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ArticleOnline nowOpen access Affiliations & Notes 1Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, 02215, United States of America 2Department of Genetics, Blavatnik Institute, Harvard Medical School, Boston, MA, 02115, United States of America 3Department of Cancer Immunology and Virology, Dana-Farber Cancer Institute, Boston, MA, 02215, United States of America 4Department of Immunology, Harvard Medical School, Boston, MA, 02115, United States of America 5Systems,...
Abstract During flight, pilots are exposed to unique environmental factors such as low air pressure, acceleration, and psychological stress, which can lead to altered glucose metabolism that poses a threat to flight safety. Traditional fingerstick blood glucose monitoring has drawbacks such as the need for intermittent readings, time-consuming procedures, and passive monitoring.
Abstract Precise control of protein function in living cells is essential for engineering programmable biological systems and therapeutic applications. However, most current strategies act indirectly by altering protein stability, localization, or proximity rather than directly modulating binding activity. Here we present VIPbodies, nanobodies engineered with self-cleaving viral proteases that convert protease inhibition into drug-dependent antigen recognition.
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