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Articles by Timothy Murphy
Real-time closed-loop feedback system for mouse mesoscale cortical signal and movement control
eLife Assessment This study presents a platform to implement closed-loop experiments in mice based on auditory feedback. The authors provide convincing evidence that their platform enables a variety of closed-loop experiments using neural or movement signals, indicating that it will be a valuable resource to the neuroscience community. The authors make this platform more accessible by complementing the paper with a detailed tutorial explaining how to implement the software and hardware.
Massachusetts Health Policy Commission Proposes Significant Expansion of Private Equity Reporting Requirements for Provider Organizations—Comments Due September 24
On September 9, 2026, the Massachusetts Health Policy Commission (HPC) and the Center for Health Information and Analysis (CHIA) released for public comment proposed updates (the “Proposed Updates”) to the reporting requirements of the Massachusetts Registration of Provider Organizations Program (the “MA-RPO Program”).
How does AI detect diabetic retinopathy from retinal photos? A heatmap analysis of 54 deep learning models
The authors have declared no competing interest. I confirm all relevant ethical guidelines have been followed, and any necessary IRB and/or ethics committee approvals have been obtained.
Policies That Allow More Homebuilding Can Help Older Adults
More than 7 in 10 older adults would prefer to remain in their communities as they age, while large majorities of those 50 and older favor a roster of zoning and land use policies that would allow more homes to be built, according to surveys by AARP and The Pew Charitable Trusts. The United States is aging. The share of those 65 and older increased 34% between 2012 and 2022, reaching 58 million people. By 2030, 1 in 5 Americans will be at least 65.
Decoding state-dependent cortical-cerebellar cellular functional connectivity in the mouse brain
Highlights • Cerebellar activity is correlated with multiple cortical patterns • Cortico-cerebellar functional connectivity is dynamic across behavioral states • Complex spikes preferably associate with sensorimotor cortical activity • Resting-state functional connectivity reflect neurons’ response to sensory stimuli Summary The cortex and cerebellum form multi-synaptic reciprocal connections.
BC Government Consulting On New Law To Give Indigenous Groups Control Over Crown Land Decisions
Earlier this month the BC Government posted (without any media release) a topic "Land Act Amendments" on a little-known website www.engage.gov.bc.ca. The "Land Act Amendments" item shows a pleasing photo of an alpine meadow and is listed among other consultations related to matters such as "Specialty Licence Plates Program Expansion" and "Reimagining the Royal BC Museum".
Programmatically Localizing Diabetic Retinopathy Features in 45-Degree Retinal Photographs Using Anatomical Colocation
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Mesotrode chronic simultaneous mesoscale cortical imaging and subcortical or peripheral nerve spiking activity recording in mice
eLife assessment This valuable study combines chronic widefield calcium imaging of dorsal cortex activity at the mesoscale level with electrical recording of single neurons in specific cortical and subcortical locations. This work provides compelling evidence for recording neuronal activity at multiple temporal and spatial scales by combination of optical and electrophysiological methods. This work will be of broad interest to system neuroscientists studying neural circuits.
Is your supply chain trustworthy?
Action 2: Make visibility into sustainability a priority Transparency is foundational to trust and, by close extension, performance.
PyMouseTracks: Flexible Computer Vision and RFID-Based System for Multiple Mouse Tracking and Behavioral Assessment
Abstract PyMouseTracks (PMT) is a scalable and customizable computer vision and radio frequency identification (RFID)-based system for multiple rodent tracking and behavior assessment that can be set up within minutes in any user-defined arena at minimal cost. PMT is composed of the online Raspberry Pi (RPi)-based video and RFID acquisition with subsequent offline analysis tools. The system is capable of tracking up to six mice in experiments ranging from minutes to days.
Mesotrode: chronic simultaneous mesoscale cortical imaging and subcortical or peripheral nerve spiking activity recording in mice.
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Coalition Questions New Jail Plan
Allen County leadership is still failing the community with their recent plans to proceed with building the most expensive public project in county history, only in a less obnoxious place. There are several reasons why this insistence on a new jail is ill-informed, morally wrong and harmful to our community.
