Triantafyllos Stylianopoulos

Abstract INTRODUCTION RESULTS DISCUSSION MATERIALS AND METHODS Acknowledgments Supplementary Materials REFERENCES Information & Authors Metrics & Citations View Options References Figures Tables Media Share Abstract Cells sense and respond to diverse physical cues as they migrate toward distant sites. While much is known about the roles of cellular molecules in the regulation of mechanosensitivity, our understanding of how extracellular cues influence this property remains limited.

Abstract Glioblastoma multiforme (GBM) remains a devastating disease with a poor prognosis. GBM progression generates mechanical forces that compromise blood vessels’ functionality, impair perfusion, and create hypoxic regions, which in turn reduce radiosensitivity. While the link between hypoxia and radiosensitivity is known, a quantitative methodology to predict this effect is lacking.

Loading metrics Open Access Peer-reviewed Research Article ? This is an uncorrected proof. Citation: Koutsi M, Stylianopoulos T, Mpekris F (2025) Optimizing therapeutic outcomes with Mechanotherapy and Ultrasound Sonopermeation in solid tumors. PLoS Comput Biol 21(9): e1012676. https://doi.org/10.1371/journal.pcbi.1012676 Editor: Juan Soler, Universidad de Granada, SPAIN Received: November 27, 2024; Accepted: September 17, 2025; Published: September 23, 2025 Copyright: © 2025 Koutsi et al.