Travis Moore
Phoenix
As seen in:
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The Washington Post,
IGN,
Chron,
Newsday,
BioRxiv,
Cell Press,
Knight Foundation,
Lawfare,
The Journal of Clinical Investigation
and
I try to be a pretty laid-back person, not sure how well that works | Husband to an Awesome Wife | Kentuckian | 3x140.6 5x70.3
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Articles by Travis Moore
Glycosphingolipids regulate phosphatidylserine transport machinery that operates at ER-PM contact sites
Abstract Plasma membrane (PM) localization of KRAS requires specific glycosphingolipids in the outer leaflet and phosphatidylserine (PS) in the inner leaflet. PM PS content is controlled by lipid transport proteins ORP5 and ORP8, which operate at ER-PM membrane contact sites (MCSs).
Systems science methods reveal and address links between discrimination and health disparities in US food systems - Nature Food
Discriminatory practices are well documented and deeply rooted in food systems. Systems science methods such as social network analysis, system dynamics modelling and agent-based modelling can help to determine how discriminatory processes arise, interact and accumulate to contribute to diet-related health disparities. Such methodological approaches can reveal leverage points for advancing equity-driven solutions.
Cell free RNA detection of pancreatic cancer in pre diagnostic high risk and symptomatic patients - Nature Communications
Abstract Pancreatic ductal adenocarcinomas (PDAC) are among the most fatal cancers, in part due to frequent detection at advanced stages. Endoscopic ultrasound-guided fine-needle aspiration (EUS-FNA), the most sensitive diagnostic method of PDAC in current standard clinical practice, is invasive, costly, with access limited to major healthcare settings.
Neuraminidase 1 secondary deficiency contributes to CNS pathology in neurological mucopolysaccharidoses via brain protein hypersialylation
Abstract Mucopolysaccharidoses (MPS) are lysosomal storage diseases caused by defects in catabolism of glycosaminoglycans. MPS I, II, III, and VII, which are associated with lysosomal accumulation of heparan sulphate (HS), manifest with neurological deterioration and currently lack effective treatments.
Multiomic profiling of hypoxic glioblastoma stem cells reveals expansion of subpopulations with distinct epigenetic and CNV profiles
Abstract Glioblastoma is characterized by extensive intratumoral heterogeneity driven by dynamic microenvironmental cues such as hypoxia. While transcriptional and epigenetic variability have been separately linked to hypoxia responses, the integrated impact of hypoxia on gene regulation and clonal architecture in glioblastoma stem cells (GSCs) remains poorly defined.
Background color matching influences sexual behavior, growth, and mortality rate in an African cichlid fish
Abstract Phenotypic plasticity allows organisms to adapt to changing environments within their lifetimes. The cost of plastic adaptations may constrain the persistence of plasticity over evolutionary time. One potential cost is the possibility that phenotypic adjustment to specific environments can cause correlated responses that are not necessarily adaptive.
Mitochondrial permeability transition dictates mitochondrial maturation upon switch in cellular identity of hematopoietic precursors - Communications Biology
Abstract The mitochondrial permeability transition pore (mPTP) is a supramolecular channel that regulates exchange of solutes across cristae membranes, with executive roles in mitochondrial function and cell death. The contribution of the mPTP to normal physiology remains debated, although evidence implicates the mPTP in mitochondrial inner membrane remodeling in differentiating progenitor cells.
Secondary deficiency of neuraminidase 1 contributes to CNS pathology in neurological mucopolysaccharidoses via hypersialylation of brain glycoproteins
Abstract Mucopolysaccharidoses (MPS) are lysosomal storage diseases caused by defects in catabolism of glycosaminoglycans. MPS I, II, III and VII are associated with lysosomal accumulation of heparan sulphate and manifest with neurological deterioration. Most of these neurological MPS currently lack effective treatments.
Publisher Correction: NDUFS4 regulates cristae remodeling in diabetic kidney disease - Nature Communications
Correction to: Nature Communications https://doi.org/10.1038/s41467-024-46366-w, published online 04 March 2024 In the original version of this Article, two asterisks were mistakenly introduced in Fig 1g. This has been corrected in both the PDF and HTML versions of the Article.