Mastercard Supports The National Urban League to Preserve U.S. Civil Rights
The National Urban League’s 2022 conference, which took place in our nation’s capital last week as the first in-person since the pandemic started, was energizing, impactful and insightful. I was joined by my extraordinary colleagues from Mastercard, NUL leaders and staff, policymakers and business and community leaders, all of whom came together to engage in meaningful dialogue and chart out pathways to create greater opportunity for Black and indeed all Americans.
Cannabinoid Content and Label Accuracy of Hemp-Derived Topical Products
Key Points Question Are hemp-derived topical cannabinoid products available online and at national retailers accurately labeled for cannabidiol (CBD) and Δ9-tetrahydrocannabinol (THC) content?
How Unions Fared in 2020 – Signs from Recent U.S. Bureau of Labor Statistics Poll - HR Daily Advisor
Whenever there’s a change in the political party at the White House, we usually see a shift in policy at the National Labor Relations Board (NLRB), too. This year is unique because, in addition to the change in leadership, we are slowly emerging from more than a year of uncertainty caused by the COVID-19 pandemic. Given the changes, we thought it might be time to look back on how unions did in 2020 and what might be coming.
Multidisciplinary discovery of ancient restoration using a rare mud carapace on a mummified individual from late New Kingdom Egypt
Loading metrics Open Access Peer-reviewed Research Article Karin Sowada , Ronika K. Power, Geraldine Jacobsen, Timothy Murphy, Alice McClymont, Fiona Bertuch, Andrew Jenkinson, Jacinta Carruthers, John Magnussen Karin Sowada, Ronika K.
Supervised Exercise, Stent Revascularization, or Medical Therapy for Claudication Due to Aortoiliac Peripheral Artery Disease
Journal of the American College of Cardiology Original Investigation Timothy P. Murphy, Donald E. Cutlip, Judith G. Regensteiner, Emile R. Mohler III, David J. Cohen, Matthew R. Reynolds, Joseph M. Massaro, Beth A. Lewis, Joselyn Cerezo, Niki C. Oldenburg, Claudia C. Thum, Michael R. Jaff, Anthony J. Comerota, Michael W. Steffes, Ingrid H. Abrahamsen, Suzanne Goldberg and Alan T. Hirsch Author + information Timothy P. Murphy, MD∗∗ (tmurphy{at}lifespan.org), Donald E. Cutlip, MD†,‡, Judith G.
Daily Legal News
Common Pleas Workers' Comp Date Filed July 24, 2020 Case Number 935201 Case Type Workers' Comp Judge Judge S. Saffold Plaintiff Filed by. Timothy Murphy 31300 Solon Rd., Ste. 12 Solon, OH 44139 Plaintiff's Attorney The Goldberg Law Firm Co., LPA 31300 Solon Road Solon OH 44139 Defendant Relmec Mechanical, LLC, et al. 4975 Hamilton Ave. Cleveland, OH 44114 About your information and the public record.
Automated task training and longitudinal monitoring of mouse mesoscale cortical circuits using home cages
Abstract We report improved automated open-source methodology for head-fixed mesoscale cortical imaging and/or behavioral training of home cage mice using Raspberry Pi-based hardware. Staged partial and probabilistic restraint allows mice to adjust to self-initiated headfixation over 3 weeks’ time with ~50% participation rate. We support a cue-based behavioral licking task monitored by a capacitive touch-sensor water spout.
Gratitude In the Age of COVID-19
I’ve been thinking a lot about what I am actually feeling these days. It’s a confusing and unsettling time. A few weeks ago I know what I was feeling: overwhelmed. The first moments of the coronavirus pandemic were all crisis management, all the time. The boundary between work and home had blurred, so every waking moment felt like work. The issues were new, and hard. Family, friends and colleagues all needed support. It was an awful lot to take on all at once.
