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Tanvi Jain

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Articles

Stress drives plasticity in leaf ageing transcriptional dynamics in Arabidopsis thaliana

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By Joseph Swift, Xuelin Wu, Jiaying Xu, Carl Procko, Tanvi Jain, Natanella Illouz-Eliaz, Joseph R. Nery, Joanne Chory, Joseph R. Ecker
| Nature Verified
Abstract Leaf development is dynamic, enabling plants to modulate their growth in response to environmental cues. Under drought conditions, for instance, the model plant Arabidopsis thaliana restricts leaf growth to conserve water, a strategy that enhances water-use efficiency. While this ‘stress avoidance’ response is well described physiologically, the underlying transcriptional changes that drive such developmental plasticity remain poorly understood.
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Microbiota-mediated induction of beige adipocytes in response to dietary cues

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By Takeshi Tanoue, Manabu Nagayama, Ayumi J. A. Roochana, Samuel Zimmerman, Orr Ashenberg, Tanvi Jain, Ryo Igarashi, Satoshi Sasajima, Kozue Takeshita, Nicola Hetherington, Nobuyuki Okahashi, Masahiro Ueda, Morichika Konishi, Yoshiaki Nakayama, Aki Minoda, Ashwin N. Skelly, Yasuhiko Minokoshi, Nicholas Pucci, Daniel R. Mende, Makoto Arita, Hironori Yamamoto, Shunji Watanabe, Kouichi Miura, Scott W. Behie, Wataru Suda, Toshiro Sato, Koji Atarashi, Mami Matsushita, Shingo Kajimura, Damian R. Plichta, Masayuki Saito, Ramnik Xavier, Kenya Honda
| Nature Verified
Abstract Interactions between diet and the gut microbiota are fundamental to metabolic health, shaping energy balance and disease susceptibility1,2,3,4,5. However, the underlying mechanisms by which dietary and microbial factors converge to regulate host physiology remain unclear. Here we show that protein availability profoundly modulates the functional landscape of the gut microbiota and promotes remodelling of white adipose tissue (WAT).
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Multi-modal skin atlas identifies a multicellular immune-stromal community associated with disrupted cornification and specific T cell expansion in atopic dermatitis | Nature Communications

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By Evgenij Fiskin, Gökcen Eraslan, Tanvi Jain, Juan Manuel Leyva-Castillo, Sean Kim, Caleb A Lareau, Helena Lau, Emily Finan, Brenna LaBere, Anne H.Y. Chu, Brian Woods, Janet Chou, Michal Slyper, Julia Waldman, Sabina Islam, Lynda Schneider, Wanda Phipatanakul, Craig Platt Verified, Orit Rozenblatt-Rosen, Toni Delorey, Orr Ashenberg, Jacques Deguine, Gideon Smith, Raif S. Geha, Aviv Regev, Ramnik Xavier, Maria B. Alora-Palli, Heather Choe, Isabella Teixeira-Soldano
| Nature Verified
Abstract In atopic dermatitis (AD), skin barrier and immune dysfunction result in chronic tissue inflammation, yet our understanding of the tissue ecosystem remains incomplete. Here, we generate a multi-modal census of 280,518 cells from whole skin tissue samples from 17 adults, including 11 AD patients, integrating it with 430,186 cell profiles from four previous studies into a comprehensive human skin cell atlas.
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