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Articles by Theo Bourdais
Extraordinary Tibetan Plateau early-winter heating drove record-breaking winter precipitation in California and adjacent regions
Abstract INTRODUCTION RESULTS DISCUSSION MATERIALS AND METHODS Acknowledgments REFERENCES Information & Authors Metrics & Citations View Options References Figures Tables Media Share This article has 0 eLetter . Abstract California and adjacent regions received record-breaking precipitation in the winters of 2016–2017 and 2022–2023, causing extraordinary damage and severe societal impacts.
Engineering suppressor tRNAs for effective treatment of Duchenne muscular dystrophy
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Abstract INTRODUCTION RESULTS DISCUSSION MATERIALS AND METHODS Acknowledgments Supplementary Materials REFERENCES Information & Authors Metrics & Citations View Options References Figures Tables Media Share This article has 0 eLetter . Abstract Duchenne muscular dystrophy (DMD) is a fatal disorder caused by loss of dystrophin, a protein essential for muscle cell integrity. To date, no therapeutic has restored full-length dystrophin.
By DeNard V Simmons, Dongjun Li, Theo Bourdais, Julien Oury, Ying-Hsin Chen, Sean McFarland, Delilah Jewel, Steffany Villasenor, William Mannheim, Victoria Rose, Sophia Zheng, Michael Calhoun Verified, Nathan Strozewski, Paul Kaplan, Jeff Coller, Harvey F. Lodish, Joel Wen, Teerithveen Pasricha, Alexis Dilts, McKenna Montminy, Nitusingh Thakur, Peter M. Eimon
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Science Magazine
Verified
Gap-closing experimental estimation of quantum Fisher information
Abstract INTRODUCTION RESULTS DISCUSSION MATERIALS AND METHODS Acknowledgments Supplementary Materials REFERENCES Information & Authors Metrics & Citations View Options References Figures Tables Media Share This article has 0 eLetter . Abstract Estimating the quantum Fisher information (QFI) is a central task in quantum science and technology, underpinning the benchmarking of measurement devices and the certification of metrological advantages.
TCR-JANUS engager proteins enable bispecific targeting to overcome tumor heterogeneity in TCR-T cell therapy
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Abstract INTRODUCTION RESULTS DISCUSSION MATERIALS AND METHODS Acknowledgments Supplementary Materials REFERENCES Information & Authors Metrics & Citations View Options References Figures Tables Media Share This article has 0 eLetter . Abstract T cell receptor (TCR)–based immunotherapy is limited by tumor antigen heterogeneity, which frequently leads to relapse. We developed a bispecific TCR-JANUS engager that functions synergistically with TCR engineered T cells (TCR-T).
By DeNard V Simmons, Dongjun Li, Theo Bourdais, Chenxi Cheng, Ting Liang, Pengju Yao, Wenling Wang, Xiaowen Li, Ying Tian Verified, Jie Wang, Danli Xie, Fuming Qiu, Shuguang Tan, Huxuan Chen
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Science Magazine
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Mechanistic trade-offs between local and long-range signaling activity in natural and synthetic morphogens
Abstract INTRODUCTION RESULTS DISCUSSION MATERIALS AND METHODS Acknowledgments Supplementary Materials REFERENCES Information & Authors Metrics & Citations View Options References Figures Tables Media Share This article has 0 eLetter . Abstract Hedgehog family morphogens present an interesting paradox: Despite being hydrophobic because of dual-lipid modifications, they form spatial concentration gradients that are highly conserved and essential for many aspects of metazoan development.
A bimetallic CuBi catalyst for enhanced electrochemical CO reduction to acetate
Abstract INTRODUCTION RESULTS DISCUSSION MATERIALS AND METHODS Acknowledgments Supplementary Materials REFERENCES Information & Authors Metrics & Citations View Options References Figures Tables Media Share This article has 0 eLetter . Abstract Catalyst design principles for generating multicarbon (C2+) products from electrochemical carbon dioxide (CO2) reduction (CO2R) and carbon monoxide (CO) reduction (COR) are often similar and used interchangeably.
GSK3β and Plk1 sequentially phosphorylate ATP–citrate lyase to promote homologous recombination
Abstract INTRODUCTION RESULTS DISCUSSION MATERIALS AND METHODS Acknowledgments Supplementary Materials REFERENCES Information & Authors Metrics & Citations View Options References Figures Tables Media Share This article has 0 eLetter . Abstract Accurate repair of DNA double-strand breaks (DSBs) by homologous recombination (HR) is essential for genome stability.
