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Articles

Population-level genomic analysis of immunoglobulin loci variation in rhesus macaques reveals extensive germline diversity

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By Ayelet Peres, Amit Upadhyay, Vered Klein, Swati Saha, Oscar Rodriguez, Oscar Rodríguez Verified, Óscar Rodríguez Verified, Zachary M. Vanwinkle, Kirti A. Karunakaran, Amanda R. Metz, William A. Lauer, Mark Lin, Timothy L. Melton, Lukas Granholm, Pazit Polak, Samuel M. Peterson, Eric Peterson, Nagarajan Raju, Kaitlyn T Shields, Steven R. Schultze, Adam J. Ericsen, Stacey A. Lapp, Francois Villinger, Mats Ohlin, Christopher A. Cottrell, Rama R. Amara, Cynthia A. Derdeyn, Shane Crotty, William R. Schief, Melissa Smith, William Lees, Corey T. Watson, Gur Yaari, Steven E. Bosinger, Thang Ton
| Cell Press Verified
Keywords immunoglobulins rhesus macaque broadly neutralizing antibodies repertoire database genomics germline inference antibodies HIV B cell receptor Introduction The extraordinary diversity of B cell receptors (BCRs) underpins the adaptive immune system’s ability to recognize a vast range of foreign antigens and produce high-affinity, neutralizing antibodies.1 In mammals, BCRs are encoded by an extensive gene family that resides within three immunoglobulin (IG) loci: the heavy-chain locus...
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