Real-Time Selective Markerless Tracking of Forepaws of Head Fixed Mice Using Deep Neural Networks
Research ArticleResearch Article: Methods/New Tools, Novel Tools and Methods Brandon J. Forys, Dongsheng Xiao, Pankaj Gupta and Timothy H. Murphy eNeuro 14 May 2020, 7 (3) ENEURO.0096-20.2020; DOI: https://doi.org/10.1523/ENEURO.0096-20.2020 Abstract Here, we describe a system capable of tracking specific mouse paw movements at high frame rates (70.17 Hz) with a high level of accuracy (mean=0.95, SD<0.01).
Social distancing saves lives
By TIMOTHY F. MURPHY Last week I had multiple conversations with people who asked, “Why are we taking such drastic measures when there aren’t even any coronavirus infections in Western New York?” The dominoes fell quickly soon after, with SUNY classes going online, innumerable events that involve crowds being canceled, the entire sports world grinding to a halt and inevitable school closings. These are unprecedented times with the COVID-19 global pandemic that is affecting our community.
Coronavirus - A Preparedness And Response Guide For Canadian Businesses - Corporate/Commercial Law - Canada
To print this article, all you need is to be registered or login on Mondaq.com. Coronavirus (COVID-19) has sent shock waves through global markets, businesses and supply chains. Boards of directors and senior management of businesses are likely asking themselves some tough questions. For instance: 1. What should we be doing to protect our employees and operations? 2. Can boards be responsible if employees get sick from COVID-19? 3.
Coronavirus - A Preparedness and Response Guide for Canadian Businesses | Lexology
Coronavirus (COVID-19) has sent shock waves through global markets, businesses and supply chains. Boards of directors and senior management of businesses are likely asking themselves some tough questions. For instance: 1. What should we be doing to protect our employees and operations? 2. Can boards be responsible if employees get sick from COVID-19? 3. Do we really understand the risks to our business operations from COVID-19? 4.
Cortex-wide Computations in Complex Decision Making in Mice
Seemingly, a paradox exists between reports of wide-scale task-dependent cortical activity and the causal requirement for only a restricted number of motor and sensory cortical areas in some behavioral studies. In this issue of Neuron,indicate that scenarios where mice must accumulate evidence and hold it during a delay period are causally linked to wide regions of cortex.
Final Two-Year Outcomes for the Sentry Bioconvertible Inferior Vena Cava Filter in Patients Requiring Temporary Protection from Pulmonary Embolism
In appropriately chosen patients, systematic reviews and meta-analyses have shown that inferior vena cava (IVC) filters are effective at providing mechanical protection against pulmonary embolism (PE) (1x1Angel, L.F., Tapson, V., Galgon, R.E., Restrepo, M.I., and Kaufman, J. Systematic review of the use of retrievable inferior vena cava filters. J Vasc Interv Radiol. 2011; 22: 1522–1530 e1523 Google ScholarSee all References, 2x2Bikdeli, B., Chatterjee, S., Desai, N.R. et al.
How nudge theory and design thinking can help your government IT project succeed
Technology adoption is ultimately about human behavior. Learn how organizations can use a "people-first" approach and infuse behavioral insights into the mix to improve outcomes. The promise—and the reality—of tech adoption Technology makes our lives better. Except when it doesn’t. Of course, these technologies need to offer an improvement in their own right. This is especially true of new digital technologies that are introduced into our lives—or workplaces—and don’t stick.
City must reckon with its namesake's history | Columns | Journal Gazette
Shelly Murphy Tuesday, July 16, 2019 1:00 am Misty-Dawn Shelly and Timothy C. Murphy The passing of a resolution from City Councilman Jason Arp earlier this year makes today, July 16, the first Anthony Wayne Day in recognition of Fort Wayne's namesake. However, we believe this resolution overlooks the fact that Fort Wayne sits on the ancestral lands of the Miami people.
Brief History of a Recurring Nightmare
WHEN the American Psychiatric Association drew up its list of disorders in 1952, it described homosexuality as a sociopathic personality disorder. Many therapists were far ahead of that formality: they were already trying to cure homosexual men and women and prevent homosexuality from taking hold in children. Since the late 1800’s, psychiatrists, psychologists, endocrinologists, and others have investigated treatments for homosexuality.