NDUFS4 regulates cristae remodeling in diabetic kidney disease - Nature Communications
Abstract The mitochondrial electron transport chain (ETC) is a highly adaptive process to meet metabolic demands of the cell, and its dysregulation has been associated with diverse clinical pathologies. However, the role and nature of impaired ETC in kidney diseases remains poorly understood.
Intracellular Lactate Dynamics Reveal the Metabolic Diversity of Drosophila Glutamatergic Neurons
Abstract Lactate, an intermediary between glycolysis and mitochondrial oxidative phosphorylation, reflects the metabolic state of neurons. Here, we utilized a genetically-encoded lactate FRET biosensor to uncover subpopulations of distinct metabolic states among Drosophila glutamatergic neurons. Neurons within specific subpopulations exhibited correlated lactate flux patterns that stemmed from inherent cellular properties rather than neuronal interconnectivity.
Robust CNV detection using single-cell ATAC-seq
Abstract Copy number variation (CNV) is a widely studied type of structural variation seen in the genomes of cancerous and other dysfunctional cells. CNVs can have direct and indirect effects on gene dosage, and are thought to drive cancer progression and other disorders. Advancements in single-cell assays such as sc-ATAC-seq and sc-RNA-seq, along with their ubiquitous use, allows for the identification of CNVs at single cell resolution.
Meet The First Nurse Hired To Work For Indeed.com
In this episode of the Ask Nurse Alice podcast, Nurse Alice sits down with Dr. Travis Moore, also known as The Indeed Nurse. In his interview, he discusses what his role at Indeed.com entails, his passion for helping people find jobs within the healthcare industry, and the versatility that nurses possess to make an impact beyond bedside nursing. >>Listen to this episode on the Ask Nurse Alice podcast Dr. Moore started off as an EMT and paramedic before becoming a registered nurse.
Why 2023 could be a year for civic-tech optimism
This year has the potential to be a positive, transformational year for government at all levels. You’d be forgiven for scoffing at that sentence. With a divided Congress, many are ready to call 2023 a wash and set their sights on 2024. But from our vantage point in the world of public interest technology, that would be a mistake. We’ve never been as poised to drive meaningful, lasting change in government.
Recruiting for the Congressional Innovation Scholars Program — TechCongress
We’re thrilled to announce that between now and March 15, 2020, we are recruiting for our 2020 Congressional Innovation Scholars program! We’re looking for between six and eight technologists to build the 2020 class— our largest cohort yet. If you’ve recently finished, or are on the cusp of finishing a technical degree program, we hope you’ll apply. We launched the Congressional Innovation Scholars program in 2018 in response to overwhelming interest from students and faculty.
American Crime Journal |
Throughout my coverage of Karlie Guse’s disappearance, I have encountered questioning, skepticism, disbelief, and pushback. That’s fine with me, I’m a sturdy guy and I can back everything up with documented facts. I encourage healthy skepticism – question everything, especially when it involves reporting. Here at ACJ, we’ve been keeping an eye on other published information regarding Karlie – as we have done and will continue to do.
American Crime Journal |
Throughout my coverage of Karlie Guse’s disappearance, I have encountered questioning, skepticism, disbelief, and pushback. That’s fine with me, I’m a sturdy guy and I can back everything up with documented facts. I encourage healthy skepticism – question everything, especially when it involves reporting. Here at ACJ, we’ve been keeping an eye on other published information regarding Karlie – as we have done and will continue to do.
Letters: Support Science, #VoteScience | The McGill Daily
Written by: Anh-Khoi Trinh, Stefanie Perrier, Travis Moore, Martha Lee and Olga Koppel | Visual by: Sequoia Kim October 19, 2019 This September, millions of young people worldwide marched at climate strikes protesting government inaction. The message, delivered by Swedish teen climate activist Greta Thunberg, was clear: “Listen to the science”. Young adults dominated the turnout at these marches and acted as a driving force, with their heads held high and voices calling for change.
American Crime Journal |
The true crime genre has grown leaps and bounds over the last several years, and with that comes content from the full spectrum of online creatives. Podcasts, blogs, YouTube videos, Facebook groups and pages, all dedicated to providing the masses with crime stories and opinions for their eager consumption. The underlying issue has been, and continues to be, the unreliability of the content and plagiarism.
