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Articles by Usha Menon
The double-edged sword of ovarian cancer information for women at increased risk who have previously taken part in screening
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Chandigarh at 73: How a City Outgrew Its Utopia
In the early 1950s, a wide, sloping plain at the foot of the Shivalik Hills in northwest India was cleared of over 50 agrarian villages. From that newly blank slate rose Chandigarh, a city conceived not merely as a regional capital for a post-Partition Punjab, but as a bold statement of identity for a newly independent nation.
Differences in overall survival for invasive epithelial ovarian cancer by race and ethnicity: results from the Ovarian Cancer Association Consortium
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Abstract Prior studies have examined survival in patients with epithelial ovarian cancer (EOC); however, few consider race and ethnicity, particularly disaggregating Asian and Native Hawaiian/Pacific Islander women. We analysed data from 18 Ovarian Cancer Association Consortium studies, including women with EOC from Asian (n = 697), non-Hispanic Black (n = 267), Hispanic (n = 492), Native Hawaiian/Pacific Islander (n = 98) and non-Hispanic White (n = 12,998) racial and ethnic groups.
By Nicola S. Meagher, Kami K. White, Lynne R Wilkens, Hoda Anton-Culver, Elisa V Bandera, Michael Carney, Daniel Cramer, Kara L. Cushing-Haugen, Anna deFazio, Jennifer Doherty-Bigara, Aleksandra Gentry-Maharaj, Ellen L. Goode, Marc Goodman, Holly Harris, Beth Karlan, Scott Kaufmann, Martin Köbel, Loic Le Marchand, Jenny Lester, Valerie McGuire, Usha Menon, Francesmary Modugno, Kirsten B Moysich, Celeste Leigh Pearce, Paul Pharoah, Malcolm C. Pike, Bo Qin, Harvey A. Risch, Joseph H. Rothstein, Danja Sarink, Weiva Sieh, Helen HarperLes Steed, Kathryn L. Terry, Pamela Thompson, Linda Titus, Toon Van Gorp, Alice S Whittemore, Stacey J. Winham, Susan Jordan, Anna Wu, Penelope M Webb, Lauren C. Peres, Melissa A Merritt, Linda E. Kelemen, Jennifer M. Koziak
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Nature
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Can ovarian cancer screening work? A secondary analysis of the UK collaborative trial of ovarian cancer screening
Abstract The UK Collaborative Trial of Ovarian Cancer Screening (UKCTOCS; 2001–2020) showed no reduction in disease mortality in its primary intervention arm using multimodal screening (MMS) with longitudinal Cancer Antigen 125 (CA125) and transvaginal ultrasound. Whether this null result reflects the stop-screen design, screening performance, or ovarian cancer natural history remains unclear.
Whole exome sequencing and 12-SNP LDL polygenic score in South Indian patients with familial hypercholesterolemia - Scientific Reports
Abstract Heterozygous familial hypercholesterolemia (FH), a monogenic cause for premature coronary artery disease (CAD) is often underdiagnosed. In individuals who meet the FH diagnostic criteria and lack pathogenic variants, polygenic factors are recognized as potential contributors. This study aimed to characterize the spectrum of genetic variants and determine the low-density lipoprotein polygenic risk score (LDL-PRS) among clinically diagnosed FH participants from South India.
Rural Florida needs better cancer care. Here’s how we can do it
Cancer impacts people of all ages, genders and backgrounds, yet access to care differs dramatically based on location. In rural Florida, many residents encounter significant obstacles in obtaining timely, high-quality preventive and curative cancer treatment. Geographic isolation and inadequate health care infrastructure, among other challenges, frequently lead to delayed diagnoses, limited treatment options and poorer survival outcomes. Usha Menon [ USF Health ] Nicholas J.
Ovarian tumor cells gain competitive advantage by actively reducing the cellular fitness of microenvironment cells - Nature Biotechnology
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Abstract Cell competition and fitness comparison between cancer and tumor microenvironment (TME) cells determine oncogenic fate. Our previous study established a role for human Flower isoforms as fitness fingerprints, where the expression of Flower Win isoforms in tumor cells leads to growth advantage over TME cells expressing Lose isoforms.
