received: December 10, 2024; Accepted: June 3, 2025; Published: June 16, 2025 Copyright: © 2025 Barsi et al.
Differential activation of the inositol 5-phosphatase SHIP2 by EGF and insulin signaling pathways
Keywords receptor tyrosine kinase epidermal growth factor receptor insulin receptor phosphoinositide phosphatidylinositide 3‐kinase biosensor bioluminescence resonance energy transfer SHIP2 phosphatidylinositol 3,4-bisphosphate INTRODUCTION Phosphoinositides (PIPs) are a class of specialized phospholipids that exist in dynamic pools, undergoing rapid interconversion by various enzymes (1).
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