American Crime Journal |
Law enforcement’s role in Karlie’s disappearance has become the subject of much scrutiny. A common misconception is that Mono County Sheriff’s Office was insufficient in their response. In reality, Karlie was afforded considerable professional search and rescue resources. MCSO also formed and dispatched a twenty officer “hotshot” team with the objective of raiding homes and/or locations where Karlie could have been kept, either willingly or not.
American Crime Journal |
I found myself invited into the Guse home. Zach standing in the entryway. Up until this point, interpreting the family of the missing girl was, at best, like reading Braille. Braille being podcasts of interviews, browsing FB profiles, reading and rereading comments, watching clips of the family on Dr. Phil and a local news segment on which the Guses appreared. Certainly distant from what it’s like to meet someone in the flesh.
Applications are open for 2020
On July 1, 2015, I launched a crowdfunding campaign to start TechCongress. Over the course of a few weeks, I raised just over $8,000, which helped me pay for an accelerator program, a few months of coworking, and a round trip ticket to New York where I met our first big funder. Since then, we’ve sent 23 technologists to Congress, who’ve served with the most influential members of the House and Senate.
"Solving Nonlinear Heat Transfer Problems Using Variation of Parameters" by Travis J. Moore and Matthew R. Jones
Authors Travis J. Moore, Brigham Young University - ProvoFollow Matthew R. Jones, Brigham Young University - ProvoFollow Keywords Variation of parameters, Nonlinear differential equations, Heat transfer applications Abstract Nonlinear problems arise in many heat transfer applications, and several analytical and numerical methods for solving these problems are described in the literature.
"Analysis of the Conduction-Radiation Problem in Absorbing, Emitting, N" by Travis J. Moore and Matthew R. Jones
Authors Travis J. Moore, Brigham Young University - ProvoFollow Matthew R. Jones, Brigham Young University - ProvoFollow Keywords Conduction-Radiation, Plan parallel, Non-gray, Participating Medium, Exact methods Abstract Systems in which both conduction and radiation are the dominant modes of heat transfer are important in many engineering applications and various numerical methods exist to analyze such systems.
Solving the Tech Deficit on Capitol Hill: A Call for Applications
Anyone who saw Facebook CEO Mark Zuckerberg’s testimony before Congress in April witnessed first-hand what I experienced for six years as a congressional staffer: the Senate and the House of Representatives aren’t up to the task of understanding how technology is reshaping society. Senior Members of Congress didn’t seem to understand how Facebook made money or targeted ads. And some couldn’t distinguish Facebook from an email platform or internet service provider.
Solving the Tech Deficit on Capitol Hill: A Call for Applications
Anyone who saw Facebook CEO Mark Zuckerberg’s testimony before Congress in April witnessed first-hand what I experienced for six years as a congressional staffer: the Senate and the House of Representatives aren’t up to the task of understanding how technology is reshaping society. Senior Members of Congress didn’t seem to understand how Facebook made money or targeted ads. And some couldn’t distinguish Facebook from an email platform or internet service provider.
Bringing technology expertise to Congress, when they need it most
Travis Moore is the founder and director of TechCongress, a nonpartisan initiative incubated at New America that places technology fellows in Congress to increase government knowledge of emerging technology issues and inform policymaking. Knight Foundation announced $1 million in support to TechCongress today, adding to its previous support of the initiative.
Measuring Integrin Conformational Change on the Cell Surface with Super-Resolution Microscopy
Localization of the Head of LFA-1 in Migrating Cells Adherent to ICAM-1 On Fibronectin Substrates, the LFA-1 Headpiece Is Markedly Closer to the Cell Surface LFA-1 Headpiece Position above the Plasma Membrane Is Perturbed by Small-Molecule Allosteric Modulators Determining mEOS3.2 Orientation and Fluorophore Distance from the Membrane in Models of mEOS3.2-LFA-1 Using iPALM, we have measured the distance of the LFA-1 head from the coverslip on adherent Jurkat cells.
Review: Batman #38 By Tom King, Travis Moore & Giulia Brusco
The story begins with Bruce comforting a child named Matthew whose parents have been murdered recently. His father worked for Wayne Enterprises and is now under the care of his butler, Taylor. Meanwhile Batman confronts Victor Zsasz in prison for the murders, but is not met with a lot of cooperation. Batman digs a bit deeper and finds that Zsasz may not be directly involved after all. There are various clues left that point to possible suspects after additional murders occur.
