Tahnbee Kim

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Highlights • Tentonin 3/TMEM150C (TTN3) is expressed specifically in murine pancreatic β-cells • TTN3 mediates β-cell swelling upon glucose stimulation and hypotonicity • TTN3 mediates cation current influx upon glucose stimulation and hypotonicity • Genetic ablation of TTN3 in β-cells impairs insulin secretion by glucose Summary Glucose homeostasis is initially regulated by the pancreatic hormone insulin.

New Results Anne-Kathrin Eiselt, Jim Chen, Jon Arnold, Tahnbee Kim, Scott M Sternson doi: https://doi.org/10.1101/620690 Abstract Decision-making guided by self-evaluation of bodily need states (interoception) is thought to be important for cognitive control over eating or drinking. However, interoception of body states is notoriously unreliable because hunger and thirst have similar motivational characteristics.