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Tchelet Goldberg

As seen in: Cell Press
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Hypertranscription caused by p53 deficiency triggers nucleotide insufficiency that induces replication stress and genomic instability

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By Wisam Zaatra, George Philippos, Petr Smirnov, Shira Milo, Michelle Chan Verified, Michal Harel, Frauke Devens, Tchelet Goldberg, Alexandra Eliassaf, Karen Grimes, Michal Irony-Tur, Gianluca Sigismondo, Kathrin Laue, Uri Ben-David, Tamar Geiger, Jan Korbel, Jeroen Krijgsveld, Ori Shalev, Aurélie Ernst, Batsheva Kerem
| Cell Press Verified
Keywords hypertranscription p53 deficiency replication stress nucleotide insufficiency chromothripsis genomic instability cancer Introduction Genomic instability is a hallmark and a driving force of cancer development. It increases the likelihood of point mutations and genomic rearrangements, such as deletions, amplifications, translocations and insertions.
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