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Thamizhanban Manoharan on Muck Rack

Thamizhanban Manoharan

As seen in: Science Magazine
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Articles

Healthy donor T cell receptors expand functional neoantigen recognition beyond patient vaccination

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By Hong Kai Teo, Soham Basu, Alexandre Bouyssou, Shuting Han, Thamizhanban Manoharan, Yi Ren, Zhewang Lin, Jiaqi Li, Si-Lin Koo, Choon Kong Yap, Kai-Yin Lee, Who-Whong Wang, Malini Rethnam, Bei-En Siew, Gwyneth Shook-Ting Soon, Wai-Kit Cheong, Ian Jse-W
| Science Magazine Verified
Abstract A major challenge in advancing neoantigen-targeted therapies lies in the limited capacity of predicted neoantigens to robustly activate CD8+ T cells, emphasizing the critical need for comprehensive functional validation before patient vaccination. Here, we provide a direct comparison of neoantigen-specific T cell responses between vaccinated patients with cancer and HLA-matched healthy donors.
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Circular RNA as a source of neoantigens for cancer vaccines

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By Yi Ren, Thamizhanban Manoharan, Beijia Liu, Bei En Siew
| bmj.com
Clinical samples Healthy donor blood samples were obtained from the Singapore Health Sciences Authority blood bank (Application #202006–06). Human PBMCs were isolated blood samples using Ficoll-Paque (Cytiva, #17144003). The study involved six patients diagnosed with CRC who underwent surgery at National University Hospital. After resection, samples from both tumor and adjacent normal colon tissues were collected and immediately transferred for organoids derivation and DNA/RNA extraction.
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