A highly sensitive and drift-free iontronic sensor enabled by a polarity-balanced polyelectrolyte for surgical force sensing
Abstract INTRODUCTION RESULTS DISCUSSION MATERIALS AND METHODS Acknowledgments Supplementary Materials REFERENCES Information & Authors Metrics & Citations View Options References Figures Tables Media Share This article has 0 eLetter . Abstract Iontronic pressure sensors featuring high sensitivity are promising across different emerging fields.
Substrate heterogeneity promotes cancer cell dissemination through interface roughening
Abstract INTRODUCTION RESULTS DISCUSSION MATERIALS AND METHODS Acknowledgments Supplementary Materials REFERENCES Information & Authors Metrics & Citations View Options References Figures Tables Media Share This article has 0 eLetter . Abstract Although studies of tumor invasion have mainly emphasized the evolution of genetic and epigenetic heterogeneity, cellular behaviors also depend on the physical microenvironment.
A systematic comparison of single-cell perturbation response prediction models
Abstract INTRODUCTION RESULTS DISCUSSION MATERIALS AND METHODS Acknowledgments Supplementary Materials REFERENCES Information & Authors Metrics & Citations View Options References Figures Tables Media Share This article has 0 eLetter . Abstract Predicting single-cell transcriptional responses to perturbations is central to dissecting gene regulation and accelerating therapeutic design, yet the field lacks a rigorous, task-spanning assessment of model behavior.
BCL11B predetermines a persister state in breast cancer that is reversed by TNFα
Abstract INTRODUCTION RESULTS DISCUSSION MATERIALS AND METHODS Acknowledgments Supplementary Materials REFERENCES Information & Authors Metrics & Citations View Options References Figures Tables Media Share This article has 0 eLetter . Abstract The frequent development of chemoresistance in cancer presents a major clinical challenge, yet the underlying causes of heterogeneous drug responses remain largely elusive.
Shedding light on the formation mechanisms of Islamic polychrome lusters: A Cu, Fe, Ag micro XANES study
Abstract INTRODUCTION RESULTS DISCUSSION MATERIALS AND METHODS Acknowledgments Supplementary Materials REFERENCES Information & Authors Metrics & Citations View Options References Figures Tables Media Share This article has 0 eLetter . Abstract Islamic luster is a ceramic glaze decoration exploiting the quantum-confined optical response of noble metallic nanoparticles to produce a colorful metallic and iridescent appearance.
Dysregulated m 6 A via compensatory arginine methylation primes premalignancy in metabolic dysfunction–associated steatotic liver disease
Abstract INTRODUCTION RESULTS DISCUSSION MATERIALS AND METHODS Acknowledgments Supplementary Materials REFERENCES Information & Authors Metrics & Citations View Options References Figures Tables Media Share This article has 0 eLetter .
Early detection of invasive lung cancer and multiorgan metastasis by a collagen-targeted protein MRI contrast agent
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Abstract INTRODUCTION RESULTS DISCUSSION MATERIALS AND METHODS Acknowledgment Supplementary Materials REFERENCES Information & Authors Metrics & Citations View Options References Figures Tables Media Share This article has 0 eLetter . Abstract Lung cancer with multiorgan metastasis remains the leading cause of cancer death. Current CT imaging and biopsy are suboptimal for detecting early tumors or subclinical metastases.
By DeNard V Simmons, Dongjun Li, Theo Bourdais, Jingjuan Qiao, Francis Akinlotan, Xuxin Chen, Yi Yuan, Zongxiang Gui, Eva Toth, Agnès Pallier, Yiting xu, Yusheng Zhang, Xiaofeng Ke, Alton B. Farris, Hua Yang, Jian-xiong Wang, Jennifer W. Carlisle, Suresh S. Ramalingam, Michael Kirberger, Hans E. Grossniklaus, Oluwabukola Bamishaye, Sandi Li, Farzaneh Dorabadizare, Yijan Fan, Khan Hekmatyar
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Science Magazine
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Peroxiredoxin 1 safeguards the nucleolar genome from oxidative damage
Abstract INTRODUCTION RESULTS DISCUSSION MATERIALS AND METHODS Acknowledgments Supplementary Materials REFERENCES Information & Authors Metrics & Citations View Options References Figures Tables Media Share This article has 0 eLetter . Abstract Peroxiredoxin 1 (PRDX1) is a highly conserved, thiol-dependent peroxidase that rapidly scavenges reactive oxygen species to modulate redox signaling.
