Tanwen Wu on Muck Rack

Tanwen Wu

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Articles

Epithelial plasticity shapes intratumoral heterogeneity and cell lineages in early-stage lung cancer

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By Yu Xiao, Yatian Chen, Yoshihiro Okamura, Xiaofang Wang, Kai Yan, Ning Xin, Weiqing Li, Zhengwei Zhang, Chunling Zeng, Yuxiang Luo, Xiaoxiao Liu, Xiaojing Lu, Yue Dong, Xu Lin, Ying Li, Xiaona Jia, Simin Wang, Hua Tang, Yuexiang Wang, Yangjie Xiong, Yumei Cheng, Xinhui Yan, Haoqi Lan, Tanwen Wu
| Science Magazine Verified
Abstract Intratumoral heterogeneity (ITH) has been investigated primarily in locally advanced or metastatic cancer; however, much less is known about ITH in early-stage cancer, and the origins of ITH are poorly understood. Through single-cell and spatial transcriptomics of early-stage ground-glass opacity (GGO)–like lung adenocarcinoma (LUAD) (14 patients; 103,375 cells), we systematically define tumor states and demonstrate that pervasive transcriptional ITH exists in early-stage LUAD.
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