Direction of actin flow dictates integrin LFA-1 orientation during leukocyte migration
EGFP or moxGFP47 were inserted into the ?3-?4 loop of blade 4 of the ?L integrin ?-propeller domain26. Integrin Gly residues adjacent to GFP were mutated to Ala or Gln residues for helix propensity as indicated, linkers were added for flexibility, or GFP residues were deleted for less flexibility as follows.
Opinion: Capitol Hill has a sexual harassment problem
In light of ongoing revelations of sexual harassment across the country, we decided to draft a letter two weeks ago urging Senate and House leaders to take more robust action against harassment on Capitol Hill, where we both worked for years. We thought we could get 100 signatures from fellow former congressional staffers. We began circulating that letter nearly two weeks ago. Within four days, it had been signed by 1,500 former staff.
Capitol Hill has a problem. Sexual harassment training is not enough to solve it.
In light of ongoing revelations of sexual harassment across the country, we decided to draft a letter two weeks ago urging Senate and House leaders to take more robust action against harassment on Capitol Hill, where we both worked for years. We thought we could get 100 signatures from fellow former congressional staffers. We began circulating that letter last Monday. Within four days, it had been signed by 1,500 former staff.
Combs Falls Short to Tempe on the Road - trivalleycentral.com: Local Sports
The tone was set early on the opening kickoff, which resulted in a Buffalo touchdown, giving Tempe high school the lead within the first 15 seconds of the game. Not long after their first score, Tempe was able to strike again by blocking a punt deep in Coyote territory and causing a safety. The Coyotes showed their grittiness by playing throughout most of the remaining half without surrendering a point.
Coyotes still in search of first season win - trivalleycentral.com: Local Sports
The Bears got on the board early by taking the opening kickoff down field and scored off of a 20-yard touchdown pass off the arm of senior QB Gunner Bundrick. After a quick three and out from the Coyotes offense, the Bradshaw Mountain Bears once again got into the end zone through the air, putting them ahead 14-0 before the first quarter had ended.
Spartans begin season with loss to McClintock - trivalleycentral.com: Local Sports
“We let the little things beat us,” Stuart said. “Early on, I thought we should have scored two or three times in the first half.” Vista Grande spent nearly the entire first half in a defensive struggle that kept both teams from putting any points on the board. McClintock struck first with an interception that was returned for a touchdown. A few minutes later, the Chargers forced a fumble on the Spartans’ first play following the touchdown and recovered the ball deep in Vista Grande territory.
STV law enforcement officer running in GOP primary - trivalleycentral.com: News
After spending two years on a church mission and then some time afterward working on his own businesses, Lamb spent a while working on a dairy farm, a job that he appreciates to this day. “That’s really where I learned what hard work was,” said Lamb.
Maricopa Democrat making second run for the office - trivalleycentral.com: News
Taylor, a Maricopa resident who won the Democratic nomination for the same position back in 2012 but eventually lost to Republican incumbent Paul Babeu, has high hopes for what he could accomplish if elected. At the front of his desired actions, he said, is changing the perception that the citizens of Pinal County currently have of the Sheriff’s Office. “There is no accountability between the prosecutor and the sheriff’s department,” Taylor said. “The people need to be treated with respect.
Eloy Dem making run for Senate - Maricopa Monitor: Entertainment
Atchue — whose resume is decorated with military experience, a teaching background and a 33-year stint with the U.S. Postal Service — said that the original discussion of him running for the state Senate seat in Legislative District 11 wasn’t something that he took seriously. In his mind, it was something he could easily dismiss. His Democratic colleagues, however, wanted to make him realize that they weren’t kidding around. “It was flattering, at first,” said Atchue.
‘Mello Yellow’ drags come to Wild Horse Pass - trivalleycentral.com: Arizona News
The event will take place over a span of three days, with the first two consisting of drivers participating in qualifying rounds and the finals taking place on Sunday. The featured categories for the races include pro stock, pro stock motorcycle, top fuel and funny car. General admission and reserved tickets are readily available at the event website. Each ticket will also double as a pit pass for the event.