Environmental filtering shapes patch dynamics across isolated mesophotic reefs
Abstract INTRODUCTION RESULTS DISCUSSION MATERIALS AND METHODS Acknowledgments Supplementary Materials REFERENCES Information & Authors Metrics & Citations View Options References Figures Tables Media Share This article has 0 eLetter . Abstract Mesophotic coral ecosystems (MCEs; ∼30 to 150 meters) are major but poorly understood benthic habitats.
Metabolic regulation of calcium homeostasis via SERCA succination
Abstract INTRODUCTION RESULTS DISCUSSION MATERIALS AND METHODS Acknowledgments Supplementary Materials REFERENCES Information & Authors Metrics & Citations View Options References Figures Tables Media Share This article has 0 eLetter . Abstract Although calcium homeostasis is disrupted in metabolic diseases, its metabolic regulation remains unclear.
Discovering algorithms with computational language processing
Abstract INTRODUCTION RESULTS DISCUSSION MATERIALS AND METHODS Acknowledgments Supplementary Materials REFERENCES Information & Authors Metrics & Citations View Options References Figures Tables Media Share This article has 0 eLetter . Abstract We present a framework automating algorithm discovery by bootstrapping their natural conceptualization as sequences of operations, represented as tokens.
Genomic signatures of adaptation across a landscape of crickets following the introduction of a parasitoid fly
Abstract INTRODUCTION RESULTS DISCUSSION MATERIALS AND METHODS Acknowledgments Supplementary Materials REFERENCES Information & Authors Metrics & Citations View Options References Figures Tables Media Share This article has 0 eLetter . Abstract Novel species interactions provide an opportunity to assess the earliest stages of genetic adaptation.
Magnetically actuated nanoantennas for wireless glioblastoma therapy
Abstract INTRODUCTION RESULTS DISCUSSION MATERIALS AND METHODS Acknowledgments Supplementary Materials REFERENCES Information & Authors Metrics & Citations View Options References Figures Tables Media Share This article has 0 eLetter . Abstract Glioblastoma (GBM) remains a formidable clinical challenge, characterized by invasive growth, therapeutic resistance, and dismal patient survival.
Heterogeneous energy-transfer metallaphotocatalysis unlocks direct and site-selective thioglycosylation of unprotected thiosugars
Abstract INTRODUCTION RESULTS DISCUSSION MATERIALS AND METHODS Acknowledgments Supplementary Materials REFERENCES Information & Authors Metrics & Citations View Options References Figures Tables Media Share This article has 0 eLetter . Abstract The creation of glycoconjugates, particularly well-defined glycopeptides, is crucial for advancing biological research and therapeutic development.
Chirality-induced magnetoresistance in hybrid organic-inorganic perovskite semiconductors
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Abstract INTRODUCTION RESULTS DISCUSSION MATERIALS AND METHODS Acknowledgments Supplementary Materials REFERENCES Information & Authors Metrics & Citations View Options References Figures Tables Media Share This article has 0 eLetter .
By DeNard V Simmons, Dongjun Li, Theo Bourdais, Azimul Haque, Pius M. Theiler, Ian Leahy, Steven P. Harvey, Jeiwan Tan, Matthew P. Hautzinger, Margherita Taddei, Aeron McConnell, Andrew Grieder, Andrew Comstock, Yifan Dong, Kirstin Alberi, Yuan Ping, Peter C. Sercel, Joseph Luther, Dali Sun, Matthew Beard
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Science Magazine
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Spatiotemporal mapping of tertiary lymphoid structure heterogeneity shapes immune niches and clinical outcomes in intrahepatic cholangiocarcinoma
Abstract INTRODUCTION RESULTS DISCUSSION MATERIALS AND METHODS Acknowledgments Supplementary Materials REFERENCES Information & Authors Metrics & Citations View Options References Figures Tables Media Share This article has 0 eLetter . Abstract Intrahepatic cholangiocarcinoma (iCCA) is a highly lethal malignancy with limited therapeutic options. The spatial architecture and functional diversity of tertiary lymphoid structures (TLSs) in iCCA remain unclear.
Three-dimensional reconfigurable magnetic microswarms with boundary-transcending capabilities
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Abstract INTRODUCTION RESULTS DISCUSSION MATERIALS AND METHODS Acknowledgments Supplementary Materials REFERENCES Information & Authors Metrics & Citations View Options References Figures Tables Media Share This article has 0 eLetter . Abstract Swarm behaviors are prevalent in nature and have inspired many engineering designs.
