Tal Nawy

Keywords pancreatic cancer tumor initiation tumor suppression benign-to-malignant transition single-cell biology spatial transcriptomics p53 KRAS inhibitors niche dynamics Introduction Cancer progression is fueled by the accumulation of genetic alterations, yet clonal expansions bearing oncogenic mutations—despite appearing frequently in histologically normal tissues1,2—rarely progress to cancer.3,4,5 Only upon acquiring additional genetic or epigenetic changes do they breach regulatory...

Abstract A key challenge of analyzing data from high-resolution spatial profiling technologies is to suitably represent the features of cellular neighborhoods or niches. Here we introduce the covariance environment (COVET), a representation that leverages the gene–gene covariate structure across cells in the niche to capture the multivariate nature of cellular interactions within it.