Tencho Tenev

Abstract Necroptosis initiated by the host sensor Z-NA Binding Protein-1 (ZBP1) is essential for host defense against a growing number of viruses, including Herpes Simplex Virus-1 (HSV-1). Studies with HSV-1 and other necroptogenic stimuli in murine settings have suggested that ZBP1 triggers necroptosis by directly complexing with the kinase RIPK3. Whether this is also the case in human cells, or whether additional co-factors are needed for ZBP1-mediated necroptosis, is unclear.

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MIB2 Is a Constituent of the Native TNF-RSC   MIB2 Conjugates Different Types of Ub Chains to RIPK1 Given that MIB2 did not modulate TNF-induced activation of NF-κB in the cell lines tested, we explored the role of this E3 ligase in regulating TNF-induced and RIPK1-dependent cell death. We tested a range of different cell lines that exhibit diverse sensitivities to TNF-induced cell death (Figures S2x Download (8.56 MB ) Document S1.