By DeNard V Simmons, Dongjun Li, Theo Bourdais, Pengsong Zhang, PengFei Xu, Peng Pan, Yuntong Sun, Shaojia Wang, Runze Zuo, Chongyu Zhang, Wentian Tang, Tiancong Wang, Yuhang Wang, Mingzhe Sun, Qiwu Zhang, Yuxiao Zhou, Yunkai Wang, Junhui Law, Wenkun Dou, Juntian Qu, Ren-Ke Li, Yu Sun, Xinyu Liu, Junyue Dai
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Science Magazine
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Self-stretching molecular monolayers with autonomous folding and mechanical adaptation
Abstract INTRODUCTION RESULTS DISCUSSION MATERIALS AND METHODS Acknowledgments Supplementary Materials REFERENCES Information & Authors Metrics & Citations View Options References Figures Tables Media Share This article has 0 eLetter . Abstract Molecular monolayers at fluid interfaces are generally considered mechanically fragile, collapsing under lateral compression.
The CENP-A chaperone complex spatially organizes centromeres
Abstract INTRODUCTION RESULTS DISCUSSION MATERIALS AND METHODS Acknowledgments Supplementary Materials REFERENCES Information & Authors Metrics & Citations View Options References Figures Tables Media Share This article has 0 eLetter . Abstract Centromeres, defined by CENP-A–containing nucleosomes, direct kinetochore assembly for spindle attachment.
Betel nut sucking is the earliest recorded evidence for the habitual use of a neuroactive plant drug
Abstract INTRODUCTION RESULTS DISCUSSION MATERIALS AND METHODS Acknowledgments Supplementary Materials REFERENCES Information & Authors Metrics & Citations View Options References Figures Tables Media Share This article has 0 eLetter . Abstract The modern custom of chewing betel nuts is practiced by around 1 in 10 people worldwide, yet the earliest beginnings of this widespread drug use habit are unknown.
Multiproxy bioarchaeological analyses reveal subsistence shift in Bronze Age Central Europe
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Abstract INTRODUCTION RESULTS DISCUSSION MATERIALS AND METHODS Acknowledgments Supplementary Materials REFERENCES Information & Authors Metrics & Citations View Options References Figures Tables Media Share This article has 0 eLetter . Abstract Changes in past subsistence strategies reflect the adaptation of human societies to climatic, environmental, and cultural settings.
By DeNard V Simmons, Dongjun Li, Theo Bourdais, Margaux L. C. Depaermentier, Przemysław Makarowicz, Anita Szczepanek, Christophe Snoeck, Marine Morvan, Zdzislaw Belka, Michael Kempf, Maciej Chyleński, Jacek Górski, Tomasz Goslar, Ryszard Grygiel, Paweł Jarosz, Anna Juras, Marek Nowak, Marcin Przybyła, Piotr Włodarczak, Jarosław Wilczyński, Halina Taras, Anna Lasota-Kuś, Andrzej Matoga, Krzysztof Tunia, Irena Wójcik
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Science Magazine
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A direct protein bridge connects the ds and ds-ss junction telomeric DNA segments in C. elegans
Abstract INTRODUCTION RESULTS DISCUSSION MATERIALS AND METHODS Acknowledgments Supplementary Materials REFERENCES Information & Authors Metrics & Citations View Options References Figures Tables Media Share This article has 0 eLetter . Abstract The six-protein shelterin complex safeguards mammalian chromosome ends; however, its intricate protein-protein and protein-DNA interactions complicate biochemical dissection. The C.
The Media Bias Detector: A framework for annotating and analyzing the news
Abstract INTRODUCTION MATERIALS AND METHODS RESULTS DISCUSSION Acknowledgments Supplementary Materials REFERENCES Information & Authors Metrics & Citations View Options References Figures Tables Media Share This article has 0 eLetter . Abstract News organizations introduce bias into their coverage via the choices they make about which topics to cover (or ignore) and how to frame the issues they do decide to cover.
Astrocytes mediate the dopaminergic modulation of tonic GABAergic signaling in substantia nigra
Abstract INTRODUCTION RESULTS DISCUSSION MATERIALS AND METHODS Acknowledgments Supplementary Materials REFERENCES Information & Authors Metrics & Citations View Options References Figures Tables Media Share This article has 0 eLetter . Abstract Recent studies have implicated dopaminergic signaling within the substantia nigra pars reticulata (SNr) in the emergence of Parkinsonian motor deficits.
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