By Esha Madan, Jochen Wilhelm, Patrick Martin Verified, Anna Gustafsson, Narsimha Mamidi, Lin Lin, Lena Neufeld, Hyobin Kim, Isabel Correia, Emad A Rakha, Steven Grossman, Gary Robinson, Sagar Rayamajhi, Manny D. Bacolod, Hope Richards, Ronit Satchi-Fainaro, Kenneth P Nephew, Seungpyo Hong, George M Church, Usha Menon, Andrew Godwin, Yonglun Luo, Alexandar Tzankov, Kirsten D. Mertz, Danny Jonigk, David Sidransky, Eduardo Moreno, Isabelle Dreier, Davide Accardi, Amalie Lykke Olsen, Frits Alan Thorsen
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Nature
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Can B Corps save the world?
THE “shareholder primacy” doctrine that promoted profit maximisation as the purpose of business is fading. The increasing wealth gap, widening social inequality and environmental degradation are a blemish on our report card. We stand at the crossroads of this identity crisis, which offers extraordinary opportunities. Businesses are now called to create value for employees, customers, communities, suppliers and investors – focusing on purpose over profit.
Screening and prevention of ovarian cancer
Med J Aust || doi: 10.5694/mja2.52227 Published online: 26 February 2024 Around 314 000 women worldwide are diagnosed with ovarian cancer annually and 207 000 women die of it.1 GLOBOCAN, the World Health Organization Global Cancer Observatory, predicts the number of ovarian cancer cases and deaths will rise globally by 36% and 47% respectively over 20 years.2 Correspondingly, the predicted increase in ovarian cancer cases and deaths in Australia is 42% and 55% respectively by 2040.
Serum biomarker-based early detection of pancreatic ductal adenocarcinomas with ensemble learning - Communications Medicine
Abstract Background Earlier detection of pancreatic ductal adenocarcinoma (PDAC) is key to improving patient outcomes, as it is mostly detected at advanced stages which are associated with poor survival. Developing non-invasive blood tests for early detection would be an important breakthrough.
Increased FOXJ1 protein expression is associated with improved overall survival in high-grade serous ovarian carcinoma: an Ovarian Tumor Tissue Analysis Consortium Study | British Journal of Cancer
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Abstract Background Recently, we showed a >60% difference in 5-year survival for patients with tubo-ovarian high-grade serous carcinoma (HGSC) when stratified by a 101-gene mRNA expression prognostic signature. Given the varied patient outcomes, this study aimed to translate prognostic mRNA markers into protein expression assays by immunohistochemistry and validate their survival association in HGSC.
By Martin Widschwendter, James Brenton, Julie Cunningham, Alexander Ochoa Hein, Anna Jakubowska, Catherine Kennedy, Ana Osorio, Robert A. Vierkant, Stacey J. Winham, Anna deFazio, AOCS Group, Jennifer Doherty-Bigara, Maria Garcia, Maria García Verified, María García Gil, Beth Karlan, Hans-Peter Sinn, Caroline Ford, Usha Menon, Nicola S. Meagher, Prafull Ghatage, Marjorie J. Riggan, David D. Bowtell
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Nature
Verified
Implementation of a Continuing Education Program for Frontline Nurses During the COVID-19 Pandemic
Original Article Abstract A continuing education program was designed to help nurses stay safe while providing nursing care to patients during the COVID-19 pandemic. The program addressed topics aimed at empowering nurses to advocate for their own health and safety as a result of increased knowledge related to caring for patients and communities during a global pandemic. A four-part, on-demand webinar series was offered from January 2021 through January 2022.
Diagnostic routes and time intervals for ovarian cancer in nine international jurisdictions; findings from the International Cancer Benchmarking Partnership (ICBP) | British Journal of Cancer
Abstract Background International Cancer Benchmarking Partnership Module 4 reports the first international comparison of ovarian cancer (OC) diagnosis routes and intervals (symptom onset to treatment start), which may inform previously reported variations in survival and stage.
Ovarian cancer population screening and mortality after long-term follow-up in the UK Collaborative Trial of Ovarian Cancer Screening (UKCTOCS): a randomised controlled trial
Summary Background Ovarian cancer continues to have a poor prognosis with the majority of women diagnosed with advanced disease. Therefore, we undertook the UK Collaborative Trial of Ovarian Cancer Screening (UKCTOCS) to determine if population screening can reduce deaths due to the disease. We report on ovarian cancer mortality after long-term follow-up in UKCTOCS.
