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Articles by Tamara Maiuri
In This Issue | PNAS
EARTH, ATMOSPHERIC, AND PLANETARY SCIENCES Scanning electron microscopy reveals the shape and texture of a quartz sand grain from the Mississippi River. Tracing the path of sandstones through texture analysis Quartz sand grains are reshaped by environmental forces when they are transported, developing characteristic surface textures indicative of such forces. Michael Hasson et al.
Distribution of centrality measures on undirected random networks via the cavity method
R. Albert, H. Jeong, A.-L. Barabási, Error and attack tolerance of complex networks. Nature 406, 378–382 (2000). D. S. Callaway, M. E. J. Newman, S. H. Strogatz, D. J. Watts, Network robustness and fragility: Percolation on random graphs. Phys. Rev. Lett. 85, 5468–5471 (2000). H. Jeong, S. P. Mason, A.-L. Barabási, Z. N. Oltvai, Lethality and centrality in protein networks. Nature 411, 41–42 (2001). M. De Domenico, A. Solé-Ribalta, S. Gómez, A. Arenas, Navigability of interconnected networks under random failures. Proc. Natl.
Inverse modeling of 2010–2022 satellite observations shows that inundation of the wet tropics drove the 2020–2022 methane surge | PNAS
S. Szopa et al., "Short-lived climate forcers" in Climate Change 2021: The Physical Science Basis. Contribution of Working Group I to the Sixth Assessment Report of the Intergovernmental Panel on Climate Change (Cambridge University Press, Cambridge, United Kingdom and New York, NY, USA, 2021). J. M. Nicely et al., Changes in global tropospheric OH expected as a result of climate change over the last several decades. J. Geophys. Res. Atmos. 123, 10774–10795 (2018). Q. Zhu, A. M. Fiore, G. Correa, J.-F.
Keeping America “Science Strong”
As a member of the baby-boom generation, I have not experienced a time when US science was not the envy of the world. With US researchers claiming 60 percent of all Nobel Prizes ever awarded in the sciences, America dominates this international competition more decisively than any other nation has in any pursuit that keeps score (1).
AI-accelerated Nazca survey nearly doubles the number of known figurative geoglyphs and sheds light on their purpose
AI-accelerated Nazca survey nearly doubles the number of known figurative geoglyphs and sheds light on their purpose Edited by Joyce Marcus, University of Michigan, Ann Arbor, MI; received April 17, 2024; accepted July 30, 2024 Significance This paper demonstrates how AI accelerates discoveries in archaeology, even in a region as well known as the United Nations Educational, Scientific and Cultural Organization (UNESCO) World Heritage site of Nazca.
Alveolar macrophage function is impaired following inhalation of berry e-cigarette vapor
Alveolar macrophage function is impaired following inhalation of berry e-cigarette vapor Amelia Kulle https://orcid.org/0000-0003-2402-7534, Ziyi Li https://orcid.org/0009-0008-8071-0737, Ashley Kwak, +13 , Mathieu Mancini https://orcid.org/0000-0002-4981-7121, Daniel Young, Daina Zofija Avizonis, Marc Groleau, Carolyn J. Baglole, Marcel A. Behr https://orcid.org/0000-0003-0402-4467, Irah L.
Akira Endo, who discovered a “penicillin” for heart attacks (1933 to 2024)
Akira Endo, a scientist whose discovery saved millions of lives, died on June 5, 2024, at the age of 90. In 1972, while working as a biochemist at the Sankyo Pharmaceutical Company in Tokyo, Endo discovered a natural product that blocked the synthesis of cholesterol in animal cells. Isolated from a blue-green mold, Endo’s chemical was the first statin, a class of drugs that lower plasma cholesterol and prevent heart attacks.
Poly ADP-Ribose Signaling is Dysregulated in Huntington Disease Patients
Abstract Huntington disease (HD) is a genetic neurodegenerative disease caused by CAG expansion in the Huntingtin (HTT) gene, translating to an expanded polyglutamine tract in the huntingtin (HTT) protein. Age at disease onset correlates to CAG repeat length but varies by decades between individuals with identical repeat lengths. Genome-wide association studies link HD modification to DNA repair and mitochondrial health pathways.
Poly ADP-Ribose Signaling is Dysregulated in Huntington’s Disease Patients
Abstract Huntington’s disease (HD) is an autosomal dominant genetic neurodegenerative disease caused by a CAG expansion in the Huntingtin (HTT) gene, translating to an expanded polyglutamine tract in the huntingtin (HTT) protein. Age at disease onset is correlated to CAG repeat length, but varies by decades between individuals with identical repeat lengths. Genome-wide association studies link HD modification to DNA repair and mitochondrial health pathways.
Single Cell Technologies Define New Therapeutic Avenues for Huntington’s Disease
Using two independent single-cell transcriptomics technologies, Lee et al. have cataloged transcriptional changes in the subset of striatal neurons hit hardest in Huntington’s disease. One downregulated pathway, oxidative phosphorylation, may also explain their observed release of mitochondrial-encoded RNAs. To read this article in full you will need to make a payment Purchase one-time access Read-It-Now Purchase access to all full-text HTML articles for 6 or 36 hr at a low cost.
Fresh Updates from First Huntingtin Lowering Study Publication
Hot off the presses - New publication gives more details about the results of Ionis and Roche's safety study with a Huntingtin-lowering ASO By Dr Jeff Carroll May 07, 2019 Edited by Dr Tamara Maiuri Today saw the publication of the first manuscript describing a huntingtin lowering trial in Huntington’s disease patients. This study, sponsored by Ionis and Roche, provided clear evidence of researchers’ ability to safely reduce mutant huntingtin protein in the spinal fluid.
High-mobility group box 1 links sensing of reactive oxygen species by huntingtin to its nuclear entry
Susie Son, Laura E. Bowie, Tamara Maiuri, Claudia L. K. Hung, Carly R. Desmond, Jianrun Xia and Ray Truant1 From the Department of Biochemistry and Biomedical Research, McMaster University, Hamilton, Ontario L8S 4L8, Canada ↵1 To whom correspondence should be addressed: HSC4N54 1200 Main St. West, Hamilton, Ontario L8N3Z5, Canada. Tel.: 905-525-9140; Fax: 905-522-9033; E-mail: truantr{at}mcmaster.ca.
High-mobility group box 1 links sensing of reactive oxygen species by huntingtin to its nuclear entry
High-mobility group box 1 links sensing of reactive oxygen species by huntingtin to its nuclear entry Susie Son1, Laura E Bowie1, Tamara Maiuri1, Claudia L.K. Hung1, Carly R Desmond1, Jianrun Xia1 and Ray Truant2* 1McMaster University, Canada 2Biochemsitry and Biomedical Sciences, McMaster University, Canada ↵* Corresponding author; email: truantr{at}mcmaster.ca Author contributions: S.S., C.R.D., and R.T. conceptualization; S.S., L.E.B., C.L.H., and R.T. data curation; S.S., L.E.B., C.L.H.,...
FDA approves a new drug for symptoms of Huntington's disease
Significant news for the Huntington’s disease community this week, as the USA’s drug regulator, the FDA, has formally approved Austedo, also known as deutetrabenazine, for prescribing in HD. This modified form of tetrabenazine helps control chorea, the jerky movements often found in HD patients, but is taken twice rather than three times a day. Tetrabenazine has a long history as a treatment of Huntington’s disease - which we’ve previously covered at HDBuzz here and here.
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