Future in the balance? How countries are pursuing an AI advantage
Companies around the globe, boosted by countries’ various strategies, have worked to implement AI practices. Our survey suggests what early adopters have learned—and how leaders can learn from their AI experiences. With leaders increasingly seeing artificial intelligence (AI) as helping to drive the next great economic expansion, a fear of missing out is spreading around the globe.
Why U.S. forces must remain in Syria until the facts on the ground show otherwise
ANALYSIS/OPINION: We need to stay in Syria, and it has very little to do with ISIS. In many ways, President Trump’s foreign policy in the Middle East and Afghanistan is admirable. He is attempting to end the “endless” wars in Afghanistan, Iraq, and now Syria. He wants to make a clean break with his predecessors who he believes embroiled the nation in conflicts where the United States had limited control over success or failure.
Participatory design in the age of artificial intelligence
As expectations around artificial intelligence grow, organizations will have to bring human thinking into their products. To do so, it is imperative that communities that will be part of the solution actively participate in the product design as well. Business aspirations for artificial intelligence (AI) are at an all-time high.
Differential distribution of IgA-protease genotypes in mucosal and invasive isolates of Haemophilus influenzae in Sweden
In Sweden, the distribution of iga genotypes in H. influenzae was surprisingly consistent with the distribution described in the prior study performed on selected cohorts [11], as more than 40% of isolates from consecutive respiratory tract isolates were positive in the igaB gene screening. There was no significant association between the presence of the igaB gene and type of respiratory tract infection.
Compliance challenges in public sector programs
Noncompliance among citizens can cost government agencies billions of dollars and prevent goals from being achieved. Learn how policymakers can use behavioral science lessons to redesign programs and improve outcomes. What are the biggest challenges facing government? Bureaucracy? Gridlock? A shrinking pool of resources? Chances are compliance—when people act in accordance with preset rules, policies, and/or expectations—doesn’t top the list for many. Yet maybe it should.
One-Year Analysis of the Prospective Multicenter SENTRY Clinical Trial: Safety and Effectiveness of the Novate Sentry Bioconvertible Inferior Vena Cava Filter - Journal of Vascular and Interventional Radiology
In the present imaging-intense IDE trial of the Sentry bioconvertible IVC filter, the composite primary end point of clinical success at 6 months was achieved in 97.4% of evaluable patients (111/114), with the 92.5% lower limit of the 95% CI surpassing the 80% SIR trial performance objective.
Lower Airway Bacterial Colonization Patterns and Species-Specific Interactions in Chronic Obstructive Pulmonary Disease
ABSTRACTLittle is known about interactions between nontypeable Haemophilus influenzae, Moraxella catarrhalis, Streptococcus pneumoniae, and Pseudomonas aeruginosa in the lower respiratory tract in chronic obstructive pulmonary disease (COPD) patients. We characterized colonization by these four bacterial species, determined species-specific interactions, and estimated the effects of host factors on bacterial colonization among COPD patients.
The Art of Nudging Technology Adoption in Government
The U.S. Forest Service recently spent thousands of dollars apiece updating its field radios. The new devices, which could store more frequencies and were easier to program, were intended to improve the firefighter experience. But some veteran wildland firefighters grumbled, pawned the new radios off on rookies, and continued to use the old ones. The problem was that in the new design the volume and channel dials had swapped places, and they didn't like it.
Massachusetts Court Green-Lights Nurses' Defamation Claims
Even in times of relative calm, employers sometimes feel that every personnel decision carries the risk of legal liability. Of course, in times of crisis, an employer must often act decisively to protect its business and its reputation. The following case is a cautionary tale about decisive action and one type of legal risk: defamation claims.
Bringing government and technology together using behavioral economics
Technology adoption is ultimately about human behavior. Learn how organizations can use a "people-first" approach and infuse behavioral insights into the mix to improve outcomes. The promise—and the reality—of tech adoption Technology makes our lives better. Except when it doesn’t. Of course, these technologies need to offer an improvement in their own right. This is especially true of new digital technologies that are introduced into our lives—or workplaces—and don’t stick.