Election 2016: Eloy Dem making run for Senate - trivalleycentral.com: Area News
“It was flattering, at first,” said Atchue. “My friends that I had done work with, though, quickly made me realize that they were being serious.” Now fully committed, Atchue has begun his trek toward securing a seat in Arizona’s Legislature. As a Democratic leader, Atchue is waging a campaign focused on a different set of ideals from the GOP-dominated current Legislature. One of his primary focuses is on the current tax structure.
Candidate for Arizona House seat aiming to break mold - Maricopa Monitor: Around Arizona
Hammond, who has a master’s degree in inorganic chemistry from the University of Arizona and is now a Ph.D. candidate there, said she started digging into local politics in recent years because of the issues she had begun to familiarize herself with due to her studies. One of her primary motivations for running is concern about how toxic chemicals produced through mining affect surrounding agricultural operations and the environment.
Election 2016 - LD11 race: Candidate for House wants to break mold - trivalleycentral.com: Arizona News
MARANA — A civil rights advocate, an environmentalist and an education enthusiast. These are the types of descriptions that Marana resident Corin Hammond wants to be known for as she runs for a Legislative District 11 seat in the Arizona House of Representatives. Since moving to southern Arizona from Louisiana in 2007, Hammond has been enamored with the state and all that it has to offer. “I absolutely love living here,” Hammond said.
At the Capitol: Students mixed about legislation to allow guns on campuses - trivalleycentral.com: Arizona News
Borrelli has stated current policies adopted by Arizona’s universities and colleges have failed to protect the students. He believes that they restrict students and faculty from being able to defend themselves from those who disregard the law. The Arizona Board of Regents has unanimously voted to oppose the bill, along with its counterpart HB 2338, which would allow concealed weapons to be carried on the roads at educational institutions as well.
So is former deputy Lamb - trivalleycentral.com: Florence Perspective
After spending two years on his church mission and then some time afterward working on his own businesses, Lamb spent a while working on a dairy farm, a job that he is still to this day most appreciative of. “That’s really where I learned what hard work was,” said Lamb.
ELECTION 2016: Taylor running for sheriff - trivalleycentral.com: News
Taylor, who won the Democratic nomination for the same position back in 2012 but eventually lost to incumbent Paul Babeu, has high hopes for what he can accomplish if elected. At the front of his desired actions is changing the perception that the citizens of Pinal County currently have of the sheriff’s department. “There is no accountability between the prosecutor and the sheriff’s department,” Taylor said. “The people need to be treated with respect.
Election 2016: Maricopa Dem back for a 2nd campaign - trivalleycentral.com: Arizona News
Taylor, a Maricopa resident who won the Democratic nomination for the same position back in 2012 but eventually lost to Republican incumbent Paul Babeu, has high hopes for what he could accomplish if elected. At the front of his desired actions, he said, is changing the perception that the citizens of Pinal County currently have of the Sheriff’s Office. “There is no accountability between the prosecutor and the sheriff’s department,” Taylor said. “The people need to be treated with respect.
Ex-CG deacon receives 5 years probation - trivalleycentral.com: Area News
He was accused of inappropriately touching the breasts of two women and of trying to kiss and hug them. One instance allegedly occurred prior to a funeral service and the other after a church service. Under church policy, Tarango was automatically suspended from his church duties after the first allegation was made. An investigation took place shortly after the second incident occurred in 2013.
Former PCSO deputy seeks department’s top job - Maricopa Monitor: Around Pinal
After spending two years on his church mission and then some time afterward working on his own businesses, Lamb spent a while working on a dairy farm, a job that he is still to this day most appreciative of. “That’s really where I learned what hard work was,” said Lamb.
Babeu talks guns with Obama at CNN Town Hall - Maricopa Monitor: Around Pinal
The Republican sheriff, who is running for Congress in Arizona’s 1st District, got into a spirited exchange with the president on gun control in a CNN town hall Thursday night. Babeu questioned Obama’s executive action plans, stating that the president himself had said that his actions wouldn’t have prevented any of the mass shootings that had occurred in recent years. Before responding, the president paused and wished Babeu “good luck” in his congressional race.
Lamb says job at dairy helped him in police work - trivalleycentral.com: Area News
After spending two years on a church mission and then some time afterward working on his own businesses, Lamb spent a while working on a dairy farm, a job that he appreciates to this day. “That’s really where I learned what hard work was,” said Lamb.
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