Instilling logic in teaching mathematics
more-in Current methods in schools hurt children’s thinking The two children were absorbed in making pictures using colourful geometrical pieces. Anisha made a big elephant and Aman a big flowerpot. They finished and counted 28 pieces in both. They seemed happy with their work. “What if you have to make the picture bigger and have 50 pieces in it? Then how many more pieces would you need?” Both children understood the question.
A Study to Assess the Impact of 15 to 30 Minutes daily Counselling, Affirmation and Meditation on the Fresher B.Sc. Nursing students for 15 Days
ABSTRACT: The present day stressful and pressurized atmosphere, makes the fresher Nursing students easily breakdown and lose their faith and trust in themselves Therefore, a study was conducted for 15 to 30 minutes daily counseling, affirmation and meditation on the fresher B.Sc. Nursing students for 15 days. A total of 38 B.Sc. Nursing students participated for this study. It had a positive impact on them. It enhanced the level of concentration and attention in their performance.
Risk reducing early salpingectomy and delayed oophorectomy as a two staged alternative for primary prevention of ovarian cancer in increased risk women: a commentary - Gaba - - BJOG: An International Journal of Obstetrics & Gynaecology - Wiley Online
Commentary Risk reducing early salpingectomy and delayed oophorectomy as a two staged alternative for primary prevention of ovarian cancer in increased risk women: a commentary Faiza Gaba Barts Cancer Institute, Queen Mary University of London, Old Anatomy Building, Charterhouse Square, London, EC1M 6BQ UK Department of Gynaecological Oncology, St Bartholomew's Hospital, London, UK, EC1A 7BE Search for more papers by this author Ranjit Manchanda Corresponding Author E-mail address:...
Steps towards effective gynaecological cancer screening
Wang, Y. et al. Evaluation of liquid from the papanicolaou test and other liquid biopsies for the detection of endometrial and ovarian cancers. Sci. Transl. Med. 10, eaap8793 (2018). Kinde, I. et al. Evaluation of DNA from the papanicolaou test to detect ovarian and endometrial cancers. Sci. Transl. Med. 5, 167ra4 (2013). Jacobs, I. et al. Sensitivity of transvaginal ultrasound screening for endometrial cancer in postmenopausal women: a case-control study within the UKCTOCS cohort. Lancet Oncol. 12, 38–48 (2011).
The cost-effectiveness of screening for ovarian cancer: results from the UK Collaborative Trial of Ovarian Cancer Screening (UKCTOCS)
Analysis suggests that, after accounting for the lead time required to establish full mortality benefits, a national OCS programme based on the MMS strategy quickly approaches the current NICE thresholds for cost-effectiveness when extrapolated out to lifetime as compared with the within-trial ICER estimates. Whether MMS could be recommended on economic grounds would depend on the confirmation and size of the mortality benefit at the end of an ongoing follow-up of the UKCTOCS cohort.
Changing the Risk Threshold for Surgical Prevention of Ovarian Cancer
Ovarian cancer (OC) remains a lethal disease and a major cause of deaths from gynaecological cancer particularly in western countries. Despite advances in treatment, there have been only marginal improvements in survival rates over the last 30years.
The ABCD of an Asian philanthropist’s journey - 101fundraising
Based on what I see as the evolution of giving habits within the high-net worth families in Asia, here are the four categories of philanthropists I have worked with: Usually the patriarch of the business family, who has seen poverty and life struggles during his early days, either as a migrant or during the struggles against colonial rulers. His philosophy on giving is based mainly on altruistic motives- of giving back.
A Breast Cancer Fear Scale: Psychometric Development
Fear of breast cancer has been inversely associated with participation in screening. However, investigators have generally used only one item or global scales to measure fear. This report describes development of a fear scale specific to breast cancer. Data from a large study involving mammography adherence were used to test the breast cancer fear scale for validity and reliability. Construct validity was verified through factor analysis and regression analysis predicting mammography.
Ovarian cancer screening: UKCTOCS trial - Authors' reply
We are grateful for the positive comments about the conduct of UKCTOCS.1x1Jacobs, IJ, Menon, U, Ryan, A et al. Ovarian cancer screening and mortality in the UK Collaborative Trial of Ovarian Cancer Screening (UKCTOCS): a randomised controlled trial. Lancet. ; 387: 945–956 Summary | Full Text | Full Text PDF | PubMedSee all References1 The total cost was roughly £27 million for 2·19 million woman-years of screening or follow-up, which is a remarkably low cost of about £12·30 per woman-year.
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