Redefining the role of the CMO
In the three decades since it earned a place in the C-suite, marketing has changed fundamentally. Is it time to redefine the CMO role? The middle of the 19th century marked the dawn of the “physician scientist.” But new ideas weren’t always welcomed, as Dr. Ignaz Semmelweis learned when he declared: “Wash your hands.” Semmelweis had been charged with analyzing the practices of two maternity wards, one managed by physicians, the other by midwives.
Good Vibrations: Resting-State Functional Connectivity Reflects Entrainment of Vasomotion
To use the Enhanced view of this article, please enable JavaScript on in your browser and refresh the page. PreviewGood Vibrations: Resting-State Functional Connectivity Reflects Entrainment of Vasomotion Allen W. ChanxAllen W.
Independent View: Immigrant protection is right for SK
As the Trump administration moves forward with its ill-advised effort to deport millions of undocumented immigrants, it’s trying to compel local police departments, such as ours in South Kingstown, to help.This is a bad idea. Enforcing immigration laws is a federal responsibility, not a local one.
Earned Sick Time Law: Do Unions in Massachusetts Have to Comply? - HR Daily Advisor
After Massachusetts voters approved the Earned Sick Time Law (ESTL) referendum in 2014, a group of construction industry employers filed a lawsuit asking a federal judge to declare that the new law couldn’t be enforced against them because they are parties to collective bargaining agreements (CBAs) with unions. So far, the courts have replied that it’s too early to weigh in one way or the other.
Applying nudge thinking for better outcomes
?Government agencies charged with handling small offenses and oversights can look to a largely untapped resource: the behavioral economics playbook. Learn how “nudges,” if executed effectively, can often yield better results using fewer resources than traditional approaches would. Introduction The idea is simple: It is better for state and local governments to help citizens “do the right thing” in the first place than to go through the painful process of penalizing those who misbehave.
Behavioral principles for delivering effective feedback
Having a workplace environment in which feedback is given and received productively is critical to performance, but it can be difficult to cultivate that culture. Here's how behavioral tactics can help managers avoid missteps and deliver more effective feedback. Introduction In 2001, theatergoers flocked to see a movie that would eventually generate more than $550 million. It was about a 30-year-old accountant who is disillusioned by his job and life.
Timothy S. Murphy - Richmond Times-Dispatch: On The Move
Timothy S. Murphy Posted: Monday, August 15, 2016 12:00 am Timothy S. Murphy Virginia Commonwealth Bank is pleased to announce that Timothy S. Murphy has joined the Bank's Commercial Banking Group as Senior Vice President/Commercial Banker. Tim is a very experienced Commercial Banker and brings a wealth of expertise in financing professional practices and commercial real estate. Tim is a Richmond native and a graduate of the College of William & Mary.
Clarifying Recent Press Release Claims
We want to take a moment to respond and reflect on the recent press release issued by a U.S.-based law firm concerning a proposed UK consumer class action lawsuit. While a lawsuit has not yet been filed, we firmly disagree with the claims as outlined in their press release. First, the European Commission decision they highlight in their press release applied to interchange fees related to transactions that cross borders within the EU.
Loving the one you’re with: How behavioral factors influence responses to customer rewards and incentives
“The first year I started purchasing from them, they sent me a plastic coffee mug during the holiday season. A year later, they sent me a stainless steel mug. I wondered if that meant I had been a better customer that year, or maybe they just decided to upgrade their mugs. Since then, I haven’t received anything.
ER bottleneck punishes mental health patients
As a psychiatrist serving the community of Fallbrook for 30 years, I have often had to direct my patients in crisis to their nearest emergency room for lifesaving care — sometimes voluntarily, and sometimes with the assistance of local law enforcement and paramedics.Indeed, until its closure in 2014, these patients often arrived at Fallbrook Hospital, where I assisted emergency physicians as a consulting psychiatrist.
What’s Behind Gender Panic in the Restroom?
North Carolina recently adopted a statute that requires people to use public restrooms consistent with the sex assigned to them at birth, and other jurisdictions are debating similar proposals. Legislators in Kansas have proposed a bill that would require financial compensation to people who encounter people using restrooms that do not reflect the sex assigned to them at birth. To avoid those outlays, the operators of those restrooms and locker rooms will have to monitor the premises closely.
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